Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies

Autor: Fátima Duarte Freire, Túlio Flávio Accioly de Lima e Moura, Fernanda Nervo Raffin, Cícero Flávio Soares Aragão, Janaina da Silva Goes

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019)
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18015
Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18015
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca90ed2b10d80d1cf525bfb7641afca4
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100603&tlng=en

Calcium ion-dependent increase in thermostability of dextran glucosidase from Streptococcus mutans

Autor: Kobayashi, Momoko, Hondoh, Hironori, Mori, Haruhide, Saburi, Wataru, Okuyama, Masayuki, Kimura, Atsuo

Publikováno v: Bioscience, biotechnology, and biochemistry. 75(8):1557-1563

Dextran glucosidase from Streptococcus mutans (SmDG), which belongs to glycoside hydrolase family 13 (GH13), hydrolyzes the non-reducing terminal glucosidic linkage of isomaltooligosaccharides and dextran. Thermal deactivation of SmDG did not follow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::fe226ffe008df55e50049e18685a93d1
http://hdl.handle.net/2115/48146