Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with Covid-19. A randomized clinical trial

Autor: Lawler, P.R., Derde, L.P.G., Veerdonk, F.L. van de, McVerry, B.J., Huang, D.T., Berry, L.R., Lorenzi, E., Kimmenade, R.R.J. van, Gommans, F., Vaduganathan, M., Leaf, D.E., Baron, R.M., Kim, E.Y., Frankfurter, C., Epelman, S., Kwan, Y., Grieve, R., O'Neill, S., Sadique, Z., Puskarich, M., Marshall, J.C., Higgins, A.M., Mouncey, P.R., Rowan, K.M., Al-Beidh, F., Annane, D., Arabi, Y.M., Au, C., Beane, A., Bentum-Puijk, W. van, Bonten, M.J.M., Bradbury, C.A., Brunkhorst, F.M., Burrell, A., Buzgau, A., Buxton, M., Cecconi, M., Cheng, A.C., Cove, M., Detry, M.A., Estcourt, L.J., Ezekowitz, J., Fitzgerald, M., Gattas, D., Godoy, L.C., Goossens, H., Haniffa, R., Harrison, D.A., Hills, T., Horvat, C.M., Ichihara, N., Lamontagne, F., Linstrum, K.M., McAuley, D.F., McGlothlin, A., McGuinness, S.P., McQuilten, Z., Murthy, S., Nichol, A.D., Owen, D.R.J., Parke, R.L., Parker, J.C., Pollock, K.M., Reyes, L.F., Saito, H., Santos, M.S., Saunders, C.T., Seymour, C.W., Shankar-Hari, M., Singh, V., Turgeon, A.F., Turner, A.M., Zarychanski, R., Green, C., Lewis, R.J., Angus, D.C., Berry, S., Gordon, A.C., McArthur, C.J., Webb, S.A.

Publikováno v: Lawler, P R, Derde, L P G, Van De Veerdonk, F L, McVerry, B J, Huang, D T, Berry, L R, Lorenzi, E, Van Kimmenade, R, Gommans, F, Vaduganathan, M, Leaf, D E, Baron, R M, Kim, E Y, Frankfurter, C, Epelmaņ, S, Kwan, Y, Grieve, R, O'Neill, S, Sadique, Z, Puskarich, M, Marshall, J C, Higgins, A M, Mouncey, P R, Rowan, K M, Al-Beidh, F, Annane, D, Arabi, Y M, Au, C, Beane, A, Van Bentum-Puijk, W, Bonten, M J M, Bradbury, C A, Brunkhorst, F M, Burrell, A, Buzgau, A, Buxton, M, Cecconi, M, Cheng, A C, Cove, M, Detry, M A, Estcourt, L J, Ezekowitz, J, Fitzgerald, M, Gattas, D, Godoy, L C, Goossens, H, Haniffa, R, Harrison, D A, Hills, T, Horvat, C M, Ichihara, N, Lamontagne, F, Linstrum, K M, McAuley, D F, McGlothlin, A, McGuinness, S P, McQuilten, Z, Murthy, S, Nichol, A D, Owen, D R J, Parke, R L, Parker, J C, Pollock, K M, Reyes, L F, Saito, H, Santos, M S, Saunders, C T, Seymour, C W, Shankar-Hari, M, Singh, V, Turgeon, A F, Turner, A M, Zarychanski, R, Green, C, Lewis, R J, Angus, D C, Berry, S, Gordon, A C, McArthur, C J & Webb, S A 2023, ' Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with Covid-19. A randomized clinical trial ', JAMA, vol. 329, no. 14, pp. 1183-1196 . https://doi.org/10.1001/jama.2023.4480
Jama : Journal of the American Medical Association, 329, 14, pp. 1183-1196
Jama : Journal of the American Medical Association, 329, 1183-1196

Contains fulltext : 291878.pdf (Publisher’s version ) (Closed access) IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE: To determine whether angiotensin-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8ff6a211c4c42dc02259195c83981b0d
https://pure.qub.ac.uk/en/publications/8cae3556-8039-49ea-a414-6da1b5a01052

Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis

Autor: Barbara Tomic, Tomislav Smoljo, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Drago Batinic, Antonio Bedalov, Dora Visnjic

Acute myeloid leukemia (AML) is characterized by arrested differentiation making differentiation therapy a promising treatment strategy. Recent success of inhibitors of mutated isocitrate dehydrogenase (IDH) invigorated interest in differentiation th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d328b03c9280a3fbd95f7362c438e671
https://www.bib.irb.hr/1211738

A versatile stereocontrolled synthesis of 2-deoxyiminosugar C -glycosides and their evaluation as glycosidase inhibitors

Autor: Erwan Le Grognec, Carmen Ortiz Mellet, Alexandre Lumbroso, M. Isabel García-Moreno, Clément Berthonneau, Aurélien Planchat, Isabelle Beaudet, Jean-Paul Quintard

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (5), pp.1083-1099. ⟨10.1039/d0ob02249g⟩

International audience; A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved through Sn/Li transmetalation of the corresponding stannylated dehydropiperidines or of their precursors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f7d08bfb233a3d16e4bf48692fb1e3
https://hal.archives-ouvertes.fr/hal-03388809/document

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?

Autor: Maria C. Cid, Sander Willox, Elizabeth A. V. Jones, Giusy Di Conza, Donatella Ponti, Rosa Martín-Pérez, Roser Alba-Rovira, Ward Celus, Massimiliano Mazzone, Manuel Ehling

Publikováno v: Circ Res
Circulation Research, 127(6), 707-723. LIPPINCOTT WILLIAMS & WILKINS

Rationale: How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. Yet, mechanisms underlying vascular remodeling remain poorly established. A better understanding of these processes may lead to the desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5049a857d8a7f409e8a1cea5ba5528
https://pubmed.ncbi.nlm.nih.gov/32853096

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

Autor: Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Junichi Matsumoto, Fuyuko Takata, Takashi Machida, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi

Publikováno v: Brain Research. 1692:34-44

Interleukin (IL)-6 is an important mediator of neurovascular dysfunction, neurodegeneration and/or neuroinflammation. We previously reported that brain pericytes released higher levels of IL-6 than did glial cells (astrocytes and microglia) in respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0
https://doi.org/10.1016/j.brainres.2018.04.023