Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Enzo R, Porrello"'
Autor:
Natalie Charitakis, Agus Salim, Adam T. Piers, Kevin I. Watt, Enzo R. Porrello, David A. Elliott, Mirana Ramialison
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Identifying spatially variable genes (SVGs) is a key step in the analysis of spatially resolved transcriptomics data. SVGs provide biological insights by defining transcriptomic differences within tissues, which was previously unachievable u
Externí odkaz:
https://doaj.org/article/1b4f8dd834724091bdaa2bce84d5993b
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102371- (2023)
Summary: Here, we provide a protocol for next-generation human cardiac organoid modeling containing markers of vascularized tissues. We describe steps for cardiac differentiation, harvesting cardiac cells, and generating vascularized human cardiac or
Externí odkaz:
https://doaj.org/article/e8c0ba7c0883453db3662cafe27bb846
Autor:
Shicheng Sun, Jacky Y. Li, Hieu T. Nim, Adam Piers, Mirana Ramialison, Enzo R. Porrello, Igor E. Konstantinov, Andrew G. Elefanty, Edouard G. Stanley
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which bears little si
Externí odkaz:
https://doaj.org/article/78af4cce953b45bf916d16eb982f3b10
Autor:
Timothy N. McOwan, Lauren A. Craig, Anne Tripdayonis, Kathy Karavendzas, Michael M. Cheung, Enzo R. Porrello, Rachel Conyers, David A. Elliott
Publikováno v:
Cardio-Oncology, Vol 6, Iss 1, Pp 1-6 (2020)
Abstract Background Anthracyclines are a mainstay of chemotherapy. However, a relatively frequent adverse outcome of anthracycline treatment is cardiomyopathy. Multiple genetic studies have begun to dissect the complex genetics underlying cardiac sen
Externí odkaz:
https://doaj.org/article/00a1c81a173c4ade91cf57973bb5ce84
Autor:
Megan J. Bywater, Deborah L. Burkhart, Jasmin Straube, Arianna Sabò, Vera Pendino, James E. Hudson, Gregory A. Quaife-Ryan, Enzo R. Porrello, James Rae, Robert G. Parton, Theresia R. Kress, Bruno Amati, Trevor D. Littlewood, Gerard I. Evan, Catherine H. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and prolife
Externí odkaz:
https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d895
Autor:
Aowen Zhuang, Anna C. Calkin, Shannen Lau, Helen Kiriazis, Daniel G. Donner, Yingying Liu, Simon T. Bond, Sarah C. Moody, Eleanor A.M. Gould, Timothy D. Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, Julie R. McMullen, Brian G. Drew
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102537- (2021)
Summary: Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (1700020I14
Externí odkaz:
https://doaj.org/article/453eb2947cf84c34a110e74e3feab67a
Autor:
James W. McNamara, Benjamin L. Parker, Holly K. Voges, Neda R. Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D. Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia T. L. Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L. Pointer, Petros Syrris, Luis R. Lopes, Perry M. Elliott, Gordon S. Lynch, Richard J. Mills, James E. Hudson, Kevin I. Watt, Enzo R. Porrello, David A. Elliott
Publikováno v:
Nature Cardiovascular Research. 2:159-173
Muscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of muscle function, the identification of regulatory kinases is important for understanding sarcomere biology. Pathogenic variants in
Autor:
David J. Anderson, David I. Kaplan, Katrina M. Bell, Katerina Koutsis, John M. Haynes, Richard J. Mills, Dean G. Phelan, Elizabeth L. Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S. Ng, Richard P. Davis, Simona Casini, Robert Passier, James E. Hudson, Enzo R. Porrello, Mauro W. Costa, Arash Rafii, Clare L. Curl, Lea M. Delbridge, Richard P. Harvey, Alicia Oshlack, Michael M. Cheung, Christine L. Mummery, Stephen Petrou, Andrew G. Elefanty, Edouard G. Stanley, David A. Elliott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
A gene regulatory network, including the transcription factor Nkx2-5, regulates cardiac development. Here, the authors show that on deletion of NKX2-5 from human embryonic stem cells, there is impaired cardiomyogenesis and changes in action potential
Externí odkaz:
https://doaj.org/article/0896462d0f5d479da41ae7191f638c59
Autor:
Louis T. Dang, Markus Tondl, Man Ho H. Chiu, Jerico Revote, Benedict Paten, Vincent Tano, Alex Tokolyi, Florence Besse, Greg Quaife-Ryan, Helen Cumming, Mark J. Drvodelic, Michael P. Eichenlaub, Jeannette C. Hallab, Julian S. Stolper, Fernando J. Rossello, Marie A. Bogoyevitch, David A. Jans, Hieu T. Nim, Enzo R. Porrello, James E. Hudson, Mirana Ramialison
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background A strong focus of the post-genomic era is mining of the non-coding regulatory genome in order to unravel the function of regulatory elements that coordinate gene expression (Nat 489:57–74, 2012; Nat 507:462–70, 2014; Nat 507:4
Externí odkaz:
https://doaj.org/article/0f1f44ab434441b7b91c6e11217543db
Autor:
Denis Bienroth, Natalie Charitakis, Sabrina Jaeger-Honz, Dimitar Garkov, David A. Elliott, Enzo R. Porrello, Karsten Klein, Hieu T. Nim, Falk Schreiber, Mirana Ramialison
Spatially resolved transcriptomics (SRT) technologies produce complex, multi-dimensional data sets of gene expression information that can be obtained at subcellular spatial resolution. While several computational tools are available to process and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d40caddc5177bf9ba6569640c67de42
https://doi.org/10.1101/2023.03.31.535025
https://doi.org/10.1101/2023.03.31.535025