Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Enzo Paoletti"'
Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization
Autor:
Adrian V. S. Hill, Sarah C. Gilbert, Steve Harris, G. Frankel, Catherine E. M. Allsopp, Enzo Paoletti, Catarina E. Hioe, Robert E. Sinden, Douglas F. Nixon, Guy T. Layton, Magdalena Plebanski, Gordon Dougan
Publikováno v:
Scopus-Elsevier
A variety of vaccine delivery systems including peptides with various adjuvants, recombinant particles, live recombinant viruses and bacteria and plasmid DNA were tested for their ability to induce CD8+ cytotoxic T lymphocytes (CTL) against a well-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf765fcd4c8b2db3192965b67b0bbab7
https://ora.ox.ac.uk/objects/uuid:9a04b05f-412e-416f-8326-9886f36f90a7
https://ora.ox.ac.uk/objects/uuid:9a04b05f-412e-416f-8326-9886f36f90a7
Publikováno v:
Journal of Interferon & Cytokine Research. 18:721-729
Vaccinia virus (VV) has been shown to be relatively resistant to the antiviral effects of interferon-alpha (IFN-alpha) and to rescue replication of IFN-sensitive viruses, such as encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV),
Autor:
John R. Mascola, Mary Clare Walker, Barney S. Graham, Kent J. Weinhold, Mary Lou Clements-Mann, Susan A. Jackson, Robert B. Belshe, Don Stablein, David A. Schwartz, Susan Zolla-Pazner, Robert F. Siliciano, Jean-Louis Excler, Enzo Paoletti, M. Juliana McElrath, Peter F. Wright, James Tartaglia, Serena Xu, Thomas J. Matthews, Faruk Sinangil, Raphael Dolin, R H Hsieh, Patricia E. Fast, Jiri Mestecky, Lawrence Corey, Michael C. Keefer, Geoffrey J. Gorse, Anne Marie Duliege
Publikováno v:
The Journal of Infectious Diseases. 177:1230-1246
A safety and immunogenicity trial was conducted in vaccinia-immune and vaccinia-naive human immunodeficiency virus (HIV)-uninfected adults who were randomized to receive 10(6) or 10(7) TCID50 of canarypox (ALVAC) vector expressing HIV-1MN gp160 or 10
Autor:
Jim Tartaglia, Guido Ferrari, Kent J. Weinhold, C. Berend, D. Moody, W.I. Cox, John Bartlett, J. F. Toso, Janet Ottinger, R. Dodge, Enzo Paoletti
Publikováno v:
Scopus-Elsevier
In the attempt to develop immunotherapeutic strategies for acquired immunodeficiency syndrome capable of activating effector cells in an antigen-specific manner while maintaining the broadest possible T-cell repertoire, we evaluated two canarypox (AL
Autor:
Enzo Paoletti, Yves Rivière, Florence Buseyne, Marie Paule Kieny, Gilles Pialoux, Michael N. Robertson, Béatrice Fleury, James Tartaglia, Geneviève Janvier, Jean Louis Excler
Publikováno v:
Journal of Infectious Diseases. 174:734-738
A vaccine against human immunodeficiency virus (HIV) should induce virus-specific cytotoxic T lymphocyte (CTL) activity. Immunization of uninfected volunteers with a canarypox virus express ing HIV envelope was carried out in a phase I trial. Two i
Autor:
G. S. N. Hui, Lisa A. Ware, C. De Taisne, David C. Kaslow, David E. Lanar, W. R. Ballou, Stephen L. Hoffman, E. B. Kauffman, John A. Tine, Jerald C. Sadoff, Bruce T. Wellde, Robert A. Wirtz, S. P. Chang, D. M. Smith, Enzo Paoletti, K. P. Guito, P. Church, P. Schultheiss, Michael R. Hollingdale
Publikováno v:
Infection and Immunity. 64:3833-3844
The highly attenuated NYVAC vaccinia virus strain has been utilized to develop a multiantigen, multistage vaccine candidate for malaria, a disease that remains a serious global health problem and for which no highly effective vaccine exists. Genes en
Autor:
Enzo Paoletti, Maria Myagkikh, Marjorie Robert-Guroff, Shabnam Alipanah, Genoveffa Franchini, Phillip D. Markham, Robert C. Gallo, James Tartaglia
Publikováno v:
AIDS Research and Human Retroviruses. 12:985-992
Vaccine protocols involving multiple immunizations with molecularly attenuated vaccinia virus (NYVAC) or naturally attenuated canarypox virus (ALVAC) HIV-2 recombinants and subunit boosts have conferred longlasting protection against HIV-2 infection
Publikováno v:
Europe PubMed Central
The p53 protein is an attractive target for immunotherapy, because mutations in the p53 gene are the most common genetic alterations found in human tumors. These mutations result in high levels of p53 protein in the tumor cell, whereas the expression
Autor:
M C Seguin, E. B. Kauffman, W.I. Cox, C. De Taisne, Daniel M. Gordon, Jerald C. Sadoff, Enzo Paoletti, John A. Tine, J P Winslow, Lisa A. Ware, W. R. Ballou, David E. Lanar
Publikováno v:
Infection and Immunity. 64:1666-1671
NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (6
Autor:
Bernard Meignier, Jill Taylor, E.K. Kauffman, Stanley A. Plotkin, James Tartaglia, Enzo Paoletti, Louis Fries
Publikováno v:
Vaccine. 14:428-434
Avian poxvirus recombinants undergo abortive replication in nonavian cells, yet can achieve expression of extrinsic gene products. Canarypox-vectored vaccines have been innocuous and immunogenic in several mammalian species. ALVAC-RG, a canarypox rec