Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Enyuan Shang"'
Autor:
Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidat
Externí odkaz:
https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce7
Autor:
Trang T. T. Nguyen, Enyuan Shang, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Cells, Vol 11, Iss 19, p 2956 (2022)
Glioblastoma WHO IV (GBM), the most common primary brain tumor in adults, is a heterogenous malignancy that displays a reprogrammed metabolism with various fuel sources at its disposal. Tumor cells primarily appear to consume glucose to entertain the
Externí odkaz:
https://doaj.org/article/6e8b0421946c41be8f3385af3f0def5d
Autor:
Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults. However, given that tumors become commonly resistant to single treatments,
Externí odkaz:
https://doaj.org/article/ba23ac173ed440d99429cc6ecf60572d
Autor:
Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with globa
Externí odkaz:
https://doaj.org/article/34407949ed7c4e12861f0104f22e7368
Autor:
Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Cells, Vol 9, Iss 7, p 1661 (2020)
The heterogeneity of glioblastomas, the most common primary malignant brain tumor, remains a significant challenge for the treatment of these devastating tumors. Therefore, novel combination treatments are warranted. Here, we showed that the combined
Externí odkaz:
https://doaj.org/article/74dca1f5fdd9484e9835305617dbdef9
Autor:
Enyuan Shang, Katherine Lai, Alan I. Packer, Jisun Paik, William S. Blaner, Milena de Morais Vieira, Peter Gouras, Debra J. Wolgemuth
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 4, Pp 590-597 (2002)
It has been proposed that cis-retinol dehydrogenase (cRDH) acts within the body to catalyze the oxidation of 9-cis-retinol, an oxidative step needed for 9-cis-retinoic acid synthesis, the oxidation of 11-cis-retinol [an oxidative step needed for 11-c
Externí odkaz:
https://doaj.org/article/91abeda609fd4a21ad8c4914fbb57c1c
Autor:
Mary V. Gamble, Enyuan Shang, Roseann Piantedosi Zott, James R. Mertz, Debra J. Wolgemuth, William S. Blaner
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 12, Pp 2279-2292 (1999)
We have identified a retinol dehydrogenase (cRDH) that catalyzes the oxidation of 9-cis- but not all-trans-retinol and proposed that this enzyme plays an important role in synthesis of the transcriptionally active retinoid, 9-cis-retinoic acid. There
Externí odkaz:
https://doaj.org/article/e432aeefdcd34c029cba0351ffea3e3c
Autor:
Libor Velíšek, Enyuan Shang, Jana Velíšková, Tamar Chachua, Stephania Macchiarulo, Giorgi Maglakelidze, Debra J Wolgemuth, David A Greenberg
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23656 (2011)
Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression. Multiple linkage and population association studies have connected the bromo
Externí odkaz:
https://doaj.org/article/b35688e638374321aa40bddf05b34973
Autor:
Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Publikováno v:
Oncotarget. 14:419-425
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
Figure S1. Crizotinib resistant cells reveal a reprogrammed tumor metabolism. Figure S2. Crizotinib modulates fatty acid metabolism and mitochondrial parameters. Figure S3. Tracing analysis reveals distinct modulation of metabolism by MET inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ca270b2531ae2a9908279f0411cd4
https://doi.org/10.1158/0008-5472.22423917.v1
https://doi.org/10.1158/0008-5472.22423917.v1