Effects of induction chemotherapy on nutrition status in locally advanced nasopharyngeal carcinoma: a multicentre prospective study

Autor: Jingjing Miao, Lin Wang, Enya H.W. Ong, Chaosu Hu, Shaojun Lin, Xiaozhong Chen, Yuanyuan Chen, Yahua Zhong, Feng Jin, Qin Lin, Shaomin Lin, Xuefeng Hu, Ning Zhang, Rensheng Wang, Cong Wang, Xiang Guo, Nelson L.F. Yit, Hanping Shi, Sze Huey Tan, Haiqiang Mai, Conghua Xie, Melvin L.K. Chua, Chong Zhao

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 2, Pp 815-825 (2023)

Abstract Background Induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT) is the standard of care for locoregionally advanced nasopharyngeal carcinoma (LA‐NPC). This intensive treatment regimen increases acute toxicities, which could

Externí odkaz: https://doaj.org/article/339f6599500c464f86865d0157dab120

Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer

Autor: Elnaz Naderi, Line M.H. Schack, Ceilidh Welsh, Adelene Y.L. Sim, Miguel E. Aguado-Barrera, Tom Dudding, Holly Summersgil, Laura Martínez-Calvo, Enya H.W. Ong, Yasmin Odding, Ana Varela-Pazos, Roel J.H.M. Steenbakkers, Anne P.G. Crijns, Rajesh Jena, Miranda Pring, Joe Dennis, Ramón Lobato-Busto, Jan Alsner, Andy Ness, Christopher Nutting, David J Thomson, Antonio Gómez-Caamaño, Jesper G. Eriksen, Steve J. Thomas, Amy M. Bates, Jens Overgaard, Luis M. Cascallar-Caneda, Fréderic Duprez, Gillian C. Barnett, Leila Dorling, Melvin L.K. Chua, Ana Vega, Catharine M.L. West, Johannes A. Langendijk, Christian Nicolaj Andreassen, Behrooz Z. Alizadeh

Publikováno v: On the behalf of the Radiogenomics Consortium 2022, ' Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer ', Radiotherapy and Oncology, vol. 176, pp. 138-148 . https://doi.org/10.1016/j.radonc.2022.09.016
Radiotherapy and Oncology, 176, 138-148. ELSEVIER IRELAND LTD
2022, ' Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer ', Radiotherapy and Oncology, vol. 176, pp. 138-148 . https://doi.org/10.1016/j.radonc.2022.09.016

Background and purpose: We aimed to the genetic components and susceptibility variants associated with acute radiation-induced toxicities (RITs) in patients with head and neck cancer (HNC).Materials and methods: We performed the largest meta-GWAS of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4cfa41ad874e5430d290fa08f8c16b
https://pure.au.dk/portal/da/publications/metagwas-identifies-the-heritability-of-acute-radiationinduced-toxicities-in-head-and-neck-cancer(36138fe1-aec2-4815-9b13-ff37414e15e1).html

Development of a risk classification system combining TN-categories and circulating EBV DNA for non-metastatic NPC in 10,149 endemic cases

Autor: Sze Huey Tan, Ying-Shan Luo, Jia Kou, Bin Deng, Li Lin, Tian-Sheng Gao, Fo-Ping Chen, Ying Sun, Jin-Hui Liang, Melvin L.K. Chua, Haitao Wang, Adelene Y.L. Sim, Enya H.W. Ong, Guan-Qun Zhou, Luo Huang

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Therapeutic Advances in Medical Oncology

Background: The objective of this study was to construct a risk classification system integrating cell-free Epstein-Barr virus (cfEBV) DNA with T- and N- categories for better prognostication in nasopharyngeal carcinoma (NPC). Methods: Clinical recor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef2303b806b84ed9a3ba0c468e30086
https://doaj.org/article/20e9d883c6ba463eac870ea0a829a921

An Immune-Based Genomic Classifier (GC) Prognosticates for Survival in Endemic Nasopharyngeal Carcinoma

Autor: Jin-Xin Bei, Joseph Wee, Luo Huang, J.S.G. Hwang, M.L.K. Chua, Mohamed E. Abazeed, Kar Perng Low, K.W. Fong, N G Iyer, Adelene Y.L. Sim, Enya H.W. Ong, S Y Lim, Gek San Tan, Tse Hui Lim, D.W.T. Lim, T.W.K. Tan

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 111:e382-e383

PURPOSE/OBJECTIVE(S) Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer that is associated with Epstein-Barr virus (EBV). Its histomorphology is characterized by epithelial carcinoma that is admixed with immune cells. This cellular pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccda821e90bf44fca549d1fdbd767659
https://doi.org/10.1016/j.ijrobp.2021.07.1121

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome‐Wide Association Study in Multiple Cohorts

Autor: Yun-Miao Guo, Josephine Mun Yee Ko, Xiao‐Yu Zuo, Yanni Zeng, Qi Sheng Feng, Maria Li Lung, Yun-Fei Xia, Jie-Rong Chen, Qian Cui, Hui‐Qiong Han, Wan Peng, Xiaojun Xia, Yan Liang, Tony Kiat Hon Lim, Chu-Jun Liu, Kar Perng Low, Eugenia Li Ling Yeo, Guo-Wang Lin, Chun-Ling Luo, Zhong‐Lian He, Mu Sheng Zeng, Allen K.C. Chan, Hai-Qiang Mai, Yi Xin Zeng, Yu-Xiang Liu, Jianjun Liu, Jin-Xin Bei, Yang Liu, Anthony T.C. Chan, Lin-Quan Tang, Gek San Tan, Pan-Pan Wei, Enya H.W. Ong, Lin Wang, Yan-Chun Feng, Bo-Wei Han, Melvin L.K. Chua, Dennis Lo, Bo Li, Jacqueline S.G. Hwang, Edwin P. Hui, Wei Dai

Publikováno v: Advanced Science, Vol 7, Iss 10, Pp n/a-n/a (2020)
Advanced Science

Germline polymorphisms are linked with differential survival outcomes in cancers but are not well studied in nasopharyngeal carcinoma (NPC). Here, a two‐phase association study is conducted to discover germline polymorphisms that are associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8c7e7b1155c6af0f1fcd8304764457
https://doi.org/10.1002/advs.201903727