Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Enxuan Jing"'
Autor:
Kian Huat Lim, Zhou Han, Hyun Yong Jeon, Jacob Kach, Enxuan Jing, Sebastien Weyn-Vanhentenryck, Mikaela Downs, Anna Corrionero, Raymond Oh, Juergen Scharner, Aditya Venkatesh, Sophina Ji, Gene Liau, Barry Ticho, Huw Nash, Isabel Aznarez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Restoration of normal gene expression is one way to treat monogenic disorders. Here the authors target naturally occurring non-productive alternative splicing using antisense oligonucleotides to promote the production of functional proteins.
Externí odkaz:
https://doaj.org/article/b4b17242c1b24dc9905cc03dd97077f2
Autor:
Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J. Mendez, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain
Publikováno v:
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insuli
Externí odkaz:
https://doaj.org/article/d75f9c8e8cd84ed48bbe767a8e883d40
Autor:
Huw M. Nash, Barry Ticho, Juergen Scharner, Mikaela Downs, Hyun Yong Jeon, Sebastien M. Weyn-Vanhentenryck, Sophina Ji, Anna Corrionero, Isabel Aznarez, Enxuan Jing, Kian-Huat Lim, Jacob Kach, Aditya Venkatesh, Zhou Han, Raymond S Oh, Gene Liau
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can selectively increase levels of protein in native tissues remains. Here we demonstrate that antisense-mediated modulation of pre-mRNA
Autor:
Enxuan Jing, Pragalath Sundararajan, Ishita Majumdar, Suwagmani Hazarika, Fowler, Samantha, Szeto, Angela, Stephane Gesta, Mendez, Armando, Vishnudas, Vivek, Rangaprasad Sarangarajan, Niven Narain
Hsp90ab1 ASO treatment does not significantly affect protein expression in the liver. Male mice were fed a high fat diet (DIO) for 12 weeks prior to receiving either negative control (NC) ASO or Hsp90ab1 ASO 10μg/kg/day two times a week for 4 weeks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccec21e1163f71a0608c738cc60b3ea
Autor:
Vivek K. Vishnudas, Samantha Fowler, Angela Szeto, Suwagmani Hazarika, Enxuan Jing, Stephane Gesta, Pragalath Sundararajan, Niven R. Narain, Rangaprasad Sarangarajan, Armando J. Mendez, Ishita Deb Majumdar
Publikováno v:
Nutrition & metabolism, 15:11
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-10 (2018)
Nutrition & Metabolism
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-10 (2018)
Nutrition & Metabolism
Background Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d05d5d3a64dd0361a959aca0a6f66a2
https://repository.publisso.de/resource/frl:6417772
https://repository.publisso.de/resource/frl:6417772
Autor:
Enxuan Jing, Pragalath Sundararajan, Ishita Majumdar, Suwagmani Hazarika, Fowler, Samantha, Szeto, Angela, Stephane Gesta, Mendez, Armando, Vishnudas, Vivek, Rangaprasad Sarangarajan, Niven Narain
Knockdown of Hsp90ab1 decreases PDH catalytic subunit phosphorylation. Skeletal muscle of DIO mice were analyzed by Western blot after 4 weeks antisense oligonucleotide (ASO) treatment at 10μg/kg/day. Phosphorylation of PDH E1α was examined at seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a7d7728b9df8c27cd5f24ea26d7f05
Autor:
Kevin Y. Lee, C. Ronald Kahn, Christopher B. Newgard, Enxuan Jing, Matthew J. Rardin, Olga R. Ilkeyeva, Bradford W. Gibson, James R. Bain, Siegfried Ussar, Eric Verdin, Brian T. O’Neill, André Kleinridders
Publikováno v:
Diabetes
Sirt3 is an NAD+-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Dele
Autor:
Christine C. Wu, Matthew J. Rardin, Eric Verdin, Michael J. MacCoss, Bradford W. Gibson, Anna M. Zawadzka, Michael S. Bereman, Michael P. Cusack, C. Ronald Kahn, Enxuan Jing, Brendan MacLean, Barbara Frewen, Dylan J. Sorensen, Birgit Schilling
Publikováno v:
Molecular & Cellular Proteomics. 11:202-214
Despite advances in metabolic and postmetabolic labeling methods for quantitative proteomics, there remains a need for improved label-free approaches. This need is particularly pressing for workflows that incorporate affinity enrichment at the peptid
Autor:
Daniel Espinoza, Efi Kokkotou, Ryo Suzuki, Tong-Chuan He, Yu-Hua Tseng, Cullen M. Taniguchi, Hongbin Zhang, Kevin Y. Lee, Enxuan Jing, Tian Lian Huang, Tim J. Schulz, Kristy L. Townsend, Lindsay E. McDougall
Publikováno v:
The FASEB Journal. 26:2187-2196
Body weight is regulated by coordinating energy intake and energy expenditure. Transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP) signaling has been shown to regulate energy balance in lower organisms, but whether a similar pathwa
Autor:
Jeremie Boucher, Brice Emanuelli, Matthew D. Hirschey, David B. Lombard, Eric Verdin, Kevin Y. Lee, C. Ronald Kahn, Enxuan Jing
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14608-14613
Sirt3 is a member of the sirtuin family of protein deacetylases that is localized in mitochondria and regulates mitochondrial function. Sirt3 expression in skeletal muscle is decreased in models of type 1 and type 2 diabetes and regulated by feeding,