Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy.

Autor: Klenchin VA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, WI, 53705, USA., Clark NM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, WI, 53705, USA., Keles NK; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, WI, 53705, USA., Capuano S; Wisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, WI, 53715, USA., Mason R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, 20892, USA., Gao G; Deparment of Microbiology and Physiological Systems, University of Massachusetts Medical School; Worcester, MA, 01605, USA., Broman A; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison; Madison, WI, 53705, USA., Kose E; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research; Frederick, MD, 21702, USA., Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research; Frederick, MD, 21702, USA., Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research; Frederick, MD, 21702, USA., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research; Frederick, MD, 21702, USA., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research; Frederick, MD, 21702, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, 20892, USA., Gardner MR; Division of Infectious Diseases, Department of Medicine, Emory University; Atlanta, GA, 30329, USA.; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA., Evans DT; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, WI, 53705, USA.; Wisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, WI, 53715, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03.

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Autor: Brittani M. Barrows, Shelly J. Krebs, Ningbo Jian, Michelle Zemil, Bonnie M. Slike, Vincent Dussupt, Ursula Tran, Letzibeth Mendez-Rivera, David Chang, Anne Marie O’Sullivan, Brendan Mann, Eric Sanders-Buell, Zhanna Shubin, Matt Creegan, Dominic Paquin-Proulx, Philip Ehrenberg, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Guido Ferrari, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluate

Externí odkaz: https://doaj.org/article/cf38bdf7a92d429dbb06fe53fdb887b3

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Env-Specific Antibodies in Chronic Infection versus in Vaccination

Autor: Martina Soldemo, Gunilla B. Karlsson Hedestam

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Antibodies are central in vaccine-mediated protection. For HIV-1, a pathogen that displays extreme antigenic variability, B cell responses against conserved determinants of the envelope glycoproteins (Env) are likely required to achieve broadly prote

Externí odkaz: https://doaj.org/article/ed63221adc5945bda2424070af98da17