Zobrazeno 1 - 10
of 1 760
pro vyhledávání: '"Entry inhibitor"'
Autor:
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selectiv
Externí odkaz:
https://doaj.org/article/c3903556c3ab42faabeedc9cf418281c
Autor:
Nasim Shahhamzehei, Sara Abdelfatah, Hannah S. Schwarzer-Sperber, Kathrin Sutter, Rümeysa Yücer, Gerhard Bringmann, Roland Schwarzer, Thomas Efferth
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117517- (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of infections and deaths worldwide since its emergence in Wuhan, China, in late 2019. Natural product inhibitors targeting the interaction between the receptor-binding d
Externí odkaz:
https://doaj.org/article/0507e9be234841779b76b8c67e1a3a88
Autor:
Alexander Killer, Smaranda Gliga, Carolin Lohr, Christian Weigel, Björn-Erik Ole Jensen, Nadine Lübke, Andreas Walker, Jörg Timm, Johannes Bode, Tom Luedde, Hans H. Bock
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 3, Pp 353-360 (2024)
Background and Aims: The entry inhibitor bulevirtide represents the first specific treatment for hepatitis-D virus (HDV)-infected patients. In clinical trials, around 80% of patients achieve normalization of alanine aminotransferase (ALT) with about
Externí odkaz:
https://doaj.org/article/20cc424499e749c1ab58893002175fbd
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The COVID-19 pandemic has had a significant and lasting impact on the world. Four years on, despite the existence of effective vaccines, the continuous emergence of new SARS-CoV-2 variants remains a challenge for long-term immunity. Additionally, the
Externí odkaz:
https://doaj.org/article/cf277f09607f48dd9aadb6568e095665
Ergosterol peroxide blocks HDV infection as a novel entry inhibitor by targeting human NTCP receptor
Autor:
Wei-Chung Chiou, Yi-Syuan Lyu, Tzu-Lan Hsia, Jui-Chieh Chen, Lie-Chwen Lin, Ming-Fu Chang, Meng-Shiuan Hsu, Cheng Huang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116077- (2024)
Hepatitis D virus (HDV), which co-infects or superinfects patients with hepatitis B virus, is estimated to affect 74 million people worldwide. Chronic hepatitis D is the most severe form of viral hepatitis and can result in liver cirrhosis, liver fai
Externí odkaz:
https://doaj.org/article/0620cf758b2f4496a7c9cf3298e3fa23
Autor:
Xinling Wang, Lujia Sun, Zezhong Liu, Lixiao Xing, Yun Zhu, Wei Xu, Shuai Xia, Lu Lu, Shibo Jiang
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The threat to global health caused by three highly pathogenic human coronaviruses (HCoV), SARS-CoV-2, MERS-CoV and SARS-CoV, calls for the development of pan-HCoV therapeutics and vaccines. This study reports the design and engineering of a recombina
Externí odkaz:
https://doaj.org/article/f63b90c1d24c4785b7803be4cbbbeed0
Autor:
Matthew R. Freidel, Roger S. Armen
Publikováno v:
Viruses, Vol 16, Iss 5, p 712 (2024)
Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim to review research progress on small-molecule viral entry and fusion in
Externí odkaz:
https://doaj.org/article/e91d90199bf34322a523acb51a0a3343
Publikováno v:
Viruses, Vol 16, Iss 2, p 231 (2024)
In the realm of clinical practice, nucleoside analogs are the prevailing antiviral drugs employed to combat feline herpesvirus-1 (FHV-1) infections. However, these drugs, initially formulated for herpes simplex virus (HSV) infections, operate through
Externí odkaz:
https://doaj.org/article/922f8094d89247ae961b40cd78459339
Autor:
Pietro Lampertico, Elisabetta Degasperi, Lisa Sandmann, Heiner Wedemeyer, Cihan Yurdaydin, Dominique Roulot, Fabien Zoulim, Florin Alexandru Caruntu, Helenie Kefalakes, Julie Lucifora, Kosh Agarwal, Laurent Castera, Maria Buti, Mario Rizzetto, Markus Cornberg, Maura Dandri, Maurizia Brunetto, Nancy Reau, Robert Gish, Saeed Hamid, Soo Aleman, Stephan Urban, Tarik Asselah, Thomas Berg, Victor de Lédinghen
Publikováno v:
JHEP Reports, Vol 5, Iss 9, Pp 100818- (2023)
Summary: Chronic infection with hepatitis delta virus (HDV) affects between 12-20 million people worldwide and represents the most severe form of viral hepatitis, leading to accelerated liver disease progression, cirrhosis and its complications, such
Externí odkaz:
https://doaj.org/article/605a659388844615aca120322bfbfeb7
Autor:
Cecilia Abreu, Claudia Ortega, Natalia Olivero-Deibe, Federico Carrión, Aracelly Gaete-Argel, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Rafaela Milan Bonotto, Alessandro Marcello, Sergio Pantano
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The COVID-19 pandemic evolves constantly, requiring adaptable solutions to combat emerging SARS-CoV-2 variants. To address this, we created a pentameric scaffold based on a mammalian protein, which can be customized with up to 10 protein binding modu
Externí odkaz:
https://doaj.org/article/ee93bdde5a7444b6aa668d328feb22ee