Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Enrique de Alava"'
Autor:
Nadia Mensali, Hakan Köksal, Sandy Joaquina, Patrik Wernhoff, Nicholas P. Casey, Paola Romecin, Carla Panisello, René Rodriguez, Lene Vimeux, Asta Juzeniene, Marit R. Myhre, Anne Fåne, Carolina Castilla Ramírez, Solrun Melkorka Maggadottir, Adil Doganay Duru, Anna-Maria Georgoudaki, Iwona Grad, Andrés Daniel Maturana, Gustav Gaudernack, Gunnar Kvalheim, Angel M. Carcaboso, Enrique de Alava, Emmanuel Donnadieu, Øyvind S. Bruland, Pablo Menendez, Else Marit Inderberg, Sébastien Wälchli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and
Externí odkaz:
https://doaj.org/article/aeb35d7698f54300a9d32846913690b0
Autor:
Inmaculada Ruiz-Cáceres, Teresa Hermida Romero, Isabel Guerra Merino, Joseba Portu Zapirain, Belén Pérez-Mies, Matilde Sánchez-Conde, Marina Alonso Riaño, Rafael Rubio, Jose Fortés Alen, Ánxela Vidal González, Clara Salas Antón, Elena Múñez, Rafael Sánchez Sánchez, Diana Corona-Mata, Iban Aldecoa Ansorregui, José M. Miró, Raquel Beloqui Pérez de Obanos, Carlos Ibero, Javier Gómez-Román, M. Carmen Fariñas, Teresa Tabuyo Bello, Enrique de Alava, José Miguel Cisneros, Xavier Matías-Guiu, Antonio Rivero, on behalf of the NECROCOVID Study Group
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections.MethodsThis
Externí odkaz:
https://doaj.org/article/797df60dfcd246388876ed4ca3facd56
Autor:
Jose Alejandro Pérez-Fidalgo, Eugenia Ortega, Jordi Ponce, Andres Redondo, Isabel Sevilla, Claudia Valverde, Josep Isern Verdum, Enrique de Alava, Mar Galera López, Gloria Marquina, Ana Sebio
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Uterine sarcomas are very infrequent and heterogeneous entities. Due to its rarity, pathological diagnosis, surgical management, and systemic treatment are challenging. Treatment decision process in these tumors should be taken in a multidisciplinary
Externí odkaz:
https://doaj.org/article/aaf4e864ae8949438bd7f63f170a8840
Autor:
Giorgia Sonzini, Sofia Granados-Aparici, Sabina Sanegre, Angel Diaz-Lagares, Juan Diaz-Martin, Carlos de Andrea, Núria Eritja, Aida Bao-Caamano, Nicolás Costa-Fraga, David García-Ros, Carmen Salguero-Aranda, Ben Davidson, Rafael López-López, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The incidence of new cancer cases is expected to increase significantly in the future, posing a worldwide problem. In this regard, precision oncology and its diagnostic tools are essential for developing personalized cancer treatments. Digital pathol
Externí odkaz:
https://doaj.org/article/1debe2f1f3eb466fb9188e4c9d95f9d3
Autor:
Sabina Sanegre, Núria Eritja, Carlos de Andrea, Juan Diaz-Martin, Ángel Diaz-Lagares, María Amalia Jácome, Carmen Salguero-Aranda, David García Ros, Ben Davidson, Rafel Lopez, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted fact
Externí odkaz:
https://doaj.org/article/743805c8e0f34b5ba6114838c5cfc6a8
Autor:
Javier Martin-Broto, Paola Collini, Javier Martinez-Trufero, Antonio Lopez-Pousa, Lorenzo D'Ambrosio, Antonio Gutierrez, Herminia Perez-Vega, Victor Encinas-Tobajas, Enrique de Alava, Maria Peña-Chilet, Irene Carrasco-Garcia, Maria Lopez-Alvarez, David S Moura
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As t
Externí odkaz:
https://doaj.org/article/ba0c92285ab347e788e84cf5c6815dde
Autor:
Miguel Sáinz-Jaspeado, Juan Huertas-Martinez, Laura Lagares-Tena, Juan Martin Liberal, Silvia Mateo-Lozano, Enrique de Alava, Carmen de Torres, Jaume Mora, Xavier Garcia Del Muro, Oscar M Tirado
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71449 (2013)
Angiogenesis is the result of the combined activity of the tumor microenvironment and signaling molecules. The angiogenic switch is represented as an imbalance between pro- and anti-angiogenic factors and is a rate-limiting step in the development of
Externí odkaz:
https://doaj.org/article/bf8904e1fd0d4946ad6240ae7db0e1e3
Autor:
Ana Sofia Martins, José Luis Ordóñez, Ana Teresa Amaral, Frans Prins, Giuseppe Floris, Maria Debiec-Rychter, Pancras C W Hogendoorn, Enrique de Alava
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19846 (2011)
Receptor endocytosis is critical for cell signaling. IGF1R mediates an autocrine loop that is de-regulated in Ewing Sarcoma (ES) cells. Here we study the impact of IGF1R internalization, mediated by clathrin and caveolin-1 (CAV1), in ES signaling. We
Externí odkaz:
https://doaj.org/article/70a9af3bc756495fab7e93621e7fa4c3
Autor:
Joaquin Olmedo-Pelayo, Esperanza Lisha Granado-Calle, Daniel Delgado-Bellido, Laura Lobo-Selma, Carmen Jordan-Perez, Ana Teresa Monteiro-Amaral, Anna C Ehlers, Shunya Ohmura, Angel Montero Carcaboso, Javier Alonso, Isidro Machado, Antonio Llombart-Bosch, Thomas G. P. Grunewald, Fernando Gomez-Herreros, Enrique de Alava
Drug resistance is one of the major factors associated with poor outcome of cancer patients. Treatment of Ewing sarcoma (EwS), an aggressive neoplasm mainly affecting children, adolescents and young adults, is associated with therapy failure and tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c20105e3449b1f4ecf0e0e5266663cc
https://doi.org/10.1101/2023.05.30.542894
https://doi.org/10.1101/2023.05.30.542894
Autor:
Enrique de Alava, María Jesús Pareja, David Carcedo, Natalia Arrabal, José-Francisco García, Reyes Bernabé-Caro
Publikováno v:
Expert Review of Pharmacoeconomics & Outcomes Research. 22:1033-1042
[Background] To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing (SST) for molecular diagnostic and treatment of patients with advanced non-small cell lung cancer (NSCLC) from a Spanish sin