Zobrazeno 1 - 10
of 603
pro vyhledávání: '"Enrique Rozengurt"'
Autor:
Yaroslav Teper, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, Guido Eibl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies
Externí odkaz:
https://doaj.org/article/6608e1bba2a74358ac50303e509a41fb
Autor:
Richard T. Waldron, Aurelia Lugea, Hui-Hua Chang, Hsin-Yuan Su, Crystal Quiros, Michael S. Lewis, Mingtian Che, V. Krishnan Ramanujan, Enrique Rozengurt, Guido Eibl, Stephen J. Pandol
Publikováno v:
Cancers, Vol 16, Iss 8, p 1593 (2024)
Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic ana
Externí odkaz:
https://doaj.org/article/710601d70c5b44aaaab53d5b3b62bd8a
Autor:
Soichiro Ako, Yaroslav Teper, Linda Ye, James Sinnett-Smith, Oscar J. Hines, Enrique Rozengurt, Guido Eibl
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 4, Pp 640-651 (2022)
Background and Aims: Animal data show that the presence of an oncogenic Kras mutation in pancreatic acinar cells leads to acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasia (PanIN), and pancreatic ductal adenocarcinoma (PDAC). In
Externí odkaz:
https://doaj.org/article/c41f39bee00641df9ed62f72e42bc5ec
Autor:
Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt, Guido Eibl
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in the adipose tissue. HSL has been implicated to play a role in tumor cac
Externí odkaz:
https://doaj.org/article/07afe0ee8ea74324a7e7d940b7b07fe2
Autor:
Guido Eibl, Enrique Rozengurt
Publikováno v:
Cancers, Vol 13, Iss 20, p 5067 (2021)
The prevalence of obesity in adults and children has dramatically increased over the past decades. Obesity has been declared a chronic progressive disease and is a risk factor for a number of metabolic, inflammatory, and neoplastic diseases. There is
Externí odkaz:
https://doaj.org/article/7a4dc26cc6a0403b8a840e3b459ccdf0
Autor:
Enrique Rozengurt, Guido Eibl
Publikováno v:
Cancers, Vol 13, Iss 20, p 5126 (2021)
Pancreatic ductal adenocarcinoma (PDAC), the predominant form of pancreatic cancer, remains a devastating disease. The purpose of this review is to highlight recent literature on mechanistic and translational developments that advance our understandi
Externí odkaz:
https://doaj.org/article/854c320b072948bc9a70671faaa2569e
Autor:
Fang Hao, Qinhong Xu, Jing Wang, Shuo Yu, Hui-Hua Chang, James Sinnett-Smith, Guido Eibl, Enrique Rozengurt
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216603 (2019)
We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells. Exposure of sparse cultures of PANC-1 and MiaPaCa-2 cells t
Externí odkaz:
https://doaj.org/article/fa5a88971cf444c8bf64d60253d7c445
Autor:
Hui-Hua Chang, Aune Moro, Kazuki Takakura, Hsin-Yuan Su, Allen Mo, Masako Nakanishi, Richard T Waldron, Samuel W French, David W Dawson, O Joe Hines, Gang Li, Vay Liang W Go, James Sinnett-Smith, Stephen J Pandol, Aurelia Lugea, Anna S Gukovskaya, Michael O Duff, Daniel W Rosenberg, Enrique Rozengurt, Guido Eibl
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184455 (2017)
Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic cancer, a hi
Externí odkaz:
https://doaj.org/article/65f6fd5020ab4c38a849f10b7bae4ca6
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/35146e6c2c26411193a304fc75b7303d
Autor:
Ming Ming, James Sinnett-Smith, Jia Wang, Heloisa P Soares, Steven H Young, Guido Eibl, Enrique Rozengurt
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114573 (2014)
Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti-proliferative and chemopreventive properties. Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with the
Externí odkaz:
https://doaj.org/article/4e0bff5184be43bdbc5c7d44e9f9cd8d