Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Enrique Portillo-Salido"'
Autor:
Luz Romero, Enrique Portillo-Salido
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Purpose: There are previous reviews focused on Sigma-1 receptor but no bibliometric studies examining this field as a whole. This article aims to present a global view of Sigma-1 receptor research and its intellectual structure.Methods: We used bibli
Externí odkaz:
https://doaj.org/article/1ee16c51bb094b689498b9a5c31b0b06
Autor:
Ariadna Fernández, Enrique Portillo-Salido, Mónica Porras, Adriana Lorente, José Miguel Vela, Carmen Almansa, Raquel Enrech, J.L. Diaz, Begoña Fernández, Albert Dordal, Sergi Rodríguez-Escrich, Raquel F. Reinoso, Mónica García
Publikováno v:
ACS Med Chem Lett
[Image: see text] The synthesis and pharmacological activities of a new series of piperazinyl quinazolin-4-(3H)-one derivatives acting toward the α2δ-1 subunit of voltage-gated calcium channels (Ca(v)α2δ-1) are reported. Different positions of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ebf310cb9bbc8e97f822502f72c2b
https://doi.org/10.1021/acsmedchemlett.1c00416
https://doi.org/10.1021/acsmedchemlett.1c00416
Autor:
Magda Bordas, Virginia Llorente, Javier Burgueño, Enrique Portillo-Salido, Begoña Fernández, Mónica García, Carmen Almansa, Marta Pujol, Sergi Rodríguez-Escrich, Lourdes Garriga, Georgia Gris, Albert Dordal, Eva Ayet, Ute Christmann, Marina Virgili, José Miguel Vela
Publikováno v:
Journal of Medicinal Chemistry. 64:10139-10154
A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ1 receptor antagonists. Modification of a high-throughput screening hit originated a series of piperazinylcycloalkylmethyl propionamides, which were expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6283a8192c91d9c5578b53eb7b1cb388
https://doi.org/10.1021/acs.jmedchem.1c00417
https://doi.org/10.1021/acs.jmedchem.1c00417
Autor:
Enrique Portillo-Salido, Agustín Jiménez-Aquino, José Miguel Vela, Ana I. Oliva, Adriana Port, Gonzalo Pazos, Félix Cuevas, María Morón, Carmen Almansa, J.L. Diaz, Albert Dordal, Daniel Font, Raquel F. Reinoso, Paula Álvarez-Bercedo, M. Ángeles Sarmentero, Rosalia Pascual
Publikováno v:
Journal of Medicinal Chemistry. 64:2167-2185
The synthesis and pharmacological activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e44c54c3e5563d8ad6c2a2f01a1d4d
https://doi.org/10.1021/acs.jmedchem.0c01867
https://doi.org/10.1021/acs.jmedchem.0c01867
Autor:
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela, Manuel Merlos, Enrique Portillo-Salido
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Chronic pain remains a major health problem and is currently facing slow drug innovation. New drug treatments should address not only the sensory-discriminative but also functional and motivational-affective components of chronic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73b26d29d9fc1fe08817532f8a40817
https://pubmed.ncbi.nlm.nih.gov/35434530
https://pubmed.ncbi.nlm.nih.gov/35434530
Autor:
Agustín Salguero, Leonardo Marengo, Enrique Portillo-Salido, Leandro Ruiz-Leyva, Cruz Miguel Cendán, Ignacio Morón Henche, Ricardo Marcos Pautassi
Publikováno v:
Neuroscience letters. 778
Ethanol-induced conditioned taste aversion (CTA) is greater in late adolescence or young adulthood than in early adolescence. The role of the sigma receptor system in this age-related difference has not been extensively explored, particularly in fema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d993114b295c7121dfc80ebea01145d
https://pubmed.ncbi.nlm.nih.gov/35318075
https://pubmed.ncbi.nlm.nih.gov/35318075
Autor:
Mónica, García, Virginia, Llorente, Lourdes, Garriga, Ute, Christmann, Sergi, Rodríguez-Escrich, Marina, Virgili, Begoña, Fernández, Magda, Bordas, Eva, Ayet, Javier, Burgueño, Marta, Pujol, Albert, Dordal, Enrique, Portillo-Salido, Georgia, Gris, José Miguel, Vela, Carmen, Almansa
Publikováno v:
Journal of medicinal chemistry. 64(14)
A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55020aa55f57caec684d484acdf8ccbd
https://pubmed.ncbi.nlm.nih.gov/34236190
https://pubmed.ncbi.nlm.nih.gov/34236190
Autor:
Luz Romero, Xavier Codony, José Miguel Vela, Bertrand Aubel, Daniel Zamanillo, Jordi Buxens, Enrique Portillo-Salido, Angels Fisas, Manuel Merlos, Alex Brenchat
Publikováno v:
European Journal of Pharmacology. 833:370-378
Drug combination for the treatment of pain is common clinical practice. Co-crystal of Tramadol-Celecoxib (CTC) consists of two active pharmaceutical ingredients (APIs), namely the atypical opioid tramadol and the preferential cyclooxygenase-2 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539ceea04d866f85ce6c871ac98e0c0c
https://doi.org/10.1016/j.ejphar.2018.06.022
https://doi.org/10.1016/j.ejphar.2018.06.022
Autor:
Leandro Ruiz-Leyva, Agustín Salguero, Enrique Portillo-Salido, Ignacio Morón, Ricardo Marcos Pautassi, Cruz Miguel Cendán
Publikováno v:
Drug and Alcohol Dependence. 215:108214
Background Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e247627a6c65f54e5841f482880bc9ec
https://doi.org/10.1016/j.drugalcdep.2020.108214
https://doi.org/10.1016/j.drugalcdep.2020.108214
Autor:
Enrique Portillo-Salido, Beatriz de la Puente, Daniel Zamanillo, José Miguel Vela, Manuel Merlos, Luz Romero
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Pain encompasses both sensory and affective dimensions which can be differentially modulated by drugs. Here, we compare the pharmacological sensitivity of the sensory and affective responses using acetic acid-induced abdominal writhings (sensory-refl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31b9329e2b4cd3643ffbccd183464a
https://doi.org/10.1038/s41598-017-13987-9
https://doi.org/10.1038/s41598-017-13987-9