Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Enrique Martinez-Perez"'
Autor:
Maikel Castellano-Pozo, Georgios Sioutas, Consuelo Barroso, Josh P Prince, Pablo Lopez-Jimenez, Joseph Davy, Angel-Luis Jaso-Tamame, Oliver Crawley, Nan Shao, Jesus Page, Enrique Martinez-Perez
Publikováno v:
eLife, Vol 12 (2023)
The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesi
Externí odkaz:
https://doaj.org/article/1235e182b1454f73a8f6a72952cf9905
Autor:
Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010666 (2023)
Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1,
Externí odkaz:
https://doaj.org/article/256d8d7b5f334b59810c1d4d8aae4a05
Autor:
Karen P McNally, Elizabeth A Beath, Brennan M Danlasky, Consuelo Barroso, Ting Gong, Wenzhe Li, Enrique Martinez-Perez, Francis J McNally
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010136 (2022)
Accurate chromosome segregation requires a cohesin-mediated physical attachment between chromosomes that are to be segregated apart, and a bipolar spindle with microtubule plus ends emanating from exactly two poles toward the paired chromosomes. We a
Externí odkaz:
https://doaj.org/article/8a80bd3aaa3e4fb3bcc091f424568ecf
Autor:
Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H. Dore, Mohammad M. Karimi, Enrique Martinez-Perez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a m
Externí odkaz:
https://doaj.org/article/ca7beece05774737bac58f1c2cc21c92
Autor:
Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010025 (2022)
Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular
Externí odkaz:
https://doaj.org/article/a96ac9391b0141f5855e9de298dde95f
Autor:
Aya Sato-Carlton, Chihiro Nakamura-Tabuchi, Xuan Li, Hendrik Boog, Madison K Lehmer, Scott C Rosenberg, Consuelo Barroso, Enrique Martinez-Perez, Kevin D Corbett, Peter Mark Carlton
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1008968 (2020)
In the two cell divisions of meiosis, diploid genomes are reduced into complementary haploid sets through the discrete, two-step removal of chromosome cohesion, a task carried out in most eukaryotes by protecting cohesion at the centromere until the
Externí odkaz:
https://doaj.org/article/71fd532efbd2418d8b8d9ba43b80cc4d
Autor:
Nuria Ferrandiz, Consuelo Barroso, Oana Telecan, Nan Shao, Hyun-Min Kim, Sarah Testori, Peter Faull, Pedro Cutillas, Ambrosius P. Snijders, Monica P. Colaiácovo, Enrique Martinez-Perez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
During meiosis, step-wise release of sister chromatid cohesion mediated by REC-8 cohesin is required for the formation of haploid gametes. Here, the authors show that in C. elegans oocytes, regulated recruitment of Aurora B kinase ensures the correct
Externí odkaz:
https://doaj.org/article/a5f72f87d8f44fc2a699bfa24b78e92b
Autor:
Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo
Publikováno v:
eLife, Vol 5 (2016)
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog
Externí odkaz:
https://doaj.org/article/4df71421871c44c4a4879464b70529bc
Autor:
Oliver Crawley, Consuelo Barroso, Sarah Testori, Nuria Ferrandiz, Nicola Silva, Maikel Castellano-Pozo, Angel Luis Jaso-Tamame, Enrique Martinez-Perez
Publikováno v:
eLife, Vol 5 (2016)
Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure. Cohesin complexes containing meiosis-specific kleisin subunits govern most aspects of meiotic chr
Externí odkaz:
https://doaj.org/article/4b4e7c5ddc494e91840a5f486dd22405
Autor:
Nuria Ferrandiz, Consuelo Barroso, Oana Telecan, Nan Shao, Hyun-Min Kim, Sarah Testori, Peter Faull, Pedro Cutillas, Ambrosius P. Snijders, Monica P. Colaiácovo, Enrique Martinez-Perez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the spelling of the author Ambrosius P. Snijders, which was incorrectly given as Ambrosious P. Snijders. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/0280652110904512bb6f477a7fc37991