Výsledky vyhledávání - "Enrique Martinez-Perez"

Akademický článek

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

Autor: Maikel Castellano-Pozo, Georgios Sioutas, Consuelo Barroso, Josh P Prince, Pablo Lopez-Jimenez, Joseph Davy, Angel-Luis Jaso-Tamame, Oliver Crawley, Nan Shao, Jesus Page, Enrique Martinez-Perez

Publikováno v: eLife, Vol 12 (2023)

The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesi

Externí odkaz: https://doaj.org/article/1235e182b1454f73a8f6a72952cf9905

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Akademický článek

GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.

Autor: Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo

Publikováno v: PLoS Genetics, Vol 19, Iss 2, p e1010666 (2023)

Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1,

Externí odkaz: https://doaj.org/article/256d8d7b5f334b59810c1d4d8aae4a05

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Akademický článek

Cohesin is required for meiotic spindle assembly independent of its role in cohesion in C. elegans.

Autor: Karen P McNally, Elizabeth A Beath, Brennan M Danlasky, Consuelo Barroso, Ting Gong, Wenzhe Li, Enrique Martinez-Perez, Francis J McNally

Publikováno v: PLoS Genetics, Vol 18, Iss 10, p e1010136 (2022)

Accurate chromosome segregation requires a cohesin-mediated physical attachment between chromosomes that are to be segregated apart, and a bipolar spindle with microtubule plus ends emanating from exactly two poles toward the paired chromosomes. We a

Externí odkaz: https://doaj.org/article/8a80bd3aaa3e4fb3bcc091f424568ecf

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Akademický článek

Surveillance of cohesin-supported chromosome structure controls meiotic progression

Autor: Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H. Dore, Mohammad M. Karimi, Enrique Martinez-Perez

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a m

Externí odkaz: https://doaj.org/article/ca7beece05774737bac58f1c2cc21c92

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Akademický článek

Proline-specific aminopeptidase P prevents replication-associated genome instability.

Autor: Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1010025 (2022)

Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular

Externí odkaz: https://doaj.org/article/a96ac9391b0141f5855e9de298dde95f

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Akademický článek

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.

Autor: Aya Sato-Carlton, Chihiro Nakamura-Tabuchi, Xuan Li, Hendrik Boog, Madison K Lehmer, Scott C Rosenberg, Consuelo Barroso, Enrique Martinez-Perez, Kevin D Corbett, Peter Mark Carlton

Publikováno v: PLoS Genetics, Vol 16, Iss 11, p e1008968 (2020)

In the two cell divisions of meiosis, diploid genomes are reduced into complementary haploid sets through the discrete, two-step removal of chromosome cohesion, a task carried out in most eukaryotes by protecting cohesion at the centromere until the

Externí odkaz: https://doaj.org/article/71fd532efbd2418d8b8d9ba43b80cc4d

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Akademický článek

Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis

Autor: Nuria Ferrandiz, Consuelo Barroso, Oana Telecan, Nan Shao, Hyun-Min Kim, Sarah Testori, Peter Faull, Pedro Cutillas, Ambrosius P. Snijders, Monica P. Colaiácovo, Enrique Martinez-Perez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

During meiosis, step-wise release of sister chromatid cohesion mediated by REC-8 cohesin is required for the formation of haploid gametes. Here, the authors show that in C. elegans oocytes, regulated recruitment of Aurora B kinase ensures the correct

Externí odkaz: https://doaj.org/article/a5f72f87d8f44fc2a699bfa24b78e92b

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