Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Enrique M, Toledo"'
Autor:
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new
Externí odkaz:
https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677
Autor:
Florian Klimm, Enrique M. Toledo, Thomas Monfeuga, Fang Zhang, Charlotte M. Deane, Gesine Reinert
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Recent advances in single-cell RNA sequencing have allowed researchers to explore transcriptional function at a cellular level. In particular, single-cell RNA sequencing reveals that there exist clusters of cells with similar gene
Externí odkaz:
https://doaj.org/article/1dac96c804a549c589fad5752cff1859
Autor:
Malgorzata Cyranka, Thomas Monfeuga, Natascia Vedovato, Chelsea M Larabee, Anandhakumar Chandran, Enrique M Toledo, Heidi de Wet
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Type 2 diabetes mellitus (T2DM) remains one of the most pressing health issues facing modern society. Several antidiabetic drugs are currently in clinical use to treat hyperglycaemia, but there is a need for new treatments that effectively restore pa
Externí odkaz:
https://doaj.org/article/c8783ab345114d4cb005c6e2be4c48d4
Autor:
Maqsood Ahmed, Matthew J. S. Owens, Enrique M. Toledo, Ernest Arenas, Mark Bradley, Charles ffrench-Constant
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The development of efficient cell culture strategies for the generation of dopaminergic neurons is an important goal for transplantation-based approaches to treat Parkinson’s disease. To identify extracellular matrix molecules that enhance differen
Externí odkaz:
https://doaj.org/article/d8b2ce2e332846668d6af68faa4ae1e6
Autor:
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552- (2021)
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In
Externí odkaz:
https://doaj.org/article/0fd0f2e5fb724e438758d7df1a29d1bc
Autor:
Enrique M. Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E. van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L. Grigsby, Peter Lönnerberg, Saiful Islam, Knut R. Steffensen, Sten Linnarsson, Ernest Arenas
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Liver X receptors (LXRs) and their ligands are potent regulators of midbrain dopaminergic (mDA) neurogenesis and differentiation. However, the molecular mechanisms by which LXRs control these functions remain to be elucidated. Here, we perfo
Externí odkaz:
https://doaj.org/article/f4229bb19bc34ba8985a4bcb466ddeea
Autor:
Daniel Gyllborg, Maqsood Ahmed, Enrique M. Toledo, Spyridon Theofilopoulos, Shanzheng Yang, Charles ffrench-Constant, Ernest Arenas
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 651-664 (2018)
Summary: The development of midbrain dopaminergic (mDA) neurons is controlled by multiple morphogens and transcription factors. However, little is known about the role of extracellular matrix proteins in this process. Here we examined the function of
Externí odkaz:
https://doaj.org/article/e89eae21d5a5462ba937e9ed8c10d164
Autor:
Satoshi Okawa, Carmen Saltó, Srikanth Ravichandran, Shanzheng Yang, Enrique M. Toledo, Ernest Arenas, Antonio del Sol
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Gaining insight into cell identities from single cell RNA-seq data remains a challenge. Here, the authors introduce an approach to identify transcription factors (TFs) that synergistically determine cellular identities, and demonstrate its ability to
Externí odkaz:
https://doaj.org/article/1b7c6baab5e84bcfa07a16f64922ceec
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 39-44 (2006)
Prion diseases are fatal neurodegenerative disorders associated with the conversion of the cellular prion protein (PrPC) into a pathologic isoform. Although the physiological function of PrPC remains unknown, evidence relates PrPC to copper metabolis
Externí odkaz:
https://doaj.org/article/4ea79e098f4a4831b05d34696ac89af5
Autor:
Himjyot Jaiswal, Philip J. Starkey Lewis, Carl S. Tucker, James W. Dear, Joanna Simpson, Jeremy Hughes, Oliver Flint, Sofia Ferreira-Gonzalez, Baltasar Lucendo-Villarin, Natalie Z.M. Homer, Esther Mellado-Gomez, Stuart J. Forbes, Enrique M. Toledo, Allan E. Karlsen, Nicola L. Beer, Jose Meseguer-Ripolles, David C. Hay, Yu Wang
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552-(2021)
iScience
Meseguer Ripolles, J, Lucendo Villarin, B, Tucker, C, Ferreira-Gonzalez, S, Homer, N Z M, Wang, Y, Starkey Lewis, P, Toledo Maldonado, E, Mellado-Gomez, E, Simpson, J, Flint, O, Jaiswal, H, Beer, N L, Karlsen, A E, Forbes, S J, Dear, J W, Hughes, J & Hay, D C 2021, ' Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure ', iScience . https://doi.org/10.1016/j.isci.2021.102552
iScience
Meseguer Ripolles, J, Lucendo Villarin, B, Tucker, C, Ferreira-Gonzalez, S, Homer, N Z M, Wang, Y, Starkey Lewis, P, Toledo Maldonado, E, Mellado-Gomez, E, Simpson, J, Flint, O, Jaiswal, H, Beer, N L, Karlsen, A E, Forbes, S J, Dear, J W, Hughes, J & Hay, D C 2021, ' Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure ', iScience . https://doi.org/10.1016/j.isci.2021.102552
Summary Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In t