Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Enrique Alvarez-Manzaneda"'
Autor:
Houda Zentar, Fatin Jannus, Marta Medina-O’Donnell, Az-eddine El Mansouri, Antonio Fernández, José Justicia, Enrique Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Rachid Chahboun
Publikováno v:
Molecules, Vol 28, Iss 17, p 6208 (2023)
Pterolobirin H (3), a cassane diterpene isolated from the roots of Pterolobium macropterum, exhibits important anti-inflammatory and anticancer properties. However, its relatively complex tetracyclic structure makes it difficult to obtain by chemical
Externí odkaz:
https://doaj.org/article/c948a183fadb45788d80e3bc367ad5cf
Autor:
Juan J. Guardia, Antonio Fernández, José Justicia, Houda Zentar, Ramón Alvarez-Manzaneda, Enrique Alvarez-Manzaneda, Rachid Chahboun
Publikováno v:
Molecules, Vol 28, Iss 4, p 1524 (2023)
The acid treatment of 6,7-seco-abietane dialdehydes gives, in high yield, the corresponding derivatives with the 4a-methyltetrahydrofluorene skeleton of taiwaniaquinoids. A mechanism involving the elimination of formic acid from the cyclic aldol inte
Externí odkaz:
https://doaj.org/article/94d10ff90a954fa2a551af27cdf0539e
Autor:
Houda Zentar, Fatin Jannus, Marta Medina-O’Donnell, José A. Lupiáñez, José Justicia, Ramón Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Enrique Alvarez-Manzaneda, Rachid Chahboun
Publikováno v:
Molecules, Vol 27, Iss 17, p 5705 (2022)
A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopol
Externí odkaz:
https://doaj.org/article/ecebf23647de40cd91d6145d6ccafff0
Autor:
Inmaculada Ramírez-Macías, Clotilde Marín, Rachid Chahboun, Francisco Olmo, Ibtisam Messouri, Oscar Huertas, María Jose Rosales, Ramón Gutierrez-Sánchez, Enrique Alvarez-Manzaneda, Manuel Sánchez-Moreno
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 3, Pp 370-376 (2012)
The activity of five (1-5) abietane phenol derivatives against Leishmania infantum and Leishmania braziliensis was studied using promastigotes and axenic and intracellular amastigotes. Infectivity and cytotoxicity tests were performed with J774.2 mac
Externí odkaz:
https://doaj.org/article/fed7a2c0a4d84f8791e85dad6bc24bf4
Autor:
Houda Zentar, Fatin Jannus, Pilar Gutierrez, Marta Medina-O’Donnell, José Antonio Lupiáñez, Fernando J. Reyes-Zurita, Enrique Alvarez-Manzaneda, Rachid Chahboun
Publikováno v:
Journal of natural products. 85(10)
A new strategy for the semisynthesis of the aromatic cassane-type diterpene taepeenin F (6) is reported. The introduction of the methyl group at C-14, characteristic of the target compound, was achieved via dienone 13, easily prepared from abietic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a3ac22f6323e6881d04b5a159baf00
https://pubmed.ncbi.nlm.nih.gov/36215157
https://pubmed.ncbi.nlm.nih.gov/36215157
Autor:
Houda Zentar, Fatin Jannus, Marta Medina-O’Donnell, José A. Lupiáñez, José Justicia, Ramón Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Enrique Alvarez-Manzaneda, Rachid Chahboun
Publikováno v:
Molecules; Volume 27; Issue 17; Pages: 5705
riUAL. Repositorio Institucional de la Universidad de Almería
Universidad de Almería
riUAL. Repositorio Institucional de la Universidad de Almería
Universidad de Almería
A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e0debd8f39e09894526a49ecccee0d
https://hdl.handle.net/10481/77050
https://hdl.handle.net/10481/77050
Autor:
Rachid Chahboun, Fermín Jiménez, María Jesús Durán-Peña, Enrique Alvarez-Manzaneda, Ramón Alvarez-Manzaneda, José Manuel Botubol-Ares
Publikováno v:
The Journal of organic chemistry. 86(13)
A general and efficient method for the deconjugative α-alkylation of α,β-unsaturated aldehydes promoted by a synergistic effect between tBuOK and NaH, which considerably increases the reaction rate under mild conditions, is reported. The β,γ-uns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d716e58f56fc7f688cf1690c3edf3a
https://pubmed.ncbi.nlm.nih.gov/34128666
https://pubmed.ncbi.nlm.nih.gov/34128666
Autor:
Juan J. Guardia, Manuel Sánchez-Moreno, Rubén Martín-Escolano, Javier Martín-Escolano, Antonio Fernandez, Clotilde Marín, Rachid Chahboun, Nuria Cirauqui, Enrique Alvarez-Manzaneda, María José Rosales
Publikováno v:
Journal of natural products. 83(12)
The life-long and life-threatening Chagas disease is one of the most neglected tropical diseases caused by the protozoan parasite Trypanosoma cruzi. It is a major public health problem in Latin America, as six to seven million people are infected, be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec99d81a6932045d966a2798a6eaf6f
https://pubmed.ncbi.nlm.nih.gov/33253573
https://pubmed.ncbi.nlm.nih.gov/33253573
Publikováno v:
The Journal of organic chemistry. 85(5)
The first synthesis of the marine benzoxepane hydroquinone cyclosiphonodictyol A and its bis(sulfato) from commercial (+)-sclareolide is reported. The key steps of the synthetic sequence (11 steps, 46% global) are the nucleophilic attack of a hindere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf90772f712ad28e3b4ec4c6f1c0973
https://pubmed.ncbi.nlm.nih.gov/32026692
https://pubmed.ncbi.nlm.nih.gov/32026692
Autor:
Houda Zentar, Ali Haidour, Ramón Alvarez-Manzaneda, Fabio Arias, Rachid Chahboun, Enrique Alvarez-Manzaneda
Publikováno v:
Organic Letters. 20:7007-7010
An expeditious route to obtaining cassane-type furan diterpenes starting from (+)-sclareolide, an inexpensive commercially available natural lactone, has been achieved by using a solvent-free Diels-Alder cycloaddition and an unprecedented decarboxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be5a09ba95529c61b17387c91c94206
https://doi.org/10.1021/acs.orglett.8b02867
https://doi.org/10.1021/acs.orglett.8b02867