VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry

Autor: Daniel Delgado-Bellido, Esteban Zamudio-Martínez, Mónica Fernández-Cortés, Ana Belén Herrera-Campos, Joaquin Olmedo-Pelayo, Carmen Jordán Perez, José Expósito, Enrique de Álava, Ana Teresa Amaral, Francisco O’ Valle, Angel Garcia Diaz, F. J. Oliver

Publikováno v: Cell Death and Disease, Vol 14, Iss 2, Pp 1-11 (2023)

Abstract Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment f

Externí odkaz: https://doaj.org/article/4b08f40ad789471d99691db03f23e4ae

Sarcoma classification by DNA methylation profiling

Autor: Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, Andreas von Deimling

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve c

Externí odkaz: https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b

Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials

Autor: Lourdes Hontecillas-Prieto, Rocío Flores-Campos, Andrew Silver, Enrique de Álava, Nabil Hajji, Daniel J. García-Domínguez

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated toxicity due to the non-tumor-associated effects, development of secondary malignancies, infertility, radiation-induced fibrosi

Externí odkaz: https://doaj.org/article/88fdb04d55f0452cbdb1d32c6a26a0c4

Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation

Autor: Marta Espinosa, Juan Maria Roldán-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo, Cristina Rodriguez-Antona

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-5 (2018)

Abstract Background Renal epithelioid angiomyolipomas (EAML) are rare tumors with aggressive behavior. EAML can be sporadic or develop within the tuberous sclerosis complex syndrome, where mutations of TSC1 or TSC2 genes (critical negative regulators

Externí odkaz: https://doaj.org/article/2bd539ec21a8436dba069747c6d59b14

Supplementary Information from Preclinical Efficacy of Endoglin-Targeting Antibody–Drug Conjugates for the Treatment of Ewing Sarcoma

Autor: Enrique de Álava, Joseph A. Ludwig, Ángel M. Carcaboso, Myriam Fabre, Laureano Simón, Klaus Pfizenmaier, Roland Kontermann, Oliver Seifert, Keri Schadler, Branko Cuglievan, Jaume Mora, Cristina Ferrer, Michele Biscuola, María José Robles-Frías, Gema Civantos-Jubera, Maria Lopez-Alvarez, Laura Romero-Pérez, Juan Diaz-Martin, Carmen Jordan-Perez, Saioa Domínguez, José Luis Ordóñez, Helena Castillo-Ecija, Brian A. Menegaz, Salah-Eddine Lamhamedi-Cherradi, Ana Teresa Amaral, Pilar Puerto-Camacho

Supplementary Material & Methods, Figure Legends and Tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd417750e3901010bac209354fb6511
https://doi.org/10.1158/1078-0432.22472516