Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://doaj.org/article/facd8b78a4874d8e865b236e82696fcb

Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: A comparative study with 17β-estradiol

Autor: Germán Torregrosa, Enrique Alborch, María Jorques, Salvador Pérez, Alicia Aliena-Valero, María C. Burguete, José M. Centeno, Francisco J. Miranda, Andrés Jurado-Rodríguez, Juan B. Salom, Mikahela A. López-Morales, María Castelló-Ruiz, Teresa Jover-Mengual

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

As the knowledge on the estrogenic system in the brain grows, the possibilities to modulate it in order to afford further neuroprotection in brain damaging disorders so do it. We have previously demonstrated the ability of the selective estrogen rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b256523154b3a7988cfc97f63cef7a4
https://doi.org/10.1016/j.jsbmb.2017.05.001

Relaxant Effects of the Selective Estrogen Receptor Modulator, Bazedoxifene, and Estrogen Receptor Agonists in Isolated Rabbit Basilar Artery

Autor: Alessandro Arduini, María C. Burguete, Germán Torregrosa, Mikahela A. López-Morales, Juan B. Salom, Teresa Jover-Mengual, Enrique Alborch, María Castelló-Ruiz, David Hervás, Ricardo Fernández-Musoles

Publikováno v: Journal of Cardiovascular Pharmacology. 68:313-321

We have previously shown that the selective estrogen receptor modulator, bazedoxifene, improves the consequences of ischemic stroke. Now we aimed to characterize the effects and mechanisms of action of bazedoxifene in cerebral arteries. Male rabbit i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657fd29dba2b1d39ef6f411661abf6ea
https://doi.org/10.1097/fjc.0000000000000418

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Juan B. Salom, Enrique Alborch, Teresa Gasull, Isaac García-Yébenes, Pedro Ramos-Cabrer, Ignacio Lizasoain, María Castelló-Ruiz, Jovita Ponce, Verónica Guirao, Mónica Millán, José Castillo, Antoni Dávalos, Octavi Martí-Sistac, Nuria DeGregorio-Rocasolano

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Redox Biology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810b789a7d186b24d714a1ffbfc93687
https://ddd.uab.cat/record/190741

Mechanisms involved in the increased sensitivity of the rabbit basilar artery to atrial natriuretic peptide in diabetes

Autor: Germán Torregrosa, Alicia Aliena-Valero, Francisco J. Miranda, Enrique Alborch, Juan B. Salom, María Castelló-Ruiz, María C. Burguete, José M. Centeno, Vannina G. Marrachelli, Mikahela A. López-Morales, Teresa Jover-Mengual

Publikováno v: EUROPEAN JOURNAL OF PHARMACOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Atrial natriuretic peptide (ANP) is a vasodilator with significant regional differences and controversial effects in the cerebral circulation, a vascular bed particularly prone to diabetes-induced complications. The present study has investigated how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69796bb25b6a0b5df720e52d31ff25a3
https://pubmed.ncbi.nlm.nih.gov/29024691