Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Enrico Zanforlin"'
Autor:
Alexander O. Terent'ev, Ivan A. Yaremenko, Peter S. Radulov, Yulia Yu. Belyakova, Yuan-Qing Qu, Vincent Kam Wai Wong, Congling Qiu, Vladimir A. Kokorekin, Parichat Prommana, Chairat Uthaipibull, Paolo Coghi, Enrico Zanforlin, Fabrice Fleury, Yuki Yu Jun Wu
Publikováno v:
ChemMedChem. 15(13)
This article discloses a new horizon for the application of peroxides in medical chemistry. Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in addition a mechanism of cytotoxic action is proposed. Synthetic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9696dbb69845ad3c6726dacb38c3790
https://pubmed.ncbi.nlm.nih.gov/32154637
https://pubmed.ncbi.nlm.nih.gov/32154637
Autor:
Roberto Battistutta, Giovanni Ribaudo, Stefania Sarno, Andrea Dalle Vedove, Giuseppe Zagotto, Francesca Zonta, Graziano Lolli, Nicola Demitri, Alberto Ongaro, Maria Ruzzene, Giulia Cazzanelli, Enrico Zanforlin
Protein kinase CK2 sustains cancer growth, especially in hematological malignancies. Its inhibitor SRPIN803, based on a 6-methylene-5-imino-1,3,4-thiadiazolopyrimidin-7-one scaffold, showed notable specificity. Our synthesis of the initially proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37891d16707635691d74728a3c95264b
http://hdl.handle.net/11572/275324
http://hdl.handle.net/11572/275324
Publikováno v:
ACS Chemical Neuroscience. 8:2356-2368
Among the diseases affecting the central nervous system (CNS), neurodegenerations attract the interest of both the clinician and the medicinal chemist. The increasing average age of population, the growing number of patients, and the lack of long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f86bf8f0ff589d546e3ba6c3e1f42e
https://doi.org/10.1021/acschemneuro.7b00283
https://doi.org/10.1021/acschemneuro.7b00283
Autor:
Giovanni Ribaudo, Giuseppe Zagotto, Yu Han, Yuan Qing Qu, Alena Congling Qiu, Yuki Yu Jun Wu, Vincent Kam Wai Wong, Paolo Coghi, Betty Yuen Kwan Law, Enrico Zanforlin
BACE-1 is considered to be one of the targets for prevention and treatment of Alzheimer's disease (AD). We here report a novel class of semi-synthetic derivatives of prenylated isoflavones, obtained from the derivatization of natural flavonoids from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcb01b1685bf3256ef6e13c71551610
http://hdl.handle.net/11577/3311824
http://hdl.handle.net/11577/3311824
Background: The possibilities of treatment for oncological diseases are growing enormously in the last decades. Unfortunately, these developments have led to the onset of resistances with regards to the new treatments. This is particularly true if we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a43b9ab60aadd6e717b6c685158130
http://hdl.handle.net/11577/3336712
http://hdl.handle.net/11577/3336712
Autor:
Vincent Kam Wai Wong, Enrico Zanforlin, Ivan A. Yaremenko, Congling Qiu, Vladimir A. Kokorekin, Parichat Prommana, Fabrice Fleury, Chairat Uthaipibull, Peter S. Radulov, Yulia Yu. Belyakova, Yuan-Qing Qu, Alexander O. Terent'ev, Paolo Coghi, Yuki Yu Jun Wu
Publikováno v:
ChemMedChem. 15:1101-1101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf161a683a2c65039ccf862aa383b86
https://doi.org/10.1002/cmdc.202000413
https://doi.org/10.1002/cmdc.202000413
The introduction of tyrosine kinase inhibitors (TKIs) in the clinical management of oncological patients spread the light on the use of selective, rationally designed small molecules for the treatment of cancer. First-generation TKIs bared high respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2f2b02cee56f2fe967e9308a7b6b4b
http://hdl.handle.net/11379/518384
http://hdl.handle.net/11379/518384
Publikováno v:
Current medicinal chemistry. 24(34)
Background Dementias and all related neurodegenerative diseases of the Central Nervous System (CNS) are a current issue arousing a great deal of interest in the international scientific community. This is due to the increasing number of patients suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a77060f2a66d115ea1ab4104f8a64f
https://pubmed.ncbi.nlm.nih.gov/28707586
https://pubmed.ncbi.nlm.nih.gov/28707586
Parkinson’s disease (PD) is a neurodegenerative disorder bearing motor and nonmotor symptoms. The treatment today is symptomatical rather than preventive or curative and this leaves the field open for the search of both novel molecular targets and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19186d65e9d944aeff8de0a5628d7a52