Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Enrico Petretto"'
Autor:
Gabriel Chew, Aaron Shengting Mai, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, Eng-King Tan
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic signatures can provide novel gene candidates for use as PD biomarkers. We leveraged on
Externí odkaz:
https://doaj.org/article/9ff9d1d7fa4f4d8294c483c3b3fdaab4
Autor:
Jiatong Ji, Honglu Chao, Huimei Chen, Jun Liao, Wenqian Shi, Yangfan Ye, Tian Wang, Yongping You, Ning Liu, Jing Ji, Enrico Petretto
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Frontotemporal lobe abnormalities are linked to neuropsychiatric disorders and cognition, but the role of cellular heterogeneity between temporal lobe (TL) and frontal lobe (FL) in the vulnerability to genetic risk factors remains to be elucidated. W
Externí odkaz:
https://doaj.org/article/6d22fdbc73134266a33a9f846ab96637
Autor:
Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105127- (2024)
Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l
Externí odkaz:
https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432
Autor:
Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli, Millie Seow, Jing Guo, Zuhua Cai, Sze Jie Loo, Eric Lim, Ru San Tan, Elina Grishina, Poh Loong Soong, Narayan Lath, Lei Ye, Enrico Petretto, Karl Tryggvason
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Ischemic heart disease, which is often associated with irreversibly damaged heart muscle, is a major global health burden. Here, we report the potential of stem cell-derived committed cardiac progenitors (CCPs) have in regenerative cardiolog
Externí odkaz:
https://doaj.org/article/efda7fe383264fd9a71daf9a83a77ec1
Autor:
Yi Xie, Huimei Chen, Vasuki Ranjani Chellamuthu, Ahmad bin Mohamed Lajam, Salvatore Albani, Andrea Hsiu Ling Low, Enrico Petretto, Jacques Behmoaras
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3828 (2024)
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique for investigating biological heterogeneity at the single-cell level in human systems and model organisms. Recent advances in scRNA-seq have enabled the pooling of cells from m
Externí odkaz:
https://doaj.org/article/bec439f169424ea680043f137d3c61d2
Autor:
John F Ouyang, Kunal Mishra, Yi Xie, Harry Park, Kevin Y Huang, Enrico Petretto, Jacques Behmoaras
Publikováno v:
eLife, Vol 12 (2023)
Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis. The recently unravelled multi-organ heterogeneity of macrophages in healthy
Externí odkaz:
https://doaj.org/article/dfb5459357644fef94bd525a0a0ecfd8
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Repair processes in kidney are impaired in severe disease. Here, the authors show that in kidney failure, genetic or pharmacologic inhibition of IL11 releases the brake on regeneration, reverses tissue damage and restores kidney function.
Externí odkaz:
https://doaj.org/article/60e0f4d907fc4280bc1f88c1b900af64
Autor:
Huimei Chen, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Kevin Y. Huang, Jing Guo, Shiyang Liu, Elisabeth Li Sa Tan, Shuang Chen, Nicole Gui Zhen Tee, Masum M. Mia, Manvendra K. Singh, Aihua Zhang, Jacques Behmoaras, Enrico Petretto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocy
Externí odkaz:
https://doaj.org/article/04ab9cd1a1a34c4da30eb9e5180335f7
Autor:
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondria
Externí odkaz:
https://doaj.org/article/27de688eb5a24929b14771a4cd8acfce
Autor:
Catherine M. Francis, Matthias E. Futschik, Jian Huang, Wenjia Bai, Muralidharan Sargurupremraj, Alexander Teumer, Monique M. B. Breteler, Enrico Petretto, Amanda S. R. Ho, Philippe Amouyel, Stefan T. Engelter, Robin Bülow, Uwe Völker, Henry Völzke, Marcus Dörr, Mohammed-Aslam Imtiaz, N. Ahmad Aziz, Valerie Lohner, James S. Ware, Stephanie Debette, Paul Elliott, Abbas Dehghan, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Aortic distensibility is a risk factor for multiple cardiovascular events, but the genetic etiology is not well understood. Here, the authors identify genetic variants linked to aortic distensibility, highlighting mechanistic pathways and causal rela
Externí odkaz:
https://doaj.org/article/a5d0caf9381c40529e225078de909c70