Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Enrico Mombelli"'
Autor:
Guillaume Ollitrault, Marco Marzo, Alessandra Roncaglioni, Emilio Benfenati, Enrico Mombelli, Olivier Taboureau
Publikováno v:
Toxics, Vol 12, Iss 8, p 541 (2024)
Endocrine-disrupting chemicals (EDCs) are chemicals that can interfere with homeostatic processes. They are a major concern for public health, and they can cause adverse long-term effects such as cancer, intellectual impairment, obesity, diabetes, an
Externí odkaz:
https://doaj.org/article/ee158f8449a14ed79360e4daea097c70
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2425
Information on genotoxicity is an essential piece of information in the framework of several regulations aimed at evaluating chemical toxicity. In this context, QSAR models that can predict Ames genotoxicity can conveniently provide relevant informat
Autor:
Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
Publikováno v:
Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79
Read-across approaches often remain inconclusive as they do not provide sufficient evidence on a common mode of action across the category members. This read-across case study on thirteen, structurally similar, branched aliphatic carboxylic acids inv
Autor:
Gladys Ouedraogo, Camilla Alexander-White, Dagmar Bury, Harvey J. Clewell, Mark Cronin, Tom Cull, Matthew Dent, Bertrand Desprez, Ann Detroyer, Corie Ellison, Stefania Giammanco, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Martina Klaric, Reinhard Kreiling, Cathy Lester, Catherine Mahony, Enrico Mombelli, Jorge Naciff, John O'Brien, Andreas Schepky, Sarah Tozer, Bart van der Burg, Barbara van Vugt-Lussenburg, Sharon Stuard, null Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 132
Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates
Publikováno v:
Molecular Informatics
Molecular Informatics, Wiley-VCH, 2020, 39, pp.art. 2000072. ⟨10.1002/minf.202000072⟩
Molecular Informatics, Wiley-VCH, 2020, 39, pp.art. 2000072. ⟨10.1002/minf.202000072⟩
The adipose tissue:blood partition coefficient is a key‐endpoint to predict the pharmacokinetics of chemicals in humans and animals, since other organ:blood affinities can be estimated as a function of this parameter. We performed a search in the l
Autor:
Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (
Publikováno v:
Toxicology Letters. 350:S87
Autor:
Enrico Mombelli, Pascal Pandard
Publikováno v:
Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology, Elsevier, 2021, 122, pp.104893. ⟨10.1016/j.yrtph.2021.104893⟩
Regulatory Toxicology and Pharmacology, Elsevier, 2021, 122, pp.104893. ⟨10.1016/j.yrtph.2021.104893⟩
International audience; Regulatory frameworks require information on acute fish toxicity to ensure environmental protection. The experimental assessment of this property relies on a substantial number of fish to be tested and it is in conflict with t
Autor:
Enrico Mombelli, Alessandra Roncaglioni, Cosimo Toma, Serena Manganelli, Domenico Gadaleta, Emilio Benfenati
Publikováno v:
Journal of Chemical Information and Modeling
Nonalcoholic hepatic steatosis is a worldwide epidemiological concern since it is among the most prominent hepatic diseases. Indeed, research in toxicology and epidemiology has gathered evidence that exposure to endocrine disruptors can perturb cellu
Publikováno v:
96. Congrès de l'ASTEE "Des territoires à l’Europe : Construire ensemble les transitions environnementales"
96. Congrès de l'ASTEE "Des territoires à l’Europe : Construire ensemble les transitions environnementales", Jun 2017, Liège, Belgique
Salon Aquaterritorial
Salon Aquaterritorial, Sep 2016, Mulhouse, France
HAL
96. Congrès de l'ASTEE "Des territoires à l’Europe : Construire ensemble les transitions environnementales", Jun 2017, Liège, Belgique
Salon Aquaterritorial
Salon Aquaterritorial, Sep 2016, Mulhouse, France
HAL
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::48b2d6249b30faebaf85f724640a7975
https://hal-ineris.archives-ouvertes.fr/ineris-01853105
https://hal-ineris.archives-ouvertes.fr/ineris-01853105