Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Enrico Maria, Silini"'
Autor:
Melissa Bersanelli, Letizia Gnetti, Francesco Paolo Pilato, Elena Varotti, Federico Quaini, Nicoletta Campanini, Elena Rapacchi, Roberta Camisa, Paolo Carbognani, Enrico Maria Silini, Michele Rusca, Francesco Leonardi, Umberto Maestroni, Mimma Rizzo, Matteo Brunelli, Sebastiano Buti, Luca Ampollini
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 743-756 (2023)
Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistance. This study aimed to assess the inter-tumoral, intra
Externí odkaz:
https://doaj.org/article/e9629c4493ad4954bcecdc2c4c5fa8ce
Autor:
Benedetta Pellegrino, Luisa Carbognin, Emilio Bria, Alberto Zambelli, Filippo Montemurro, Elena Fiorio, Claudio Zamagni, Nicoletta Campanini, Michele Tognetto, Gabriele Missale, Antonino Musolino, Stefania Gori, Giuseppe Maglietta, Chiara Tommasi, Olga Serra, Elisabetta Cretella, Massimo Ambroggi, Antonio Frassoldati, Giancarlo Bisagni, Chiara Casarini, Antonella Mura, Lorenzo Gianni, Renata Todeschini, Enrico Maria Silini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background It is possible to induce immunomodulation in HER2-positive breast cancer (BC) by modifying the route of administration of trastuzumab.Methods In this multicenter randomized phase II trial, all enrolled patients (pts) with T2–T4d HER2-pos
Externí odkaz:
https://doaj.org/article/cb245d7c7a6b4364ba2d9bf6da750467
Autor:
Elisa Callegari, Paola Guerriero, Cristian Bassi, Lucilla D’Abundo, Antonio Frassoldati, Edi Simoni, Laura Astolfi, Enrico Maria Silini, Silvia Sabbioni, Massimo Negrini
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 538-549 (2022)
Palbociclib is in early-stage clinical testing in advanced hepatocellular carcinoma (HCC). Here, we investigated whether the anti-tumor activity of palbociclib, which prevents the CDK4/6-mediated phosphorylation of RB1 but simultaneously activates AK
Externí odkaz:
https://doaj.org/article/701879adeaa542da8665c540f3d200b5
Autor:
Donatello Gasparro, Maura Scarlattei, Enrico Maria Silini, Silvia Migliari, Giorgio Baldari, Veronica Cervati, Tiziano Graziani, Nicoletta Campanini, Umberto Maestroni, Livia Ruffini
Publikováno v:
Diagnostics, Vol 13, Iss 19, p 3082 (2023)
In oligo-metastatic renal cell carcinoma (RCC), neither computed tomography (CT) nor bone scan is sensitive enough to detect small tumor deposits hampering early treatment and potential cure. Prostate-specific membrane antigen (PSMA) is a transmembra
Externí odkaz:
https://doaj.org/article/99ef8173030e4625a19ee8e4e94461ba
Autor:
Francesca Negri, Lorena Bottarelli, Giuseppe Pedrazzi, Michele Maddalo, Ludovica Leo, Gianluca Milanese, Roberto Sala, Michele Lecchini, Nicoletta Campanini, Cecilia Bozzetti, Andrea Zavani, Gianluca Di Rienzo, Cinzia Azzoni, Enrico Maria Silini, Nicola Sverzellati, Federica Gaiani, Gian Luigi de’ Angelis, Letizia Gnetti
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe Notch intracellular domain (NICD) and its ligands Jagged-1(Jag1), Delta-like ligand (DLL-3) and DLL4 play an important role in neoangiogenesis. Previous studies suggest a correlation between the tissue levels of NICD and response to t
Externí odkaz:
https://doaj.org/article/7b444c4b7221495b890416abc0bc4077
Autor:
Giulia Mazzaschi, Alessandro Lazzarin, Matteo Santoni, Francesca Trentini, Ugo De Giorgi, Nicole Brighi, Chiara Tommasi, Silvia Puglisi, Orazio Caffo, Stefania Kinspergher, Alessia Mennitto, Carlo Cattrini, Elena Verzoni, Alessandro Rametta, Marco Stellato, Andrea Malgeri, Giandomenico Roviello, Enrico Maria Silini, Pasquale Rescigno, Sara Elena Rebuzzi, Giuseppe Fornarini, Federico Quaini, Giulia Claire Giudice, Giuseppe Luigi Banna, Sebastiano Buti
Publikováno v:
Frontiers in Bioscience-Elite, Vol 15, Iss 3, p 20 (2023)
Background: The advent of immune checkpoint inhibitors (ICIs) has revolutionized the metastatic renal cell carcinoma (mRCC) therapeutic landscape. Nevertheless, tyrosine-kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF)
Externí odkaz:
https://doaj.org/article/922e18e923f6408ebcb291c324656551
Autor:
Elisa Callegari, Marco Domenicali, Ram Charan Shankaraiah, Lucilla D’Abundo, Paola Guerriero, Ferdinando Giannone, Maurizio Baldassarre, Cristian Bassi, Bahaeldin K. Elamin, Barbara Zagatti, Manuela Ferracin, Francesca Fornari, Giuseppe Altavilla, Stella Blandamura, Enrico Maria Silini, Laura Gramantieri, Silvia Sabbioni, Massimo Negrini
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 239-250 (2019)
Most hepatocellular carcinomas (HCCs) arise in the context of chronic liver disease and/or cirrhosis. Thus, chemoprevention in individuals at risk represents an important but yet unproven approach. In this study, we investigated the ability of microR
Externí odkaz:
https://doaj.org/article/4e08f8cbe4744a7dbc6758c90aa58e46
Autor:
Marcello Tiseo, Federico Quaini, Franco Aversa, Konrad Urbanek, Andrea Ardizzoni, Enrico Maria Silini, Michele Veneziani, Luca Ampollini, Roberta Alfieri, Caterina Frati, Rocchina Vilella, Chiara Mangiaracina, Bruno Lorusso, Costanza Annamaria Lagrasta, Giovanna Armani, Francesco Sogni, Matteo Goldoni, Giovanni Bocchialini, Angela Falco, Denise Madeddu, Giulia Mazzaschi
Purpose: The success of immune checkpoint inhibitors strengthens the notion that tumor growth and regression are immune regulated. To determine whether distinct tissue immune microenvironments differentially affect clinical outcome in non–small cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283f8b8062f0e685ada4fa6c649dee5b
https://doi.org/10.1158/1078-0432.c.6526485
https://doi.org/10.1158/1078-0432.c.6526485
Autor:
Marcello Tiseo, Federico Quaini, Franco Aversa, Konrad Urbanek, Andrea Ardizzoni, Enrico Maria Silini, Michele Veneziani, Luca Ampollini, Roberta Alfieri, Caterina Frati, Rocchina Vilella, Chiara Mangiaracina, Bruno Lorusso, Costanza Annamaria Lagrasta, Giovanna Armani, Francesco Sogni, Matteo Goldoni, Giovanni Bocchialini, Angela Falco, Denise Madeddu, Giulia Mazzaschi
Clinicopathological correlations. Figure S1: PD-L1 Expression and Clinicopathologic Parameters; Figure S2: PD-L1 Expression and TILs; Figure S3: TILs and Clinicopathological Parameters; Figure S4: NSCLC Immune Microenvironments Based on PD-L1 and TIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c040adf5602292e369f263808dee5e
https://doi.org/10.1158/1078-0432.22466943.v1
https://doi.org/10.1158/1078-0432.22466943.v1
Autor:
Marcello Tiseo, Federico Quaini, Franco Aversa, Konrad Urbanek, Andrea Ardizzoni, Enrico Maria Silini, Michele Veneziani, Luca Ampollini, Roberta Alfieri, Caterina Frati, Rocchina Vilella, Chiara Mangiaracina, Bruno Lorusso, Costanza Annamaria Lagrasta, Giovanna Armani, Francesco Sogni, Matteo Goldoni, Giovanni Bocchialini, Angela Falco, Denise Madeddu, Giulia Mazzaschi
Table S1. Antibodies for Immunohistochemistry; Table S2. Magnitude of Sampling; Table S3. Magnitude of Sampling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a0509ac01b82b62116d6b0a50cff9
https://doi.org/10.1158/1078-0432.22466940
https://doi.org/10.1158/1078-0432.22466940