Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Enrico Luchinat"'
Autor:
Begoña Alburquerque-González, Silvia Montoro-García, Ángel Bernabé-García, Manuel Bernabé-García, Priscila Campioni-Rodrigues, Alejandro Rodríguez-Martínez, Irene Luque, Tuula Salo, Alfonso Pérez-Garrido, Horacio Pérez-Sánchez, María Luisa Cayuela, Ginés Luengo-Gil, Enrico Luchinat, Fatima Postigo-Corrales, Tommaso Staderini, Francisco José Nicolás, Pablo Conesa-Zamora
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117411- (2024)
Externí odkaz:
https://doaj.org/article/2012b987a1934b849214c3d3ea5cdcaf
Autor:
Begoña Alburquerque-González, Silvia Montoro-García, Ángel Bernabé-García, Manuel Bernabé-García, Priscila Campioni-Rodrigues, Alejandro Rodríguez-Martínez, Irene Luque, Tuula Salo, Alfonso Pérez-Garrido, Horacio Pérez-Sánchez, María Luisa Cayuela, Ginés Luengo-Gil, Enrico Luchinat, Fatima Postigo-Corrales, Tommaso Staderini, Francisco José Nicolás, Pablo Conesa-Zamora
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116785- (2024)
Rearrangement of the actin cytoskeleton is a prerequisite for carcinoma cells to develop cellular protrusions, which are required for migration, invasion, and metastasis. Fascin is a key protein involved in actin bundling and is expressed in aggressi
Externí odkaz:
https://doaj.org/article/d5c1f0177bc1443697dce8edda81a4fc
Autor:
Stefano Conti Nibali, Silvia De Siervi, Enrico Luchinat, Andrea Magrì, Angela Messina, Lorenza Brocca, Stefania Mantovani, Barbara Oliviero, Mario U. Mondelli, Vito De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109853- (2024)
Summary: The voltage-dependent anion-selective channel isoform 1 (VDAC1) is a pivotal component in cellular metabolism and apoptosis with a prominent role in many cancer types, offering a unique therapeutic intervention point. Through an in-silico-to
Externí odkaz:
https://doaj.org/article/f8f8103a30764dd487a97d856a1dcc3f
Autor:
Panagis Polykretis, Enrico Luchinat, Alessio Bonucci, Andrea Giachetti, Melissa A. Graewert, Dmitri I. Svergun, Lucia Banci
Publikováno v:
IUCrJ, Vol 6, Iss 5, Pp 948-957 (2019)
The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeost
Externí odkaz:
https://doaj.org/article/4823975b7b3c4393a289fa2efb7ab3d4
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-product of glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced glycation end-products (AGEs). MG bind
Externí odkaz:
https://doaj.org/article/f2f3764273b74453a6d3652b8ddba150
Autor:
Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Mutations in superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Here the authors present the SOD1 crystal structure bound to the small cysteine-reactive molecule ebselen and show that ebselen is a chaperone for SOD1.
Externí odkaz:
https://doaj.org/article/d39dd025e5674f268976de0edbd8107d
Autor:
Meng-Meng Hou, Panagis Polykretis, Enrico Luchinat, Xiao Wang, Shen-Na Chen, Hui-Hui Zuo, Yin Yang, Jia-Liang Chen, Yansheng Ye, Conggang Li, Lucia Banci, Xun-Cheng Su
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The X-chromosome linked inhibitor of apoptosis (XIAP) is a multidomain metalloprotein involved in caspase inhibition and in copper homeostasis. It contains three zinc-binding baculoviral IAP repeats (BIR) domains, which are responsible for c
Externí odkaz:
https://doaj.org/article/19a844c194a644ec9b6abc7de73a76ed
Autor:
Enrico Luchinat, Lucia Banci
Publikováno v:
IUCrJ, Vol 4, Iss 2, Pp 108-118 (2017)
Classical structural biology approaches allow structural characterization of biological macromolecules in vitro, far from their physiological context. Nowadays, thanks to the wealth of structural data available and to technological and methodological
Externí odkaz:
https://doaj.org/article/9c605fffbe5c4bf299a178f5b08d5d64
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
Cadmium is a toxic pollutant that in recent decades has become more widespread in the environment due to anthropogenic activities, significantly increasing the risk of exposure. Concurrently, a continually growing body of research has begun to enumer
Externí odkaz:
https://doaj.org/article/9349e8f12c0f4197af989a73a78c1c23
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23561 (2011)
In-cell NMR allows characterizing the folding state of a protein as well as posttranslational events at molecular level, in the cellular context. Here, the initial maturation steps of human copper, zinc superoxide dismutase 1 are characterized in the
Externí odkaz:
https://doaj.org/article/774b5fc6322d426989d032988ab62c50