Ten-membered cyclotripeptides

Autor: Francesco Pinnen, Silvio Cerrini, Gino Lucente, Enrico Gavuzzo

Publikováno v: International Journal of Peptide and Protein Research. 31:447-453

The 10-membered cyclotripeptide cyclo(-MeβAla-Phe-Pro) 3 and its diastereoisomer cyclo(-MeβAla-Phe-dPro-) 4 have been synthesized under mild cyclization conditions starting from linear precursors containing C-terminal proline. The crystal and molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::404c8883dc317f64e755ba34c121a3e4
https://doi.org/10.1111/j.1399-3011.1988.tb00902.x

Crystal structure, conformation, and potential energy calculations the chemotactic peptide N- formyl-l-Met-l-Leu-l-Phe-OMe

Autor: Angelo Scatturin, Fernando Mazza, Enrico Gavuzzo, Giorgio Pochetti

Publikováno v: International Journal of Peptide and Protein Research. 34:409-415

The tripeptide N-formyl-L-Met-L-Leu-L-Phe-OMe (FMLP-OMe) crystallizes in the orthorhombic system, space group P 2(1)2(1)2(1), with the following unit-cell parameters: a = 21.727, b = 21.836, c = 5.133 A, Z = 4. The structure has been solved and refin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f52a48a5f849e10ec43c65efbfceeb
https://doi.org/10.1111/j.1399-3011.1989.tb00710.x

Oxyfunctionalization of Calixarene Quinone Rings

Autor: Lucia Citro, Carmine Gaeta, Enrico Gavuzzo, Francesco Troisi, Placido Neri

Publikováno v: Organic Letters. 10:1393-1396

The epoxidation of quinone rings of calixquinones represents a valid route for the introduction of oxygenated functionalities into the de-tert-butylated calixarene walls originating cis-diepoxy-p-dione moieties. Carbonyl reduction of these systems le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567476d342b8cd77bd921cfb73a24f92
https://doi.org/10.1021/ol800090u

Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Autor: Giovanni Maga, Enrico Gavuzzo, Roberto Di Santo, Ettore Novellino, Reynel Cancio, Roberto Cirilli, Antonio Lavecchia, Roberta Costi, Marino Artico, Rino Ragno, Francesco La Torre

Publikováno v: ChemMedChem
1 (2006): 82–95.
info:cnr-pdr/source/autori:Di Santo R, Costi R, Artico M, Ragno R, Lavecchia A, Novellino E, Gavuzzo E, La Torre F, Cirilli R, Cancio R, Maga G./titolo:Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors./doi:/rivista:ChemMedChem (Print)/anno:2006/pagina_da:82/pagina_a:95/intervallo_pagine:82–95/volume:1

TIBO- and TBO-like sulfone derivatives 1 and 2 were designed, synthesized, and tested for their ability to block the replication cycle of HIV-1 in infected cells. The anti-HIV-1 activities of sulfones 3, which were intermediates in the syntheses of 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f146452a874debfba76583059cecf1b
https://doi.org/10.1002/cmdc.200500020

[Untitled]

Autor: Harald Tschesche, Carlo Gallina, Alfredo Di Nola, Enrico Gavuzzo, Massimiliano Aschi, Danilo Roccatano, Giorgio Pochetti, Michael Pieper, Fernando Mazza

Publikováno v: Journal of Computer-Aided Molecular Design. 16:213-225

Human neutrophil collagenase (HNC, MMP-8) is one of the target enzymes for drug treatment of pathologic extracellular matrix degradation. Peptidomimetic inhibitors bind in the S'-side of the enzyme active site occupying the S-1(') primary specificity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5066de28dc94ce6c9cb67df8b25f0ab
https://doi.org/10.1023/a:1020178822319