Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Enrico Garaci"'
Autor:
Enrico Garaci, Maurizio Paci, Claudia Matteucci, Claudio Costantini, Paolo Puccetti, Luigina Romani
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Phenotypic drug discovery (PDD) involves screening compounds for their effects on cells, tissues, or whole organisms without necessarily understanding the underlying molecular targets. PDD differs from target-based strategies as it does not require k
Externí odkaz:
https://doaj.org/article/ace5ad83713d4462b1a644ba82daee81
Autor:
Giorgia Renga, Fiorella D’Onofrio, Marilena Pariano, Roberta Galarini, Carolina Barola, Claudia Stincardini, Marina M. Bellet, Helmut Ellemunter, Cornelia Lass-Flörl, Claudio Costantini, Valerio Napolioni, Allison K. Ehrlich, Cinzia Antognelli, Massimo Fini, Enrico Garaci, Emilia Nunzi, Luigina Romani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and microbial pathways. While much is known about the role played by downstream metabolites of each pathways in intestinal homeostasis, their role in lung i
Externí odkaz:
https://doaj.org/article/55ef849205bf4431a7d35facb0df52e6
Autor:
Matteo Antonio Russo, Enrico Garaci, Andrea Frustaci, Massimo Fini, Claudio Costantini, Vasileios Oikonomou, Emilia Nunzi, Paolo Puccetti, Luigina Romani
Publikováno v:
Pharmacological Research, Vol 198, Iss , Pp 106994- (2023)
The functional interdependencies between the molecular components of a biological process demand for a network medicine platform that integrates systems biology and network science, to explore the interactions among biological components in health an
Externí odkaz:
https://doaj.org/article/51db04e8693545ccb04c7977575554ad
Autor:
Giorgia Renga, Fiorella D’Onofrio, Marilena Pariano, Roberta Galarini, Carolina Barola, Claudia Stincardini, Marina M. Bellet, Helmut Ellemunter, Cornelia Lass-Flörl, Claudio Costantini, Valerio Napolioni, Allison K. Ehrlich, Cinzia Antognelli, Massimo Fini, Enrico Garaci, Emilia Nunzi, Luigina Romani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e48746aa645243f7ad232bb4f71c290e
Autor:
Chiara Cipriani, Martina Giudice, Vita Petrone, Marialaura Fanelli, Antonella Minutolo, Martino T. Miele, Nicola Toschi, Christian Maracchioni, Martina Siracusano, Arianna Benvenuto, Antonella Coniglio, Paolo Curatolo, Luigi Mazzone, Grelli Sandro, Enrico Garaci, Paola Sinibaldi-Vallebona, Claudia Matteucci, Emanuela Balestrieri
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in humans have been extensively described. HERVs may alter the development of the brain by means of several me
Externí odkaz:
https://doaj.org/article/91ce9a445e9f484b99b17830897ae4ae
Autor:
Vita Petrone, Marialaura Fanelli, Martina Giudice, Nicola Toschi, Allegra Conti, Christian Maracchioni, Marco Iannetta, Claudia Resta, Chiara Cipriani, Martino Tony Miele, Francesca Amati, Massimo Andreoni, Loredana Sarmati, Paola Rogliani, Giuseppe Novelli, Enrico Garaci, Guido Rasi, Paola Sinibaldi-Vallebona, Antonella Minutolo, Claudia Matteucci, Emanuela Balestrieri, Sandro Grelli
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionOur research group and others demonstrated the implication of the human endogenous retroviruses (HERVs) in SARS-CoV-2 infection and their association with disease progression, suggesting HERVs as contributing factors in COVID-19 immunopat
Externí odkaz:
https://doaj.org/article/48d27bb09a824551806ea8541eaf86da
Autor:
Eleonora Foglio, Erica D’Avorio, Laura Vitiello, Laura Masuelli, Roberto Bei, Francesca Pacifici, David Della-Morte, Simone Mirabilii, Maria Rosaria Ricciardi, Agostino Tafuri, Enrico Garaci, Matteo Antonio Russo, Marco Tafani, Federica Limana
Publikováno v:
Cells, Vol 12, Iss 22, p 2605 (2023)
Oxidative stress and impaired mitophagy are the hallmarks of cardiomyocyte senescence. Specifically, a decrease in mitophagic flux leads to the accumulation of damaged mitochondria and the development of senescence through increased ROS and other med
Externí odkaz:
https://doaj.org/article/5ce0e99c63c144068c234f25ab76bd6b
Autor:
Claudia Fredolini, Khyatiben V. Pathak, Luisa Paris, Kristina M. Chapple, Kristine A. Tsantilas, Matthew Rosenow, Tony J. Tegeler, Krystine Garcia-Mansfield, Davide Tamburro, Weidong Zhou, Paul Russo, Samuele Massarut, Francesco Facchiano, Claudio Belluco, Ruggero De Maria, Enrico Garaci, Lance Liotta, Emanuel F. Petricoin, Patrick Pirrotte
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background The lack of specificity and high degree of false positive and false negative rates when using mammographic screening for detecting early-stage breast cancer is a critical issue. Blood-based molecular assays that could be used in a
Externí odkaz:
https://doaj.org/article/52c832efeb984d1080526646a3f96583
Autor:
Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di Daniele, Enrico Garaci, Massimiliano Caprio, David Della-Morte
Publikováno v:
Cells, Vol 12, Iss 5, p 714 (2023)
Background: Obesity is a pandemic disease characterized by excessive severe body comorbidities. Reduction in fat accumulation represents a mechanism of prevention, and the replacement of white adipose tissue (WAT) with brown adipose tissue (BAT) has
Externí odkaz:
https://doaj.org/article/c4789e558e814104bb7de77dd09b051f
Autor:
Chiara Cipriani, Anna Maria Tartaglione, Martina Giudice, Erica D’Avorio, Vita Petrone, Nicola Toschi, Flavia Chiarotti, Martino Tony Miele, Gemma Calamandrei, Enrico Garaci, Claudia Matteucci, Paola Sinibaldi-Vallebona, Laura Ricceri, Emanuela Balestrieri
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13930 (2022)
Maternal infections during pregnancy and the consequent maternal immune activation (MIA) are the major risk factors for autism spectrum disorder (ASD). Epidemiological evidence is corroborated by the preclinical models in which MIA leads to ASD-like
Externí odkaz:
https://doaj.org/article/8fa4167853bd4cf9866d3f10a973e69c