Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Enrico Cancellotti"'
Autor:
Nadia L Tuzi, Enrico Cancellotti, Herbert Baybutt, Lorraine Blackford, Barry Bradford, Chris Plinston, Anne Coghill, Patricia Hart, Pedro Piccardo, Rona M Barron, Jean C Manson
Publikováno v:
PLoS Biology, Vol 6, Iss 4, p e100 (2008)
The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host Pr
Externí odkaz:
https://doaj.org/article/cded1fa5196a4c4c9b1ac21ceeb8db25
Autor:
Jean Manson, Enrico Cancellotti, G. Robin Barclay, Kay Samuel, Paul A. De Sousa, Matthew Bishop, Steve Pells, Mark Head, Zuzana Krejciova, James W. Ironside, Marc Turner, Paz Freile
Publikováno v:
The Journal of Pathology. 223:635-645
Susceptibility to prion infection involves interplay between the prion strain and host genetics, but expression of the host-encoded cellular prion protein is a known prerequisite. Here we consider human embryonic stem cell (hESC) susceptibility by ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db238f4dfe3fd5e4a9053b90e37211d
https://doi.org/10.1002/path.2832
https://doi.org/10.1002/path.2832
Autor:
Arianna Calistri, Cristina Forghieri, Heinrich G. Göttlinger, Cristiano Salata, Paola Sette, Cristina Parolin, Enrico Cancellotti, Giorgio Palù, Alessandra Comin, Gabriella Campadelli-Fiume
Publikováno v:
Journal of Virology. 81:11468-11478
The biogenesis of multivesicular bodies (MVBs) is topologically equivalent to virion budding. Hence, a number of viruses exploit the MVB pathway to build their envelope and exit from the cell. By expression of dominant negative forms of Vps4 and Vps2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ea7b5678625079f99c6b59a579bb0e
https://doi.org/10.1128/jvi.01364-07
https://doi.org/10.1128/jvi.01364-07
Autor:
Jean Manson, Patricia Hart, Frances K. Wiseman, Matthew Bishop, Enrico Cancellotti, Rona Barron
Publikováno v:
Cancellotti, E, Barron, R M, Bishop, M T, Hart, P, Wiseman, F & Manson, J C 2007, ' The role of host PrP in Transmissible Spongiform Encephalopathies ', BBA-Proteins and Proteomics, vol. 1772, no. 6, pp. 673-80 . https://doi.org/10.1016/j.bbadis.2006.10.013
PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743b559fc3e2fc23fbf092b1ee3ecb90
https://doi.org/10.1016/j.bbadis.2006.10.013
https://doi.org/10.1016/j.bbadis.2006.10.013
Publikováno v:
Biochemical Society Transactions. 34:1155-1158
TSEs (transmissible spongiform encephalopathies) are neurodegenerative diseases of various mammalian species, the best known of which include BSE (bovine spongiform encephalopathies) in cattle, CJD (Creutzfeldt–Jakob disease) in humans, scrapie in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1d6ca2a13001de657c331cc17a926
https://doi.org/10.1042/bst0341155
https://doi.org/10.1042/bst0341155
Autor:
Elisa Piaia, Emanuele Papini, Giorgio Palù, Arianna Loregian, Howard S. Marsden, Enrico Cancellotti
Publikováno v:
Università degli Studi di Padova-IRIS
The herpes simplex virus type 1 DNA polymerase consists of a catalytic subunit (POL or UL30) and a processivity factor (UL42). The POL/UL42 interaction, which occurs through the extreme C-terminus of POL, is essential for HSV-1 replication and thus r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc21b267cae62fb27fcbd0271ae682e0
https://doi.org/10.1006/viro.2000.0390
https://doi.org/10.1006/viro.2000.0390
Autor:
Rona Wilson, Matthew Bishop, Barry Bradford, Jean Manson, Abigail B. Diack, Enrico Cancellotti
Publikováno v:
Prions and Diseases ISBN: 9781461453376
Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d47b5f891fc6ad95b107b070ae8ff7
https://doi.org/10.1007/978-1-4614-5338-3_10
https://doi.org/10.1007/978-1-4614-5338-3_10
Autor:
Robert A. Somerville, Pedro Piccardo, Jean Manson, Deborah Brown, Abigail B. Diack, Sukhvir P. Mahal, Charles Weissmann, Enrico Cancellotti
Publikováno v:
The EMBO journal. 32(5)
Central to understanding the nature TSE agents (or prions) is how their genetic information is distinguished from the host. Are TSEs truly infectious diseases with host-independent genomes, or are they aberrations of a host component derived from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f254ad22af54f8033196a1aacc37dd17
https://pubmed.ncbi.nlm.nih.gov/23787696
https://pubmed.ncbi.nlm.nih.gov/23787696
Autor:
Barry Bradford, Rona Barron, Karen L. Brown, Nadia L. Tuzi, Pedro Piccardo, Jean Manson, Debbie Brown, Dorothy Kisielewski, Raymond Hickey, Enrico Cancellotti
Publikováno v:
Cancellotti, E, Bradford, B, Tuzi, N L, Hickey, R D, Brown, D, Brown, K L, Barron, R M, Kisielewski, D, Piccardo, P & Manson, J C 2010, ' Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route ', Journal of Virology, vol. 84, no. 7, pp. 3464-75 . https://doi.org/10.1128/JVI.02374-09
Transmissible spongiform encephalopathy (TSE) infectivity naturally spreads from site of entry in the periphery to the central nervous system where pathological lesions are formed. Several routes and cells within the host have been identified as impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1677411efd9369c6104243d5e5a50e
https://europepmc.org/articles/PMC2838100/
https://europepmc.org/articles/PMC2838100/
Autor:
Nadia L. Tuzi, M. Laura Feltri, Enrico Cancellotti, Caroline McCorquodale, Barry Bradford, Jean Manson
Publikováno v:
Bradford, B M, Tuzi, N L, Feltri, M L, McCorquodale, C, Cancellotti, E & Manson, J C 2009, ' Dramatic Reduction of PrPC Level and Glycosylation in Peripheral Nerves following PrP Knock-Out from Schwann Cells Does Not Prevent Transmissible Spongiform Encephalopathy Neuroinvasion ', Journal of Neuroscience, vol. 29, no. 49, pp. 15445-15454 . https://doi.org/10.1523/JNEUROSCI.4195-09.2009
Expression of the prion protein (PrPC) is a requirement for host susceptibility to the transmissible spongiform encephalopathies (TSEs) and thought to be necessary for the replication and transport of the infectious agent. The mechanism of TSE neuroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff21ce45548f28b1a264574a9c4e45d
https://hdl.handle.net/20.500.11820/ff92c4af-f615-4626-ad87-93a3442738d1
https://hdl.handle.net/20.500.11820/ff92c4af-f615-4626-ad87-93a3442738d1