Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Enrico Calzia"'
Autor:
Eva-Maria Wolfschmitt, Josef Albert Vogt, Melanie Hogg, Ulrich Wachter, Nicole Stadler, Thomas Kapapa, Thomas Datzmann, David Alexander Christian Messerer, Andrea Hoffmann, Michael Gröger, Franziska Münz, René Mathieu, Simon Mayer, Tamara Merz, Pierre Asfar, Enrico Calzia, Peter Radermacher, Fabian Zink
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionSupplementation with increased inspired oxygen fractions has been suggested to alleviate the harmful effects of tissue hypoxia during hemorrhagic shock (HS) and traumatic brain injury. However, the utility of therapeutic hyperoxia in crit
Externí odkaz:
https://doaj.org/article/991bb70120ea4070bfbfec8007e78d77
Autor:
Franziska Münz, Eva-Maria Wolfschmitt, Fabian Zink, Nadja Abele, Melanie Hogg, Andrea Hoffmann, Michael Gröger, Enrico Calzia, Christiane Waller, Peter Radermacher, Tamara Merz
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Early Life Stress (ELS) may exert long-lasting biological effects, e.g., on PBMC energy metabolism and mitochondrial respiration. Data on its effect on brain tissue mitochondrial respiration is scarce, and it is unclear whether blood cell
Externí odkaz:
https://doaj.org/article/b3a7279e7731410b83c8f6b45831d5d9
Autor:
Thomas Datzmann, Franziska Münz, Andrea Hoffmann, Elena Moehrke, Martha Binzenhöfer, Michael Gröger, Thomas Kapapa, René Mathieu, Simon Mayer, Fabian Zink, Holger Gässler, Eva-Maria Wolfschmitt, Melanie Hogg, Tamara Merz, Enrico Calzia, Peter Radermacher, David Alexander Christian Messerer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Severe physical injuries and associated traumatic brain injury and/or hemorrhagic shock (HS) remain leading causes of death worldwide, aggravated by accompanying extensive inflammation. Retrospective clinical data indicated an association between mil
Externí odkaz:
https://doaj.org/article/debf330e5b544e33aff93261da4552b1
Autor:
Eva-Maria Wolfschmitt, Melanie Hogg, Josef Albert Vogt, Fabian Zink, Ulrich Wachter, Felix Hezel, Xiaomin Zhang, Andrea Hoffmann, Michael Gröger, Clair Hartmann, Holger Gässler, Thomas Datzmann, Tamara Merz, Andreas Hellmann, Christine Kranz, Enrico Calzia, Peter Radermacher, David Alexander Christian Messerer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSodium thiosulfate (Na2S2O3), an H2S releasing agent, was shown to be organ-protective in experimental hemorrhage. Systemic inflammation activates immune cells, which in turn show cell type-specific metabolic plasticity with modifications
Externí odkaz:
https://doaj.org/article/6aec3c551b6a4003a7c9b5ece2534655
Autor:
Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionWe previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, whic
Externí odkaz:
https://doaj.org/article/23e5c3a8c9d64ee397a1cb91a3748c37
Autor:
Julien Demiselle, Enrico Calzia, Clair Hartmann, David Alexander Christian Messerer, Pierre Asfar, Peter Radermacher, Thomas Datzmann
Publikováno v:
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract There is an ongoing discussion whether hyperoxia, i.e. ventilation with high inspiratory O2 concentrations (FIO2), and the consecutive hyperoxaemia, i.e. supraphysiological arterial O2 tensions (PaO2), have a place during the acute managemen
Externí odkaz:
https://doaj.org/article/2152f07201ee41679d4cfb5d4e6cad90
Autor:
Thomas Datzmann, David Alexander Christian Messerer, Franziska Münz, Andrea Hoffmann, Michael Gröger, René Mathieu, Simon Mayer, Holger Gässler, Fabian Zink, Oscar McCook, Tamara Merz, Angelika Scheuerle, Eva-Maria Wolfschmitt, Timo Thebrath, Stefan Zuech, Enrico Calzia, Pierre Asfar, Peter Radermacher, Thomas Kapapa
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Controversial evidence is available regarding suitable targets for the arterial O2 tension (PaO2) after traumatic brain injury and/or hemorrhagic shock (HS). We previously demonstrated that hyperoxia during resuscitation from hemorrhagic shock attenu
Externí odkaz:
https://doaj.org/article/b1725e65ff31413fa4f25e0e77c07d69
Autor:
David Alexander Christian Messerer, Holger Gaessler, Andrea Hoffmann, Michael Gröger, Kathrin Benz, Aileen Huhn, Felix Hezel, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We previously demonstrated marked lung-protective properties of the H2S donor sodium thiosulfate (Na2S2O3, STS) in a blinded, randomized, controlled, long-term, resuscitated porcine model of swine with coronary artery disease, i.e., with decreased ex
Externí odkaz:
https://doaj.org/article/41da93773c814396b9e39800ddbf7ace
Autor:
Michael Gröger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Enrico Calzia, Ulrich Wachter, Josef A. Vogt, Rui Wang, Tamara Merz, Peter Radermacher, Oscar McCook
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundSodium thiosulfate (STS) is a recognized drug with antioxidant and H2S releasing properties. We recently showed that STS attenuated organ dysfunction and injury during resuscitation from trauma-and-hemorrhage in CSE-ko mice, confirming its
Externí odkaz:
https://doaj.org/article/5852a9f2d8724d0f8815db5a277c1564
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-19 (2020)
Abstract Neuronal stress-adaptation combines multiple molecular responses. We have previously reported that thorax trauma induces a transient loss of hippocampal excitatory synapses mediated by the local release of the stress-related hormone corticot
Externí odkaz:
https://doaj.org/article/e423195648044692a6e3de72b9564e81