ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

Autor: Cristina Terlizzi, Viviana De Rosa, Francesca Iommelli, Antonio Pezone, Giovanna G. Altobelli, Maurizio Maddalena, Jelena Dimitrov, Caterina De Rosa, Carminia Maria Della Corte, Vittorio Enrico Avvedimento, Silvana Del Vecchio

Publikováno v: Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)

Abstract Background ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic

Externí odkaz: https://doaj.org/article/e83d3991835d4c898a45587c3d859097

Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene

Autor: Ermanno Florio, Simona Keller, Lorena Coretti, Ornella Affinito, Giovanni Scala, Francesco Errico, Annalisa Fico, Francesca Boscia, Maria Josè Sisalli, Mafalda Giovanna Reccia, Gennaro Miele, Antonella Monticelli, Antonella Scorziello, Francesca Lembo, Luca Colucci-D'Amato, Gabriella Minchiotti, Vittorio Enrico Avvedimento, Alessandro Usiello, Sergio Cocozza, Lorenzo Chiariotti

Publikováno v: Epigenetics, Vol 12, Iss 1, Pp 41-54 (2017)

We performed ultra-deep methylation analysis at single molecule level of the promoter region of developmentally regulated D-Aspartate oxidase (Ddo), as a model gene, during brain development and embryonic stem cell neural differentiation. Single mole

Externí odkaz: https://doaj.org/article/a9478b179b47438f8014f2f51a8cedd1

5-Hydroxytryptamine Modulates Maturation and Mitochondria Function of Human Oligodendrocyte Progenitor M03-13 Cells

Autor: Gina Cavaliere, Giuliana La Rosa, Maddalena Raia, Concetta Sozio, Mariarosaria Santillo, Vittorio Enrico Avvedimento, Giovanna Trinchese, Maria Pina Mollica, Simona Damiano, Roberto Paternò

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2621, p 2621 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 5

Inside the adult CNS, oligodendrocyte progenitor cells (OPCS) are able to proliferate, migrate and differentiate into mature oligodendrocytes (OLs) which are responsible for the production of myelin sheet and energy supply for neurons. Moreover, in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8802da7ddbf787b424f71899da09c6b2
https://www.mdpi.com/1422-0067/22/5/2621

Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum

Autor: Daniela Punzo, Mariella Cuomo, Ornella Affinito, Tommaso Nuzzo, Francesco Errico, Massimo Carella, Valeria de Rosa, Francesca Boscia, Lorenzo Chiariotti, Lorena Coretti, Ermanno Florio, Alessandro Usiello, Vittorio Enrico Avvedimento, Simona Keller, Sergio Cocozza

Publikováno v: Clinical epigenetics (Internet) 11 (2019). doi:10.1186/s13148-019-0732-z
info:cnr-pdr/source/autori:Cuomo M.; Keller S.; Punzo D.; Nuzzo T.; Affinito O.; Coretti L.; Carella M.; De Rosa V.; Florio E.; Boscia F.; Avvedimento V.E.; Cocozza S.; Errico F.; Usiello A.; Chiariotti L./titolo:Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum/doi:10.1186%2Fs13148-019-0732-z/rivista:Clinical epigenetics (Internet)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Clinical Epigenetics

Background Programmed epigenetic modifications occurring at early postnatal brain developmental stages may have a long-lasting impact on brain function and complex behavior throughout life. Notably, it is now emerging that several genes that undergo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0956ab04fedef01bf22ebc76c8be0c3
https://doi.org/10.1186/s13148-019-0732-z

EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB

Autor: Patrizia Sarogni, Simona Paladino, Vittorio Enrico Avvedimento, Gabriele G. Schiattarella, Valeria De Pasquale, Alfonso Tramontano, Luigi Michele Pavone, Antonio Pezone

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-16 (2018)
Cell death and disease 9 (2018). doi:10.1038/s41419-017-0187-0
info:cnr-pdr/source/autori:De Pasquale V.; Pezone A.; Sarogni P.; Tramontano A.; Schiattarella G.G.; Avvedimento V.E.; Paladino S.; Pavone L.M./titolo:EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB/doi:10.1038%2Fs41419-017-0187-0/rivista:Cell death and disease/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation. The defective lysosomal clearance of undigested HS res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab78dbb7cf779f7077b71a56951bb32
https://doi.org/10.1038/s41419-017-0187-0