Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Enrico, Lugli"'
Autor:
Simone Puccio, Giorgio Grillo, Giorgia Alvisi, Caterina Scirgolea, Giovanni Galletti, Emilia Maria Cristina Mazza, Arianna Consiglio, Gabriele De Simone, Flavio Licciulli, Enrico Lugli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Flow cytometry (FCM) can investigate dozens of parameters from millions of cells and hundreds of specimens in a short time and at a reasonable cost, but the amount of data that is generated is considerable. Computational approaches are usefu
Externí odkaz:
https://doaj.org/article/e69aeb7b37e6417ba998bb41ae9cf3e2
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals,
Externí odkaz:
https://doaj.org/article/d4f8b6047e124e2e9dec910837cb8925
Autor:
Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, Teresa Manzo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce
Externí odkaz:
https://doaj.org/article/d39113774e5e4720a4cf6ac291ef21d3
Autor:
Agnese Losurdo, Caterina Scirgolea, Giorgia Alvisi, Jolanda Brummelman, Valentina Errico, Luca Di Tommaso, Karolina Pilipow, Federico Simone Colombo, Bethania Fernandes, Clelia Peano, Alberto Testori, Corrado Tinterri, Massimo Roncalli, Armando Santoro, Emilia Maria Cristina Mazza, Enrico Lugli
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Losurdo et al analyze breast cancer-infiltrating T cells by single-cell technologies . The find that the extent of infiltration of a small subset of tissue-resident memory CD8+ T cells identify patients with improved survival, highlighting the import
Externí odkaz:
https://doaj.org/article/ffe170fd97a449cfa53c352030435be9
Autor:
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentage
Externí odkaz:
https://doaj.org/article/5dde8cd7955f4749b3113f29084ac913
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Autor:
Hassen Kared, Shu Wen Tan, Mai Chan Lau, Marion Chevrier, Crystal Tan, Wilson How, Glenn Wong, Marie Strickland, Benoit Malleret, Amanda Amoah, Karolina Pilipow, Veronica Zanon, Naomi Mc Govern, Josephine Lum, Jin Miao Chen, Bernett Lee, Maria Carolina Florian, Hartmut Geiger, Florent Ginhoux, Ezequiel Ruiz-Mateos, Tamas Fulop, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Enrico Lugli, Anis Larbi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced st
Externí odkaz:
https://doaj.org/article/d05913b802064e6bbba5a639e2f712a7
Autor:
Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109871- (2021)
Summary: Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer.
Externí odkaz:
https://doaj.org/article/05645d72a7ba409498bd2a6ec58b97fb
Autor:
Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, Teresa Manzo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/8a4381a2c8fa43b69113cd0ea77d9041
Autor:
Jasper J. P. van Beek, Simone Puccio, Alessandra Roberto, Federica De Paoli, Giulia Graziano, Elisa Salviato, Giorgia Alvisi, Veronica Zanon, Alice Scarpa, Elisa Zaghi, Michela Calvi, Clara Di Vito, Rossana Mineri, Barbara Sarina, Chiara De Philippis, Armando Santoro, Jacopo Mariotti, Stefania Bramanti, Francesco Ferrari, Luca Castagna, Domenico Mavilio, Enrico Lugli
Publikováno v:
Haematologica, Vol 106, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/8835ea38efbf46e0834e70bf9e5a3d33
Autor:
Elisa Zaghi, Michela Calvi, Simone Puccio, Gianmarco Spata, Sara Terzoli, Clelia Peano, Alessandra Roberto, Federica De Paoli, Jasper J.P. van Beek, Jacopo Mariotti, Chiara De Philippis, Barbara Sarina, Rossana Mineri, Stefania Bramanti, Armando Santoro, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Emanuela Marcenaro, Luca Castagna, Clara Di Vito, Enrico Lugli, Domenico Mavilio
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient curative approach for patients affected by hematologic malignancies in which the reduced intensity conditioning induces a state of immunologic tolerance between d
Externí odkaz:
https://doaj.org/article/0a56f5f4bf464fbf844eb17c2cc2c103