Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Enrico, Di Cera"'
Autor:
Norah G. Verbout, Christina U. Lorentz, Brandon D. Markway, Michael Wallisch, Thomas C. Marbury, Enrico Di Cera, Joseph J. Shatzel, András Gruber, Erik I. Tucker
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background The protein C system regulates blood coagulation, inflammation, and vascular integrity. AB002 is an injectable protein C activating enzyme under investigation to safely prevent and treat thrombosis. In preclinical models, AB002 is
Externí odkaz:
https://doaj.org/article/de9625889c004a0a9813402404b9f1bc
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 7, Pp n/a-n/a (2022)
Abstract A State of the Art lecture titled “Cryo‐EM structures of coagulation factors” was presented at the ISTH Congress in 2022. Cryogenic electron microscopy (cryo‐EM) is a revolutionary technique capable of solving the structure of high m
Externí odkaz:
https://doaj.org/article/9bf0407086324aaf8c9481a3d6fa9262
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease conversion of protein C involves removal of a short activation peptide that, relative to the analogo
Externí odkaz:
https://doaj.org/article/21d2d7669254469895a25cc38ee0ab1c
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1651 (2022)
Allostery is a property of biological macromolecules featuring cooperative ligand binding and regulation of ligand affinity by effectors. The definition was introduced by Monod and Jacob in 1963, and formally developed as the “concerted model” by
Externí odkaz:
https://doaj.org/article/3754f33927b440b2bd0ebf42ab81bf11
Autor:
Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Adrian R. Ferré-D'Amaré, J. Christopher Fromme, K. Christopher Garcia, Rachelle Gaudet, Peng Gong, Stephen C. Harrison, Ekaterina E. Heldwein, Zongchao Jia, Robert J. Keenan, Andrew C. Kruse, Marc Kvansakul, Jason S. McLellan, Yorgo Modis, Yunsun Nam, Zbyszek Otwinowski, Emil F. Pai, Pedro José Barbosa Pereira, Carlo Petosa, C. S. Raman, Tom A. Rapoport, Antonina Roll-Mecak, Michael K. Rosen, Gabby Rudenko, Joseph Schlessinger, Thomas U. Schwartz, Yousif Shamoo, Holger Sondermann, Yizhi J. Tao, Niraj H. Tolia, Oleg V. Tsodikov, Kenneth D. Westover, Hao Wu, Ian Foster, James S. Fraser, Filipe R. N C. Maia, Tamir Gonen, Tom Kirchhausen, Kay Diederichs, Mercè Crosas, Piotr Sliz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it cou
Externí odkaz:
https://doaj.org/article/72383da3679147f9a2668c703d709d2e
Publikováno v:
Blood.
Coagulation factor V (fV) is the inactive precursor of fVa, an essential component of the prothrombinase complex required for rapid activation of prothrombin in the penultimate step of the coagulation cascade. In addition, fV regulates the tissue fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61834e980219834f79bbcd183b53e3f
https://doi.org/10.1182/blood.2022019486
https://doi.org/10.1182/blood.2022019486
Autor:
Bosko M. Stojanovski, Enrico Di Cera
Publikováno v:
Journal of Thrombosis and Haemostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83c373f259ef9c5d6e41202732a2dbc
https://doi.org/10.1016/j.jtha.2023.03.008
https://doi.org/10.1016/j.jtha.2023.03.008
Autor:
Mohanram Sivaraja, Nicola Pozzi, Matthew Rienzo, Kenneth Lin, Timothy P Shiau, Daniel M Clemens, Lev Igoudin, Piotr Zalicki, Stephanie S Chang, M Angels Estiarte, Kevin M Short, David C Williams, Anirban Datta, Enrico Di Cera, David B Kita
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201377 (2018)
INTRODUCTION:In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants offering convenient dosing regimens, more predictable anticoagulant responses, and le
Externí odkaz:
https://doaj.org/article/f610424ff315488398aaec24e248f870
Autor:
Bosko M. Stojanovski, Enrico Di Cera
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 20(12)
Prothrombin, protein C, and factors VII, IX, and X are vitamin K (VK)-dependent coagulation proteins that play an important role in the initiation, amplification, and subsequent attenuation of the coagulation response. Blood coagulation evolved in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d9a626de5da833963b5df8e3cab1e3
https://pubmed.ncbi.nlm.nih.gov/36156849
https://pubmed.ncbi.nlm.nih.gov/36156849
Autor:
Kevin M. Short, M. Angels Estiarte, Son M. Pham, David C. Williams, Lev Igoudin, Subhadra Dash, Nichole Sandoval, Anirban Datta, Nicola Pozzi, Enrico Di Cera, David B. Kita
Publikováno v:
European journal of medicinal chemistry. 246
Direct oral anticoagulants (DOACs), which includes thrombin and factor Xa inhibitors, have emerged as the preferred therapeutics for thrombotic disorders, penetrating a market previously dominated by warfarin and heparin. This article describes the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a05f2d05fe5a9e8b7312ae3170e2775
https://pubmed.ncbi.nlm.nih.gov/36462436
https://pubmed.ncbi.nlm.nih.gov/36462436