Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1

Autor: Serena Barilla, Ning Liang, Enrichetta Mileti, Raphaëlle Ballaire, Marie Lhomme, Maharajah Ponnaiah, Sophie Lemoine, Antoine Soprani, Jean-Francois Gautier, Ez-Zoubir Amri, Wilfried Le Goff, Nicolas Venteclef, Eckardt Treuter

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101066- (2020)

Objective: Adipogenesis is critical for adipose tissue remodeling during the development of obesity. While the role of transcription factors in the orchestration of adipogenic pathways is already established, the involvement of coregulators that tran

Externí odkaz: https://doaj.org/article/f460bff5fd63430e99e9c9d70a40b52d

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Autor: Amitha Raman, Enrichetta Mileti, Hui Gao, Jesper Bäckdahl, Mikael Rydén, Carsten O. Daub, Anthony Mathelier, Peter Arner, Niklas Mejhert, Daniel P. Andersson, Lucas Massier, Jutta Jalkanen, Anders Thorell, Kelvin Ho Man Kwok

Publikováno v: diabetes

Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether similar mechanisms operate in white adipose tissue (WAT) of obese subjects and to what extent these are normalized by weight loss is unknown. We determined insu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c5f65c68ed22c9c64a0356c0935067
https://pubmed.ncbi.nlm.nih.gov/33863803

The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity

Autor: Olga Hrydziuszko, Daniel P. Andersson, Enrichetta Mileti, Eva Toft, Erik Näslund, Albin Sandelin, Veronica Qvist, Peter Arner, Anders Thorell, Mette Boyd, Carsten O. Daub, Ingrid Dahlman, Mikael Rydén, Jette Bornholdt, Amitha Raman, Hui Gao

Publikováno v: Cell Reports, Vol 16, Iss 9, Pp 2317-2326 (2016)
Rydén, M, Hrydziuszko, O, Mileti, E, Raman, A, Lange, J B, Boyd, M, Toft, E, Qvist, V, Näslund, E, Thorell, A, Andersson, D P, Dahlman, I, Gao, H, Sandelin, A G, Daub, C O & Arner, P 2016, ' The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity ', Cell Reports, vol. 16, no. 9, pp. 2317-2326 . https://doi.org/10.1016/j.celrep.2016.07.070

Summary Metabolically healthy obese subjects display preserved insulin sensitivity and a beneficial white adipose tissue gene expression pattern. However, this observation stems from fasting studies when insulin levels are low. We investigated adipos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3ab6fe824deac14746625ee2013319
http://www.sciencedirect.com/science/article/pii/S2211124716310142

Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1

Autor: Antoine Soprani, Nicolas Venteclef, Serena Barilla, Enrichetta Mileti, Sophie Lemoine, Ez-Zoubir Amri, Jean-François Gautier, Eckardt Treuter, Ning Liang, Marie Lhomme, Wilfried Le Goff, Raphaelle Ballaire, Maharajah Ponnaiah

Publikováno v: Molecular metabolism
Molecular metabolism, 2020, 42, pp.101066. ⟨10.1016/j.molmet.2020.101066⟩
Molecular metabolism, Elsevier, 2020, 42, pp.101066. ⟨10.1016/j.molmet.2020.101066⟩
Molecular Metabolism, Vol 42, Iss, Pp 101066-(2020)
Molecular Metabolism

Objective Adipogenesis is critical for adipose tissue remodeling during the development of obesity. While the role of transcription factors in the orchestration of adipogenic pathways is already established, the involvement of coregulators that trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b27cfb00166c7061241b8a8a0622f00