Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Enrica Diodato"'
Autor:
Carla Scali, Filippo Caraci, Marco Gianfriddo, Enrica Diodato, Renza Roncarati, Giuseppe Pollio, Giovanni Gaviraghi, Agata Copani, Ferdinando Nicoletti, Georg C. Terstappen, Andrea Caricasole
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 254-265 (2006)
Expression of the Wnt antagonist Dickkopf-1 (DKK1) is induced during neurodegenerative processes associated with Alzheimer's Disease and brain ischemia. However, little is known about DKK1-mediated effects on neurons. We now describe that, in culture
Externí odkaz:
https://doaj.org/article/961a1ad2de92453984cd0009a2e55199
Autor:
Giovanna Tripepi, Ruth Farmer, Salman Haider, Monika Rudzińska, G Westerberg, Sebastian Brzozy, Karin Schiefele, Elisa Mori, Letizia Magnoni, Michael Orth, Sarah J. Tabrizi, Ralph Andre, Marco Di Bacco, Carsten Saft, Danuta Ryglewicz, Giuseppe Pollio, Daniela Diamanti, Chris Frost, Claus A. Andersen, Sigurd D. Süssmuth, Enrica Diodato, Luisa Massai, Jens Dreyhaupt, Claudia Lamanna, Anna Baran, Borje Darpo, David Craufurd, G. Bernhard Landwehrmeyer
Publikováno v:
British Journal of Clinical Pharmacology. 79:465-476
AIMS: Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease-modifying therapeutic for Huntington's disease (HD). This was the first study of selisistat in HD patients and was primarily aimed at development of pharmacodyn
Autor:
Giuseppe Pollio, Costanza Fondelli, Alessia Tarditi, Daniela Diamanti, Letizia Magnoni, Andrea Caricasole, Giovanna Tripepi, Elisa Mori, Enrica Diodato, Federico Malusa, Sarah J. Tabrizi, Emilia Morena, Nayana Lahiri
Publikováno v:
Journal of Huntington's Disease. 2:185-200
BACKGROUND: Huntington's disease is a neurodegenerative disorder characterized by transcriptional alterations both in central and peripheral tissues. Therefore, the identification of a transcriptional signature in an accessible tissue can meaningfull
Autor:
Silvia Valensin, Enrica Diodato, Elena Pilli, Carla Scali, Luisa Massai, Roberta Magrini, Riccardo Roggeri, Antonella De Rosa, Fabio A. Recchia, Nicola P. Caradonna, Sara Chellini, Giuseppe Pollio, Patrizia Tunici, Valentina Porcari, Gianluca Sardone, Pasquale Fiengo, Letizia Magnoni, Silvia Coniglio, Vincenzo Lionetti, Daniela Diamanti, Martina Monti, Marco Rossi
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 86
Preclinical imaging modalities represent an essential tool to develop a modern and translational biomedical research. To date, Optical Imaging (OI) and Magnetic Resonance Imaging (MRI) are used principally in separate studies for molecular imaging st
Autor:
Georg C. Terstappen, Eva Genesio, Elena Pecchioli, Letizia Magnoni, Enrica Diodato, Chiara Ghiron, Pier Vincenzo Plazzi, Giovanni Gaviraghi, Andrea Caricasole, Giuseppe Cocconcelli
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2043-2052
A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in an in vitro assay using a NMDA toxicity paradigm showing a neuroprotective activity between 15% and 40%. The potential biological
Autor:
Shane A. Worthge, Adeela Syed, Letizia Magnoni, Michela Camarri, Liliana B. Menalled, J. Lawrence Marsh, Andrea Caricasole, Marco Gianfriddo, Enrica Diodato, Tamas Lukacsovich, Ruth Luthi-Carter, Ozgun Gokce, Judy Purcell, Marianne R. Smith, Luisa Massai, Sylvie Ramboz, Stephen R. Wei, Davide Franceschini, Russell J. Thomas, Giuseppe Pollio, G Westerberg, Bernard Landwehrmeyer, Carla Scali, Brett A. Barbaro, Carol Murphy, Sarah J. Tabrizi
Publikováno v:
Human molecular genetics, vol 23, iss 11
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945f412d35a8fd0b971b3108edc54b4
https://escholarship.org/uc/item/91m8n212
https://escholarship.org/uc/item/91m8n212
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Georg C. Terstappen, Renza Roncarati, Agata Copani, Filippo Caraci, Giovanni Gaviraghi, Giuseppe Pollio, Marco Gianfriddo, Carla Scali, Andrea Caricasole, Ferdinando Nicoletti, Enrica Diodato
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 254-265 (2006)
Expression of the Wnt antagonist Dickkopf-1 (DKK1) is induced during neurodegenerative processes associated with Alzheimer's Disease and brain ischemia. However, little is known about DKK1-mediated effects on neurons. We now describe that, in culture
Autor:
Georg C. Terstappen, Enrica Diodato, Andrea Caricasole, Stefano Gotta, Chiara Lorenzetto, Roberto Raggiaschi
Publikováno v:
Proteomics. 6(3)
Although protein phosphorylation is probably the most studied post-translational modification occurring in cells, the number of proteins, which are the target of this modification, is still largely unknown. Increasing the coverage of the phosphoprote
Autor:
Federica Bottazzoli, Mariagrazia Grilli, Angelo Reggiani, Gianluca Lozza, Patrick M. Downey, Chiara Foglia, Rossella Brusa, Enrica Diodato, Roberta Petrò, Tatiana Asquini
Publikováno v:
Journal of biomolecular screening. 10(8)
Stable and inducible expression of human metabotropic glutamate receptor types 2, 5, and 8 was achieved in HEK293 cells using the ecdysone inducible system. Treatment of the respective cell lines with ponasterone A resulted in time and concentration-