Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Enric I Canela"'
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Autor:
Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 755-783 (2024)
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that
Externí odkaz:
https://doaj.org/article/5c7b69f9446144719e20ce1f4a631547
Autor:
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Publikováno v:
eLife, Vol 9 (2020)
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://doaj.org/article/e29f5e9398d54a2882b616c452b949ae
Autor:
Xavier Viñals, Estefanía Moreno, Laurence Lanfumey, Arnau Cordomí, Antoni Pastor, Rafael de La Torre, Paola Gasperini, Gemma Navarro, Lesley A Howell, Leonardo Pardo, Carmen Lluís, Enric I Canela, Peter J McCormick, Rafael Maldonado, Patricia Robledo
Publikováno v:
PLoS Biology, Vol 13, Iss 7, p e1002194 (2015)
Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents
Externí odkaz:
https://doaj.org/article/669a711f42b14778b2eb8ad7fa286987
Autor:
Sergi eFerre, Cesar eQuiroz, Marco eOrru, Xavier eGuitart, Gema eNavarro, Antonio eCortes, Vicent eCasado, Enric I Canela, Carme eLluis, Rafael eFranco
Publikováno v:
Frontiers in Neuroanatomy, Vol 5 (2011)
A very significant density of adenosine adenosine A2A receptors (A2ARs) is present in the striatum, where they are preferentially localized postsynaptically in striatopallidal medium spiny neurons (MSNs). In this localization A2ARs establish reciproc
Externí odkaz:
https://doaj.org/article/26251834fc144271a077271d6c6d38a2
Autor:
Marco Orru, Jana Bakešová, Marc Brugarolas, César Quiroz, Vahri Beaumont, Steven R Goldberg, Carme Lluís, Antoni Cortés, Rafael Franco, Vicent Casadó, Enric I Canela, Sergi Ferré
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16088 (2011)
Striatal adenosine A(2A) receptors (A(2A)Rs) are highly expressed in medium spiny neurons (MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D(2) receptors (D(2)Rs). A(2A)Rs are also localized presynaptically in cortico-st
Externí odkaz:
https://doaj.org/article/05fec735021e4bc3a36c0dc6e7096f8f
Autor:
Irene B. Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefanía Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric I. Canela, Vicent Casadó, Ismael Galve-Roperh, Ángel Núñez, David Fernández de Sevilla, Ignacio Rodríguez-Crespo, Pablo E. Castillo, Manuel Guzmán
The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R with vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9958c261981712fef7bcb66c20050a
http://hdl.handle.net/2445/198272
http://hdl.handle.net/2445/198272
Publikováno v:
Handbook of Cancer and Immunology ISBN: 9783030809621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237766e26f0d8880f4b036e2f559daee
https://doi.org/10.1007/978-3-030-80962-1_276-1
https://doi.org/10.1007/978-3-030-80962-1_276-1
Autor:
Marta Barrera-Conde, Rafael de la Torre, E.J. Pérez, Arnau Cordomí, Christoph U. Correll, Patricia Robledo, Daniel Guinart, Víctor Pérez, Cristina Fernández-Avilés, Vicent Casadó, Estefanía Moreno, Liliana Galindo, Leonardo Pardo, Enric I. Canela, Aida Cuenca-Royo
Publikováno v:
Schizophr Bull
Schizophrenia (SCZ) has been associated with serotonergic and endocannabinoid systems dysregulation, but difficulty in obtaining in vivo neurological tissue has limited its exploration. We investigated CB1R-5-HT2AR heteromer expression and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a8b812bcb9cc590dd81f1c33eae639
https://doi.org/10.1093/schbul/sbaa038
https://doi.org/10.1093/schbul/sbaa038
Publikováno v:
Current Neuropharmacology
To reach the central nervous system (CNS), drugs must cross the brain-blood barrier and have appropriate pharmacokinetic/dynamic properties. However, in early drug discovery steps, the selection of lead compounds, for example, those targeting G-prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b790a74a5bbc251be6952652d91c50eb
https://doi.org/10.2174/1570159x17666191001144309
https://doi.org/10.2174/1570159x17666191001144309
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Universitat Autònoma de Barcelona
Background Memory consolidation is a process required for the formation of long-term memories. The G-protein-coupled receptor (GPCR) neurokinin-3-receptor (Nk3R) and its interactions with sex hormones seem important for the modulation of fear memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc96737ce9dfb615c3a2488483641508
https://pubmed.ncbi.nlm.nih.gov/35690790
https://pubmed.ncbi.nlm.nih.gov/35690790