Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Enric I, Canela"'
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Autor:
Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 755-783 (2024)
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that
Externí odkaz:
https://doaj.org/article/5c7b69f9446144719e20ce1f4a631547
Autor:
Irene B. Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefanía Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric I. Canela, Vicent Casadó, Ismael Galve-Roperh, Ángel Núñez, David Fernández de Sevilla, Ignacio Rodríguez-Crespo, Pablo E. Castillo, Manuel Guzmán
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R
Externí odkaz:
https://doaj.org/article/de2f897065d34da0933b217db4f53983
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-15 (2022)
Highlights Nk3R antagonism reduces recognition memory consolidation in male mice and increases it in proestrus females. Androgen receptor expression is higher in the CA1 compared to DG, CA3, and the mPFC. Estrogen repcetor α expression is higher in
Externí odkaz:
https://doaj.org/article/03ac6f7938fa4efe8d2b139915b9fef5
Autor:
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Publikováno v:
eLife, Vol 9 (2020)
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://doaj.org/article/e29f5e9398d54a2882b616c452b949ae
Autor:
Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form
Externí odkaz:
https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc
Autor:
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick, Rafael Franco
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (A1-A2AHet), and th
Externí odkaz:
https://doaj.org/article/d4dd4c7d0655450796391030f760eb1d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3661 (2021)
The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with other cellular networks have still not been fully elucidated. Endogenous cannabinoids are molecules w
Externí odkaz:
https://doaj.org/article/bcbc85e9a184411b9bf7dfc73e8b78e5
Publikováno v:
Handbook of Cancer and Immunology ISBN: 9783030809621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237766e26f0d8880f4b036e2f559daee
https://doi.org/10.1007/978-3-030-80962-1_276-1
https://doi.org/10.1007/978-3-030-80962-1_276-1
Autor:
Rafael Franco, David Aguinaga, Irene Reyes, Enric I. Canela, Jaume Lillo, Airi Tarutani, Masato Hasegawa, Anna del Ser-Badia, José A. del Rio, Michael R. Kreutz, Carlos A. Saura, Gemma Navarro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade. Both MAPK- and Ca2+-mediated events are important for both neurotransmission an
Externí odkaz:
https://doaj.org/article/3ca679e6926743efaef20a56da8d2239
Autor:
Gemma Navarro, Katia Varani, Irene Reyes-Resina, Verónica Sánchez de Medina, Rafael Rivas-Santisteban, Carolina Sánchez-Carnerero Callado, Fabrizio Vincenzi, Salvatore Casano, Carlos Ferreiro-Vera, Enric I. Canela, Pier Andrea Borea, Xavier Nadal, Rafael Franco
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. that is attracting pharmacological interest because it is non-psychotropic and is abundant in some industrial hemp varieties. The aim of this work was to investiga
Externí odkaz:
https://doaj.org/article/ee9ed4fa9f5946e5a00bee0ec649a1da