Autophagy-mediated metabolic effects of aspirin

Autor: Castoldi F., Humeau J., Martins I., Lachkar S., Loew D., Dingli F., Durand S., Enot D., Bossut N., Chery A., Aprahamian F., Demont Y., Opolon P., Signolle N., Sauvat A., Semeraro M., Bezu L., Baracco E. E., Vacchelli E., Pol J. G., Levesque S., Bloy N., Sica V., Maiuri M. C., Kroemer G., Pietrocola F.

Publikováno v: Cell Death Discovery, Vol 6, Iss 1, Pp 1-17 (2020)
Cell Death Discovery
Cell Death Discovery, Springer Nature, 2020, 6 (1), ⟨10.1038/s41420-020-00365-0⟩

International audience; Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fa04eeb8082530bede786724be82e06f
https://doaj.org/article/87cf4e0d739f46b498bf36f527c63889

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

Autor: Sica V., Bravo-San Pedro J. M., Izzo V., Pol J., Pierredon S., Enot D., Durand S., Bossut N., Chery A., Souquere S., Pierron G., Vartholomaiou E., Zamzami N., Soussi T., Sauvat A., Mondragon L., Kepp O., Galluzzi L., Martinou J. -C., Hess-Stumpp H., Ziegelbauer K., Kroemer G., Maiuri M. C.

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Cell Reports, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩

Summary: Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9237f157179cf62166902e847f70abc7
https://hal.sorbonne-universite.fr/hal-02317988

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154 - NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations

Autor: Touat, M., Olaussen, K., Sourisseau, T., Friboulet, L., Dorvault, N., Enot, D., Bigot, L., Pontoizeau, C., Mardakheh, F., Thompson, A., Bouillaud, F., Ricchetti, M., Ottolenghi, C., Pierron, G., Sarasin, A., Lombès, A., Ashworth, A., Lord, C., Soria, J.C., Postel-Vinay, S.

Publikováno v: In European Journal of Cancer December 2016 69 Supplement 1:S56-S56