Výsledky vyhledávání - "Enoch N. Gao"

Akademický článek

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti

Externí odkaz: https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887

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Akademický článek

Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu

Externí odkaz: https://doaj.org/article/ee8d0f7b2ad14f48b638c180d558c296

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Acoustic Mist Ionization-Mass Spectrometry: A Comparison to Conventional High-Throughput Screening and Compound Profiling Platforms

Autor: Guofeng Zhang, Enoch N Gao, Melanie Leveridge, Joseph Kozole, Carl A Machutta, Sammy S Datwani, Roland S. Annan, Arseniy M. Belov, Luke Ghislain, Mark F. Bean

Publikováno v: Analytical Chemistry. 92:13847-13854

Drug discovery usually begins with a high-throughput screen (HTS) of thousands to millions of molecules to identify starting points for medicinal chemistry. Conventional HTS platforms require expensive reagents and typically have complex assay format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d069720ff6128efa1dd301a8f59916
https://doi.org/10.1021/acs.analchem.0c02508

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Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite

Autor: David N. Deaton, Enoch N. Gao, Kevin P. Graham, Jeffrey W. Gross, Aaron B. Miller, John M. Strelow

Publikováno v: Bioorganic & Medicinal Chemistry Letters

Graphical abstract Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P1 benzyl moiety led to improvements in ACE2 potency as well as to increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873406abf04c334299a763392af8a8f6
http://europepmc.org/articles/PMC7126659

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