Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Enoch Cobbina"'
Autor:
Bo Zheng, Lucia Wille, Karsten Peppel, David Hagen, Andrew Matteson, Jeffrey Ahlers, James Schaff, Fei Hua, Theresa Yuraszeck, Enoch Cobbina, Joshua F. Apgar, John M. Burke, John Roberts, Raibatak Das
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 696-708 (2021)
Abstract We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produce
Externí odkaz:
https://doaj.org/article/8ba72c23733b4ce5b2853ef6f3a3f586
Autor:
Lucia Wille, Enoch Cobbina, Raibatak Das, John M. Burke, Karsten Peppel, Andrew Matteson, David Robert Hagen, Joshua F. Apgar, John Roberts, Fei Hua, Theresa Yuraszeck, James Schaff, Bo Zheng, Jeffrey Ahlers
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 696-708 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produce a lifelon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f13014a443af0c22d0544d4a93a1f03
https://doi.org/10.1002/psp4.12638
https://doi.org/10.1002/psp4.12638
Autor:
Zhi-Bing You, Enoch Cobbina, Aaron Hammer, Sara L. Deschaine, Kelly M. Abshire, Mehdi Farokhnia, Mary R. Lee, Fatemeh Akhlaghi, Anitha Saravanakumar, Lorenzo Leggio, Carolina L. Haass-Koffler
Publikováno v:
Int J Neuropsychopharmacol
Background Accumulating evidence has established a role for the orexigenic hormone ghrelin in alcohol-seeking behaviors. Accordingly, the ghrelin system may represent a potential pharmacotherapeutic target for alcohol use disorder. Ghrelin modulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cb1dcdfc7573951bd345ef8ccea195
https://doi.org/10.1093/ijnp/pyab004
https://doi.org/10.1093/ijnp/pyab004
Publikováno v:
Clin Pharmacokinet
The ghrelin receptor (GHS-R1a) is a potential target for alcohol use disorders. PF-5190457 is the first inverse agonist of GHS-R1a to progress to clinical development with potential to treat alcohol use disorder. We present a population pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0286bd5eccaf5b1eeabf666b4e7a9fec
https://pubmed.ncbi.nlm.nih.gov/33155163
https://pubmed.ncbi.nlm.nih.gov/33155163
Autor:
April N. Le, Lorenzo Leggio, Lisa A. Farinelli, Enoch Cobbina, Jenica D. Tapocik, Fatemeh Akhlaghi, Mwlod Ghareeb, Mehdi Farokhnia, Alexandra A. Dias, Markus Heilig, Mary R. Lee, Melanie L. Schwandt, Sofia Bouhlal
Publikováno v:
Molecular psychiatry
Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy alcohol drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abdc4187be51af74e0fe7705beece83
https://doi.org/10.1038/s41380-018-0064-y
https://doi.org/10.1038/s41380-018-0064-y
Autor:
Fatemeh Akhlaghi, Enoch Cobbina, Xiaobai Li, Anitha Saravanakumar, Jillian T. Battista, Lisa A. Farinelli, Mehdi Farokhnia, Mary R. Lee, Lorenzo Leggio
Publikováno v:
Neuropharmacology
Both animal and human work suggests that the ghrelin system may be involved in the mechanisms that regulate the development and maintenance of alcohol use disorder. Previously, in a Phase 1b study, we tested pharmacological blockade of the growth hor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a07c335a25f2f92d2e25ac3893985
https://doi.org/10.1016/j.neuropharm.2019.107788
https://doi.org/10.1016/j.neuropharm.2019.107788
Autor:
Isabel Tomaz, João Costa Pessoa, Sameena Mehtab, Eva Enyedi, Isabel Cavaco, Tamás Kiss, Isabel Correia, Gisela Gonçalves, Tamás Jakusch, Enoch Cobbina
Publikováno v:
Journal of the Mexican Chemical Society. 57
In this work the binding of VIVO2+ and VIVO-complexes to serum albumins {human serum albumin (HSA), bovine serum albumin (BSA) and porcine serum albumin (PSA)} are studied using circular dichroism (CD), electron paramagnetic resonance (EPR) and visib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328ba2b052c15c3d96d6801ea1019fdc
https://doi.org/10.29356/jmcs.v57i3.205
https://doi.org/10.29356/jmcs.v57i3.205
Autor:
Enoch Cobbina, Fatemeh Akhlaghi
Publikováno v:
Drug metabolism reviews. 49(2)
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption. Insulin resistance, the metabolic syndrome or type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccca2ac67f37396d709cc6ef597fa2e
https://pubmed.ncbi.nlm.nih.gov/28303724
https://pubmed.ncbi.nlm.nih.gov/28303724