Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Ennio Ongini"'
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 1, Pp 25-32 (2006)
The nitric oxide-releasing derivative of flurbiprofen, NCX 2216, has a safer gastrointestinal profile than the parent drug flurbiprofen and a strong anti-amyloidogenic activity. Here, we show that in primary microglial cultures, in addition to the ex
Externí odkaz:
https://doaj.org/article/7076f429cf2a4816892636366c4e1a73
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35196 (2012)
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certa
Externí odkaz:
https://doaj.org/article/47cd3880c38646378f5f637668b5f5dc
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49350 (2012)
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised
Externí odkaz:
https://doaj.org/article/99f5b2665d23452f9de30f2edad33b36
Autor:
Daniela Miglietta, Roberto Bottinelli, Ennio Ongini, Angela Monopoli, Anna Mascaro, Giuseppe D'Antona
Publikováno v:
Muscle & Nerve. 47:72-80
Introduction: Myopathy is the most common side effect of statins. Because nitric oxide (NO) has a key role in regulating skeletal muscle function, we studied whether the NO-donating atorvastatin NCX 6560 could show a better profile on skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5db3b3362c155af9b33b2938df4c5b
https://doi.org/10.1002/mus.23465
https://doi.org/10.1002/mus.23465
Autor:
David Gale, Francesco Impagnatiello, Wesley K. M. Chong, Samantha Carreiro, Minerva R. Batugo, Ganesh Prasanna, Ennio Ongini, Massimiliano Guzzetta, Achim H.-P. Krauss, S. Brambilla, Valentina Borghi, Valerio Chiroli
Publikováno v:
Experimental Eye Research. 93:243-249
The IOP lowering effects of NCX 139, a new chemical entity comprising latanoprost amide and a NO-donating moiety, were compared to those of the respective des-nitro analog in in vitro assays and in rabbit and dog models of ocular hypertension. The NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbccd7a68b849e4e254a0d5633940728
https://doi.org/10.1016/j.exer.2011.02.006
https://doi.org/10.1016/j.exer.2011.02.006
Autor:
Gmvu Mangialardi, Ennio Ongini, Orazio Fortunato, Costanza Emanueli, Gaia Spinetti, Angela Monopoli, Paolo Madeddu
Publikováno v:
British Journal of Pharmacology. 164:570-583
BACKGROUND AND PURPOSE Statins, a major component of the prevention of cardiovascular disease, aid progenitor cell functions in vivo and in vitro. Statins bearing a NO-releasing moiety were developed for their enhanced anti-inflammatory/anti-thrombot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec88e3d3eff567d11bd390030093c32
https://doi.org/10.1111/j.1476-5381.2011.01423.x
https://doi.org/10.1111/j.1476-5381.2011.01423.x
Autor:
Daniela Miglietta, Hillary Thompson, Francesco Impagnatiello, Ennio Ongini, Bahram Khoobehi, Daniela Ronchetti, Valerio Chiroli
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 27:115-121
Hypoxia of the retina and optic nerve head (ONH) is believed to be pivotal in the development of ocular vascular disorders, including diabetic macular edema (DME). Glucocorticoids are among the most effective agents for the treatment of back of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43783874593f26bd83621cc70c4d61fd
https://doi.org/10.1089/jop.2010.0150
https://doi.org/10.1089/jop.2010.0150
Autor:
Minerva R. Batugo, Valerio Chiroli, Ganesh Prasanna, Valentina Borghi, Elena Bastia, Ennio Ongini, Liu Jia, Achim Hans-Peter Krauss, Francesco Impagnatiello, David J. Kucera, Massimiliano Guzzetta, Carol B. Toris, David Gale, Wesley K. M. Chong, Samantha Carreiro
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 26:125-132
Nitric oxide (NO) is involved in a variety of physiological processes including ocular aqueous humor dynamics by targeting mechanisms that are complementary to those of prostaglandins. Here, we have characterized a newly synthesized compound, NCX 125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb206a9e50a5682f368070807694c6a
https://doi.org/10.1089/jop.2009.0120
https://doi.org/10.1089/jop.2009.0120
Autor:
Monica Donnola, Antonella Di Stilo, Loretta Lazzarato, Ennio Ongini, Elisabetta Marini, Barbara Rolando, Alberto Gasco, Stefano Biondi, Clara Cena, Roberta Fruttero, Konstantin Chegaev
Publikováno v:
Journal of Medicinal Chemistry. 52:5058-5068
A series of (nitrooxyacyloxy)methyl esters of aspirin were synthesized and evaluated as new NO-donor aspirins. Different amounts of aspirin were released in serum from these products according to the nature of nitrooxyacyloxy moiety present. In the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfc7440cb4adc90452333e53eb33a52
https://doi.org/10.1021/jm900587h
https://doi.org/10.1021/jm900587h
Publikováno v:
Acta Pharmacologica et Toxicologica. 45:145-151
Reproductive and teratological studies were undertaken with netilmicin (Sch 20569), a new semisynthetic aminolgycoside antibiotic structurally related to sisomicin. The administration of 32 and 80 mg/kg/day, by the intramuscular route, in the rat pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a848a57d7b2736e1746bb478d9d27e
https://doi.org/10.1111/j.1600-0773.1979.tb02374.x
https://doi.org/10.1111/j.1600-0773.1979.tb02374.x