Engrailed‐1 Promotes Pancreatic Cancer Metastasis

Autor: Jihao Xu, Jae‐Seok Roe, EunJung Lee, Claudia Tonelli, Keely Y. Ji, Omar W. Younis, Tim D.D. Somervile, Melissa Yao, Joseph P. Milazzo, Herve Tiriac, Anna M. Kolarzyk, Esak Lee, Jean L. Grem, Audrey J. Lazenby, James A. Grunkemeyer, Michael A. Hollingsworth, Paul M. Grandgenett, Alexander D. Borowsky, Youngkyu Park, Christopher R. Vakoc, David A. Tuveson, Chang‐Il Hwang

Publikováno v: Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)

Abstract Engrailed‐1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrant

Externí odkaz: https://doaj.org/article/fa247bd53d254f95b68bf57810402255

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Retrotransposons as a Source of DNA Damage in Neurodegeneration

Autor: Eugenie Peze-Heidsieck, Tom Bonnifet, Rania Znaidi, Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Rajiv L. Joshi, Julia Fuchs

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2022)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, 2022, 13, ⟨10.3389/fnagi.2021.786897⟩

International audience; The etiology of aging-associated neurodegenerative diseases (NDs), such as Parkinson's disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment is available. Age is the major risk factor for P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f8f82b9c12450167d6a6a3aff49ff8
https://www.frontiersin.org/articles/10.3389/fnagi.2021.786897/full

GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action

Autor: Andreas Schober, Heike Peterziel, Christopher S. von Bartheld, Horst Simon, Kerstin Krieglstein, Klaus Unsicker

Publikováno v: Neurobiology of Disease, Vol 25, Iss 2, Pp 378-391 (2007)

GDNF is a potent neurotrophic factor for nigrostriatal dopaminergic neurons in vitro and in animal models of Parkinson's disease (PD), but has largely failed when tested in therapeutic applications in human PD. We report here that GDNF requires trans

Externí odkaz: https://doaj.org/article/382c1449dac84147b16953360e413849

Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration

Autor: Angela P. Taylor

Evidence for a cerebellar role during cardiopulmonary challenges has long been established, but investigation into cerebellar involvement in eupneic breathing has been inconclusive. Given the view of the cerebellum (CRB) as a temporally coordinating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::275312cb03e068a504a4bb9f0b134106
https://doi.org/10.21007/etd.cghs.2020.0528