Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications.

Autor: Wireko, Andrew Awuah¹ (AUTHOR) andyvans36@yahoo.com, Ben-Jaafar, Adam² (AUTHOR), Kong, Jonathan Sing Huk³ (AUTHOR), Mannan, Krishitha Meenu⁴ (AUTHOR), Sanker, Vivek⁵ (AUTHOR), Rosenke, Sophie-Liliane⁶ (AUTHOR), Boye, Allswell Naa Adjeley⁷ (AUTHOR), Nkrumah-Boateng, Princess Afia⁷ (AUTHOR), Poornaselvan, Jeisun² (AUTHOR), Shah, Muhammad Hamza⁴ (AUTHOR), Abdul-Rahman, Toufik¹ (AUTHOR), Atallah, Oday⁸ (AUTHOR)

Publikováno v: Molecular Brain. 11/20/2024, Vol. 17 Issue 1, p1-22. 22p.

Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.

Autor: Cheng D; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA., Han D, Gao W, Jing Q, Jiang J, Wan Y, Englund NP, Tuntland T, Wu X, Pan S

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Nov 01; Vol. 22 (21), pp. 6573-6. Date of Electronic Publication: 2012 Sep 13.

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.

Autor: Pan S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Wu X; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Jiang J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Gao W; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Wan Y; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Cheng D; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Han D; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Liu J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Englund NP; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Wang Y; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Peukert S; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Miller-Moslin K; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Yuan J; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Guo R; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Matsumoto M; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Vattay A; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Jiang Y; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Tsao J; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Sun F; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Pferdekamper AC; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Dodd S; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Tuntland T; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121., Maniara W; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Kelleher JF 3rd; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Yao YM; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Warmuth M; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Williams J; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139., Dorsch M; Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Mar 16; Vol. 1 (3), pp. 130-4. Date of Electronic Publication: 2010 Mar 16 (Print Publication: 2010).

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives.

Autor: Song, Jia^1,2 (AUTHOR), Ge, Yuexin^1,2 (AUTHOR), Sun, Xiaoyu^1,2 (AUTHOR), Guan, Qiutong^1,2 (AUTHOR), Gong, Shiqiang^1,2 (AUTHOR), Wei, Minjie^1,2,3 (AUTHOR), Niu, Jumin⁴ (AUTHOR) niujumin@163.com, Zhao, Lin^1,2 (AUTHOR) lzhao@cmu.edu.cn

Publikováno v: Molecular Cancer. 5/17/2022, Vol. 21 Issue 1, p1-16. 16p.

P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression.

Autor: Li Q; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Liu Y; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Wu J; Department of pathology, College of Basic Medicine, Molecular Medicine Diagnostic and Testing Center, Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 400016, China., Zhu Z; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Fan J; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Zhai L; Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China., Wang Z; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Du G; Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China., Zhang L; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Hu J; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Ma DK; Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA., Liu JO; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Huang H; Department of Cell Biology, and Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China., Tan M; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Dang Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China. yjdang@cqmu.edu.cn., Jiang W; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. jiangw@fudan.edu.cn.

Publikováno v: Leukemia [Leukemia] 2024 Aug; Vol. 38 (8), pp. 1751-1763. Date of Electronic Publication: 2024 Jun 22.