KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development.

Autor: Tinsley SL; Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Chianis ERD; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Shelley RA; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Mall GK; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Dhiman A; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Baral G; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Kothandaraman H; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA., Thoma MC; Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA., English IA; Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA., Daniel CJ; Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA., Acosta LCS; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Solorio L; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Atallah Lanman N; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA., Pasca di Magliano M; Department of Internal Medicine, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA., Narla G; Department of Internal Medicine, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA., Dykhuizen EC; Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA., Sears RC; Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health and Sciences University, Portland, OR, USA., Allen-Petersen BL; Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu.

Publikováno v: Oncogene [Oncogene] 2024 Dec; Vol. 43 (50), pp. 3673-3687. Date of Electronic Publication: 2024 Oct 23.

Deconstructing Pancreatic Adenocarcinoma by Targeting the Conductor, MYC.

Autor: English IA; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon., Sears RC; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon. searsr@ohsu.edu.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Brenden Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, Oregon.

Publikováno v: Cancer discovery [Cancer Discov] 2020 Apr; Vol. 10 (4), pp. 495-497.