Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer.

Autor: Lemberger U; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Ernhofer B; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Krieger S; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria., Bruchbacher A; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Oszwald A; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria., Laukhtina E; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Haitl A; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria., Hassler MR; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Englinger B; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Center for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Compérat E; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria., Shariat SF; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Urology, Weill Cornell Medical College, New York, NY, USA.; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czechia.; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan.

Publikováno v: European urology open science [Eur Urol Open Sci] 2024 Dec 05; Vol. 71, pp. 38-48. Date of Electronic Publication: 2024 Dec 05 (Print Publication: 2025).

The tyrosine kinase inhibitor Nintedanib induces lysosomal dysfunctionality: Role of protonation-dependent crystallization processes.

Autor: Mosca E; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Federa A; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria; Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Straße 40-42, 1090, Vienna, Austria., Pirker C; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Schosserer M; Center of Pathobiochemistry and Genetics, Medical University of Vienna, Währinger Straße 10, 1090, Vienna, Austria., Liendl L; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, 1190, Vienna, Austria., Eckhard M; Center for Anatomy and Cell Biology, Cell and Developmental Biology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria., Sombke A; Center for Anatomy and Cell Biology, Cell and Developmental Biology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria., Dömötör O; Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, H-6720, Dóm Tér 7-8, Szeged, Hungary., Kirchhofer D; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Timelthaler G; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Baier D; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', Vienna, 1090, Austria., Gurschka P; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Gabler L; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Reithofer M; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria., Chin JM; Department of Functional Materials and Catalysis, Währinger Straße 42, 1090, Vienna, Austria., Elsayad K; Division of Anatomy, Center of Anatomy and Cell Biology, Medical University of Vienna, Währinger Straße 13, 1090, Vienna, Austria., Englinger B; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Urology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Tahir A; Division of Pharmacognosy, Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria; Section of Biomedical Sciences, Department of Health Sciences, FH Campus Wien, University of Applied Sciences, Favoritenstraße 226, 1100, Vienna, Austria., Kowol CR; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria. Electronic address: christian.kowol@univie.ac.at., Berger W; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria. Electronic address: walter.berger@meduniwien.ac.at.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2024 Nov 01; Vol. 403, pp. 111243. Date of Electronic Publication: 2024 Sep 14.

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant.

Autor: Liu I; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, 10117 Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, 10117 Berlin, Germany., Alencastro Veiga Cruzeiro G; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bjerke L; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Rogers RF; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Grabovska Y; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Beck A; Center for Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany., Mackay A; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Barron T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Hack OA; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Quezada MA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Molinari V; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Shaw ML; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Perez-Somarriba M; Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, Surrey SM2 5 NG, UK., Temelso S; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK., Raynaud F; Division of Cancer Therapeutics, The Institute of Cancer Research, London SW7 3RK, UK., Ruddle R; Division of Cancer Therapeutics, The Institute of Cancer Research, London SW7 3RK, UK., Panditharatna E; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Englinger B; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria; Center for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Mire HM; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Jiang L; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Nascimento A; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., LaBelle J; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Haase R; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Rozowsky J; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Neyazi S; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Baumgartner AC; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Castellani S; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Hoffman SE; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Cameron A; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Morrow M; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Pericoli G; Department of Onco-haematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, 00165 Rome, Italy., Madlener S; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Mayr L; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Dorfer C; Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria., Geyeregger R; Clinical Cell Biology, Children's Cancer Research Institute (CCRI), Vienna 1090, Austria., Rota C; Department of Neurobiology, Harvard Medical School, Boston, MA 02215, USA., Ricken G; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna 1090, Austria., Ligon KL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA., Alexandrescu S; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA., Cartaxo RT; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA., Lau B; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA., Uphadhyaya S; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA., Koschmann C; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA., Braun E; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden., Danan-Gotthold M; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden., Hu L; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden., Siletti K; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden., Sundström E; Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17177 Stockholm, Sweden., Hodge R; Allen Institute for Brain Science, Seattle, WA 98109, USA., Lein E; Allen Institute for Brain Science, Seattle, WA 98109, USA., Agnihotri S; Departments of Neurosurgery and Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Eisenstat DD; Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia., Stapleton S; Department of Neurosurgery, St George's Hospital NHS Trust, London SW17 0QT, UK., King A; Department of Neuropathology, King's College Hospital NHS Trust, London SE5 9RS, UK., Bleil C; Department of Neurosurgery, King's College Hospital NHS Trust, London SE5 9RS, UK., Mastronuzzi A; Department of Onco-haematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, 00165 Rome, Italy., Cole KA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Waanders AJ; Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA., Montero Carcaboso A; Laboratory of Molecular Oncology, Hospital Sant Joan de Déu, 08950 Barcelona, Spain., Schüller U; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Hargrave D; University College London Great Ormond Street Institute for Child Health, London WC1N 1EH, UK., Vinci M; Department of Onco-haematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, 00165 Rome, Italy., Carceller F; Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, Surrey SM2 5 NG, UK; Division of Clinical Studies, The Institute of Cancer Research, London SW7 3RK, UK., Haberler C; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna 1090, Austria., Slavc I; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Linnarsson S; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden., Gojo J; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria., Monje M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford, CA, USA., Jones C; Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey SM2 5 NG, UK. Electronic address: chris.jones@icr.ac.uk., Filbin MG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: mariella.filbin@childrens.harvard.edu.

Publikováno v: Cancer cell [Cancer Cell] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27.

Preclinical models for bladder cancer therapy research.

Autor: Ertl I; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Shariat SF; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Urology, Weill Cornell Medical College, New York, New York.; Department of Urology, University of Texas Southwestern, Dallas, Texas, USA.; Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic.; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria.; Research Center for Evidence Medicine, Urology Department Tabriz University of Medical Sciences, Tabriz, Iran.; Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan., Berger W; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Englinger B; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Center for Cancer Research, Medical University of Vienna, Vienna, Austria.

Publikováno v: Current opinion in urology [Curr Opin Urol] 2024 Jul 01; Vol. 34 (4), pp. 244-250. Date of Electronic Publication: 2024 Apr 16.

Advances in preclinical assessment of therapeutic targets for bladder cancer precision medicine.

Autor: Nössing C; Department of Urology, Comprehensive Cancer Center., Herek P; Department of Urology, Comprehensive Cancer Center.; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Austria., Shariat SF; Department of Urology, Comprehensive Cancer Center.; Department of Urology, Weill Cornell Medical College, New York, New York.; Department of Urology, University of Texas Southwestern, Dallas, Texas, USA.; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; Institute for Urology, University of Jordan, Amman, Jordan.; Research center for Evidence Medicine, Urology Department, Tabriz University of Medical Sciences, Tabriz, Iran.; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria., Berger W; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Austria., Englinger B; Department of Urology, Comprehensive Cancer Center.; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Austria.

Publikováno v: Current opinion in urology [Curr Opin Urol] 2024 Jul 01; Vol. 34 (4), pp. 251-257. Date of Electronic Publication: 2024 Apr 10.