Prenatal administration of Betamethasone causes changes in the T cell receptor repertoire influencing Development of autoimmunity

Autor: Gieras, A, Gehbauer, C, Perna-Barrull, D, Engler, JB, Diepenbruck, I, Glau, L, Joosse, SA, Kersten, N, Klinge, S, Mittrucker, HW, Friese, MA, Vives-Pi, M, Tolosa, E

Publikováno v: Frontiers in Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocortic

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https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6013

Ferroptosis in health and disease.

Autor: Berndt C; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Amen VS; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Ayton S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia., Barayeu U; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany., Bayir H; Department of Pediatrics, Columbia University, New York City, NY, USA., Bebber CM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Birsoy K; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Böttcher JP; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Brabletz S; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brabletz T; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brown AR; Department of Biological Sciences, Columbia University, New York City, NY, USA., Brüne B; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Bulli G; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Chen Q; College of Life Sciences, Nankai University, Tianjin, China., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Dick TP; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Distéfano A; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Esser-von Bieren J; Department of Immunobiology, Université de Lausanne, Switzerland., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Fuhrmann DC; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., García-Sáez AJ; Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany., Garbowicz K; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Götz M; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany., Gu W; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Hammerich L; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Hassannia B; Department of Biomedical Sciences, University of Antwerp, Belgium., Jiang X; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Jeridi A; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL)., Kang YP; College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea., Kagan VE; School of Public Health, University of Pittsburgh, PA, USA., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Kotschi S; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Lei P; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Le Tertre M; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Lev S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Liang D; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA., Lohr C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Lorenz S; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Methner A; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Michalke B; Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany., Milton AV; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Min J; School of Medicine, Zhejiang University, Hangzhou, China., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Müller S; Cellular and Chemical Biology, Institut Curie, Paris, France., Motohashi H; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Muckenthaler MU; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Murakami S; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Olzmann JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Pagnussat G; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Pan Z; School of Life Sciences, Westlake University, Hangzhou, China., Papagiannakopoulos T; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Pedrera Puentes L; Institute for Genetics, CECAD, University of Cologne, Germany., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Rodriguez R; Cellular and Chemical Biology, Institut Curie, Paris, France., Saito Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Schmidt F; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Schmitt C; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Schulze A; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., Schwab A; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Schwantes A; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Soula M; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Spitzlberger B; Department of Immunobiology, Université de Lausanne, Switzerland; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany., Stockwell BR; Department of Biological Sciences, Columbia University, New York City, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA., Thewes L; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Thorn-Seshold O; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Toyokuni S; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Nagoya, Japan., Tonnus W; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Vandenabeele P; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vanden Berghe T; Department of Biomedical Sciences, University of Antwerp, Belgium; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Venkataramani V; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Germany., Vogel FCE; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., von Karstedt S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Wang F; School of Medicine, Zhejiang University, Hangzhou, China., Westermann F; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Wientjens C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wilhelm C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wölk M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Wu K; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Yang X; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Yu F; College of Life Sciences, Nankai University, Tianjin, China., Zou Y; School of Life Sciences, Westlake University, Hangzhou, China; Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany. Electronic address: marcus.conrad@helmholtz-muenchen.de.

Publikováno v: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103211. Date of Electronic Publication: 2024 May 30.

Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis.

Autor: Winschel I; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Willing A; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Walkenhorst M; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meurs N; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Binkle-Ladisch L; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Woo MS; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pfeffer LK; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sonner JK; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Borgmeyer U; Center of Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hagen SH; Research Department Virus Immunology, Leibniz Institute of Virology, Hamburg, Germany., Grünhagel B; Research Department Virus Immunology, Leibniz Institute of Virology, Hamburg, Germany., Claussen JM; Research Department Virus Immunology, Leibniz Institute of Virology, Hamburg, Germany., Altfeld M; Research Department Virus Immunology, Leibniz Institute of Virology, Hamburg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.

Publikováno v: Biology of sex differences [Biol Sex Differ] 2024 May 15; Vol. 15 (1), pp. 41. Date of Electronic Publication: 2024 May 15.

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells.

Autor: Woo MS; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Ufer F; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Sonner JK; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Belkacemi A; Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany.; Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany., Tintelnot J; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Sáez PJ; Institut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, F-75005, Paris, France.; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Krieg PF; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Mayer C; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Binkle-Ladisch L; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Bauer S; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Kursawe N; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Vieira V; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Mannebach S; Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany., Freichel M; Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 69120 Heidelberg, Germany., Flockerzi V; Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany., Vargas P; Institut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, F-75005, Paris, France.; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

Publikováno v: Science advances [Sci Adv] 2023 Sep 22; Vol. 9 (38), pp. eadh1653. Date of Electronic Publication: 2023 Sep 20.

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.

Autor: Rothammer N; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany., Woo MS; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany., Bauer S; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany., Binkle-Ladisch L; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany., Di Liberto G; Department of Pathology and Immunology, Division of Clinical Pathology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Egervari K; Department of Pathology and Immunology, Division of Clinical Pathology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Wagner I; Department of Pathology and Immunology, Division of Clinical Pathology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Haferkamp U; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany., Pless O; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany., Merkler D; Department of Pathology and Immunology, Division of Clinical Pathology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Engler JB; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany., Friese MA; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany.

Publikováno v: Science advances [Sci Adv] 2022 Aug 05; Vol. 8 (31), pp. eabm5500. Date of Electronic Publication: 2022 Aug 05.