Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Engineering Science of Biological Systems"'
Autor:
Varsha Sitaraman, Surya Karunakaran, Jessica Choi, Sowmya Rajendran, Molly Hunter, Jeremy Minshull, Maggie Lee, Rebecca Wang, Nicolay V. Kulikov, Ferenc Boldog, Calvin Tang, Lynn Webster, Divya Vavilala, Sowmya Balasubramanian, Harpreet Kaur
Publikováno v:
Biotechnology and Bioengineering
The development of highly productive, genetically stable manufacturing cell lines is on the critical path to IND filing for protein‐based biologic drugs. Here, we describe the Leap‐In Transposase® platform, a novel transposon‐based mammalian (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24d082224fb964013c4487cc667cd8d
http://europepmc.org/articles/PMC8252637
http://europepmc.org/articles/PMC8252637
Autor:
Xu, Peng
Publikováno v:
Biotechnology and Bioengineering
Microbial consortium is a complex adaptive system with higher‐order dynamic characteristics that are not present by individual members. To accurately predict the social interactions, we formulate a set of unstructured kinetic models to quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbe9d9adfe2b01dfc0276da4c1d3aef
https://doi.org/10.1002/bit.27562
https://doi.org/10.1002/bit.27562
Autor:
Jiang, Hanxiao, Horwitz, Andrew A., Wright, Chapman, Tai, Anna, Znameroski, Elizabeth A., Tsegaye, Yoseph, Warbington, Hailley, Bower, Benjamin S., Alves, Christina, Co, Carl, Jonnalagadda, Kanvasri, Platt, Darren, Walter, Jessica M., Natarajan, Venkatesh, Ubersax, Jeffrey A., Cherry, Joel R., Love, J. Christopher
Publikováno v:
Biotechnology and Bioengineering
For commercial protein therapeutics, Chinese hamster ovary (CHO) cells have an established history of safety, proven capability to express a wide range of therapeutic proteins and high volumetric productivities. Expanding global markets for therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3cd71ffa137ce571ec068e7e0dd8ec1
http://europepmc.org/articles/PMC6836876
http://europepmc.org/articles/PMC6836876
Publikováno v:
Biotechnology and Bioengineering, 118(4)
Biotechnology and Bioengineering
Biotechnology and Bioengineering
This study explores the relation between biomass‐specific succinic acid (SA) production rate and specific growth rate of an engineered industrial strain of Saccharomyces cerevisiae, with the aim to investigate the extent to which growth and product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974bf88a109ed480b7dd63da24b5be07
http://resolver.tudelft.nl/uuid:d162d3e1-ba11-4152-a544-704bbbf92436
http://resolver.tudelft.nl/uuid:d162d3e1-ba11-4152-a544-704bbbf92436
Publikováno v:
Biotechnology and Bioengineering, 118 (2021)(3)
Biotechnology and Bioengineering
Biotechnology and Bioengineering
Biofilm and granular sludge processes depend on diffusion of substrates. Despite their importance for the kinetic description of biofilm reactors, biofilm diffusion coefficients reported in literature vary greatly. The aim of this simulation study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b7866f8611a862e5e9759987373ff2
https://doi.org/10.5194/biofilms9-85
https://doi.org/10.5194/biofilms9-85
Autor:
Sai Rashmika Velugula-Yellela, David N. Powers, Ryan J. Graham, Nicholas Trunfio, Erica J. Fratz‐Berilla, Adil Mohammad, Cyrus Agarabi, Talia Faison, Casey Kohnhorst, Phillip Angart
Publikováno v:
Biotechnology and Bioengineering
A mycoplasma contamination event in a biomanufacturing facility can result in costly cleanups and potential drug shortages. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and penetrate the standard 0.2‐µm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c901167f2fdf46a3630e46a690b4ffc6
https://pubmed.ncbi.nlm.nih.gov/32436993
https://pubmed.ncbi.nlm.nih.gov/32436993
Autor:
Joseph D. Seymour, Lenno van den Berg, Merle de Kreuk, Sarah L. Codd, Catherine M. Kirkland, Mark C.M. van Loosdrecht
Publikováno v:
Biotechnology and Bioengineering
Biotechnology and Bioengineering, 117(12)
Biotechnology and Bioengineering, 117(12)
Aerobic granular sludge (AGS) technology allows simultaneous nitrogen, phosphorus, and carbon removal in compact wastewater treatment processes. To operate, design, and model AGS reactors, it is essential to properly understand the diffusive transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99661cb8776d0dc4b06a236197e12cbc
https://doi.org/10.1002/bit.27522
https://doi.org/10.1002/bit.27522
Publikováno v:
Biotechnology and Bioengineering
Cells cultured on micropatterns exhibit a chiral orientation, which may underlie the development of left–right asymmetry in tissue microarchitectures. To investigate this phenomenon, fluorescence staining of nuclei has been used to reveal such orie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8607d4c54693e1d086820332cb17f
http://europepmc.org/articles/PMC6220999
http://europepmc.org/articles/PMC6220999
Autor:
Graham Christie, Ke Xu Zhou, Eamon Wan, D. Ian Wilson, Adrian M. Ionescu, Yeuk N. Ho, Crispin H. W. Barnes
Publikováno v:
Biotechnology and Bioengineering
Spores of Bacillus megaterium, Bacillus cereus, and Bacillus subtilis were found to exhibit intrinsic paramagnetic properties as a result of the accumulation of manganese ions. All three Bacillus species displayed strong yet distinctive magnetic prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaf1fec768b76099669bf64eba3324d
https://www.repository.cam.ac.uk/handle/1810/271822
https://www.repository.cam.ac.uk/handle/1810/271822
Publikováno v:
Biotechnology and Bioengineering
Recombinant protein expression often presents a bottleneck for the production of proteins for use in many areas of animal‐cell biotechnology. Difficult‐to‐express proteins require the generation of numerous expression constructs, where popular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad166901e486afc2ea28195ac96b758
https://pubmed.ncbi.nlm.nih.gov/26913471
https://pubmed.ncbi.nlm.nih.gov/26913471