Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy

Autor: Gilissen, Lennard P.L., Wong, Dennis R., Engels, Leopold G.J.B., Bierau, Jörgen, Bakker, Jaap A., Paulussen, Aimée D.C., Romberg-Camps, Mariëlle J., Stronkhorst, Arnold, Bus, Paul, Bos, Laurens P., Hooymans, Piet M., Stockbrügger, Reinhold W., Neef, Cees, Masclee, Ad A.M.

Publikováno v: In Journal of Crohn's and Colitis July 2012 6(6):698-707

Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease

Autor: Wong, Dennis R, Coenen, Marieke J H, Vermeulen, Sita H, Derijks, Luc J J, van Marrewijk, Corine J, Klungel, Olaf H, Scheffer, Hans, Franke, Barbara, Guchelaar, Henk-Jan, de Jong, Dirk J, Engels, Leopold G J B, Verbeek, André L M, Hooymans, Piet M, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology

Publikováno v: Journal of Crohn's and Colitis, 11, 2, pp. 175-184
Journal of Crohn's & Colitis, 11(2), 175. Oxford University Press
Journal of Crohn's and Colitis, 11, 175-184
Journal of Crohn's and Colitis, 11(2), 175-184

Background and aims: Only a quarter of thiopurine-induced myelotoxicity in inflammatory bowel disease [IBD] patients is related to thiopurine S-methyltransferase deficiency. We determined the predictive value of 6-thioguanine nucleotide [6-TGN] and 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8601b535166079f25ebc0ddfa9f608c
https://doi.org/10.1093/ecco-jcc/jjw130

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Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study

Autor: Keszthelyi, Daniel, Jansen, Sita V, Schouten, Gerben A, De Kort, Sander, Scholtes, Brian, Engels, Leopold GJB, Masclee, Ad A.

Publikováno v: Alimentary Pharmacology and Therapeutics
Alimentary Pharmacology and Therapeutics, Wiley, 2010, 32 (9), pp.1124. ⟨10.1111/j.1365-2036.2010.04453.x⟩

International audience; Background: Microscopic colitis (MC) causes chronic watery diarrhea. Recent studies have suggested an etiological role for various medications, including proton pump inhibitors, in the pathogenesis of MC. Aim: To determine whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______212::65964adb6e1286db4f8060e3710a2648
https://hal.archives-ouvertes.fr/hal-00576167

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