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pro vyhledávání: '"Engelhardt KR"'
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Akademický článek
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Akademický článek
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Autor:
Chen R; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Lukianova E; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., van der Loeff IS; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK., Spegarova JS; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Willet JDP; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., James KD; Institute of Immunology and Immunotherapy, University of Birmingham. B15 2TT Birmingham, UK., Ryder EJ; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Griffin H; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., IJspeert H; Department of Immunology, Erasmus University Medical Center, Rotterdam 3000 CA, Netherlands., Gajbhiye A; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Lamoliatte F; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Marin-Rubio JL; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Woodbine L; Genome Damage and Stability Centre, University of Sussex, BN1 9RQ Brighton, UK., Lemos H; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Swan DJ; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Pintar V; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Sayes K; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Ruiz-Morales ER; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Eastham S; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Dixon D; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Prete M; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Prigmore E; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Jeggo P; Genome Damage and Stability Centre, University of Sussex, BN1 9RQ Brighton, UK., Boyes J; Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, UK., Mellor A; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Huang L; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., van der Burg M; Department of Immunology, Erasmus University Medical Center, Rotterdam 3000 CA, Netherlands., Engelhardt KR; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Stray-Pedersen A; Norwegian National Unit for Newborn Screening, Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo 0424, Norway., Erichsen HC; Division of Pediatric and Adolescent Medicine, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo 0424, Norway., Gennery AR; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK., Trost M; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Adams DJ; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Anderson G; Institute of Immunology and Immunotherapy, University of Birmingham. B15 2TT Birmingham, UK., Lorenc A; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Trynka G; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK.; Open Targets, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Hambleton S; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK.
Publikováno v:
Science immunology [Sci Immunol] 2024 May 24; Vol. 9 (95), pp. eade5705. Date of Electronic Publication: 2024 May 24.
Autor:
Tsilifis C; Paediatric Haematopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Spegarova JS; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Good R; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Griffin H; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Engelhardt KR; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Graham S; Faculty of Medical Sciences, Medical School, Newcastle University, Newcastle Upon Tyne, UK., Hughes S; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Arkwright PD; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Hambleton S; Paediatric Haematopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Gennery AR; Paediatric Haematopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK. andrew.gennery@newcastle.ac.uk.; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. andrew.gennery@newcastle.ac.uk.
Publikováno v:
Journal of clinical immunology [J Clin Immunol] 2024 Apr 10; Vol. 44 (4), pp. 98. Date of Electronic Publication: 2024 Apr 10.
Autor:
van der Made CI; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Kersten S; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Chorin O; Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Engelhardt KR; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Ramakrishnan G; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Griffin H; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Schim van der Loeff I; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK; Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Venselaar H; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Rothschild AR; Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Segev M; Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel., Schuurs-Hoeijmakers JHM; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Mantere T; Laboratory of Cancer Genetics and Tumor Biology, Research Unit of Translational Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland., Essers R; Maastricht University Medical Centre MUMC+, Department of Clinical Genetics, Maastricht, the Netherlands; GROW School for Oncology and Developmental Biology, Department of Genetics and Cell Biology, Maastricht, the Netherlands., Esteki MZ; Maastricht University Medical Centre MUMC+, Department of Clinical Genetics, Maastricht, the Netherlands; GROW School for Oncology and Developmental Biology, Department of Genetics and Cell Biology, Maastricht, the Netherlands., Avital AL; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Loo PS; Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Simons A; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Pfundt R; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Warris A; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK., Seyger MM; Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands., van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Slatter MA; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK; Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Flood T; Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Gennery AR; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK; Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Simon AJ; Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel., Lev A; Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel., Frizinsky S; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel., Barel O; The Wohl Institute for Translational Medicine and Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., van der Burg M; Department of Pediatrics, Laboratory for Pediatric Immunology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands., Somech R; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel., Hambleton S; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK; Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Henriet SSV; Department of Pediatric Infectious Diseases and Immunology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands., Hoischen A; Department of Human Genetics, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands. Electronic address: alexander.hoischen@radboudumc.nl.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2024 Apr 04; Vol. 111 (4), pp. 791-804. Date of Electronic Publication: 2024 Mar 18.
Autor:
Block J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Rashkova C; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Castanon I; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Zoghi S; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Platon J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Ardy RC; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Fujiwara M; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Chaves B; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Schoppmeyer R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., van der Made CI; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Jimenez Heredia R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Harms FL; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Alavi S; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Alsina L; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Sanchez Moreno P; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Ávila Polo R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Cabrera-Pérez R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Kostel Bal S; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Pfajfer L; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Ransmayr B; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Mautner AK; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Kondo R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Tinnacher A; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Caldera M; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Schuster M; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Domínguez Conde C; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Platzer R; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Salzer E; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Boyer T; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Brunner HG; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Nooitgedagt-Frons JE; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Iglesias E; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Deyà-Martinez A; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Camacho-Lovillo M; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Menche J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Bock C; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Huppa JB; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Pickl WF; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Distel M; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Yoder JA; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Traver D; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Engelhardt KR; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Linden T; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Kager L; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Hannich JT; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Hoischen A; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Hambleton S; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Illsinger S; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Da Costa L; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Kutsche K; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Chavoshzadeh Z; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., van Buul JD; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Antón J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Calzada-Hernández J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Neth O; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Viaud J; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Nishikimi A; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Dupré L; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)., Boztug K; From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.), and the Departments of Pediatrics and Adolescent Medicine (C.R., R.J.H., E.S., L.K., K.B.) and Dermatology (A.-K.M., L.D.), the Institute for Hygiene and Applied Immunology (R.P., J.B.H.) and the Institute of Immunology (W.F.P.), Center for Pathophysiology, Infectiology, and Immunology, and the Institute of Artificial Intelligence, Center for Medical Data Science (C.B.), Medical University of Vienna, the St. Anna Children's Hospital (E.S., L.K., K.B.), the Department of Structural and Computational Biology, Max Perutz Labs, and the Faculty of Mathematics, University of Vienna (J.M.), Vienna, and the Karl Landsteiner University of Health Sciences, Krems (W.F.P.) - all in Austria; Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM and Paul Sabatier University (Unité Mixte de Recherche 1297) (J.V.), Toulouse, and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, the University of Paris, and the Laboratory of Excellence for Red Cells, Laboratory of Excellence GR-Ex, Paris (L.D.C.) - all in France; the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.); the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.); the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for Infectious Diseases, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (C.I.M., A.H.), the Department of Clinical Genetics, Maastricht University Medical Center, and GROW School for Oncology and Reproduction, Maastricht University, Maastricht (H.G.B.), and the Department of Pediatrics, Slingeland Hospital, Doetinchem (J.E.N.-F.) - all in the Netherlands; the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany; the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), Barcelona, and the Pediatric Infectious Diseases, Rheumatology, and Immunology Unit (P.S.M., M.C.-L., O.N.) and the Department of Pathology (R.Á.P., R.C.-P.), Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Seville - all in Spain; the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.); the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.); and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.).
Publikováno v:
The New England journal of medicine [N Engl J Med] 2023 Aug 10; Vol. 389 (6), pp. 527-539. Date of Electronic Publication: 2023 Jun 21.
Autor:
Wang L; Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China.; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Aschenbrenner D; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Department of Pediatrics, John Radcliffe Hospital, Oxford, UK., Zeng Z; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Cao X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Mayr D; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Mehta M; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Capitani M; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Department of Pediatrics, John Radcliffe Hospital, Oxford, UK., Warner N; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Pan J; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Wang L; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University, Shanghai, China.; School of Life Sciences, East China Normal University, Shanghai, China., Li Q; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Zuo T; Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China.; Institute of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China., Cohen-Kedar S; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel., Lu J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University, Shanghai, China.; School of Life Sciences, East China Normal University, Shanghai, China., Ardy RC; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Mulder DJ; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Dissanayake D; Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada., Peng K; Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China., Huang Z; Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China., Li X; Department of Gastroenterology, Zhengzhou Children's Hospital, Zhengzhou, China., Wang Y; Department of Gastroenterology, Zhengzhou Children's Hospital, Zhengzhou, China., Wang X; Neonate Department, Sanmenxia Central Hospital, Sanmenxia, China., Li S; Department of Pediatrics, Lushi County Renmin Hospital, Sanmenxia, China., Bullers S; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Department of Pediatrics, John Radcliffe Hospital, Oxford, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Gammage AN; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Warnatz K; Department of Rheumatology and Clinical Immunology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany., Schiefer AI; Department of Clinical Pathology, Medical University Vienna, Vienna, Austria., Krivan G; National Institute of Hematology and Infectious Diseases, Department for Pediatric Hematology and Hemopoietic Stem Cell Transplantation, Central Hospital of Southern Pest, Budapest, Hungary., Goda V; National Institute of Hematology and Infectious Diseases, Department for Pediatric Hematology and Hemopoietic Stem Cell Transplantation, Central Hospital of Southern Pest, Budapest, Hungary., Kahr WHA; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.; Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Lemaire M; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada., Lu CY; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Siddiqui I; Division of Pathology, Department of Pediatric Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada., Surette MG; Department of Medicine, Farncombe Family Digestion Health Institute, McMaster University, Hamilton, Ontario, Canada., Kotlarz D; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University Munich, Munich, Germany., Engelhardt KR; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Griffin HR; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Rottapel R; Princess Margaret Cancer Centre, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.; Division of Rheumatology, St. Michael's Hospital, Toronto, Ontario, Canada., Decaluwe H; Division of Immunology and Rheumatology, Department of Pediatrics, Sainte-Justine University Hospital, Montreal, Quebec, Canada.; Cytokine and Adaptive Immunity Laboratory, Sainte-Justine University Hospital Research Center, Université de Montréal, Montreal, Quebec, Canada., Laxer RM; Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Proietti M; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany., Hambleton S; Faculty of Medical Sciences, 100KGP England, Newcastle University, Newcastle upon Tyne, UK., Elcombe S; Department of Immunology, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Guo CH; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Grimbacher B; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.; DZIF - German Center for Infection Research, Satellite Center Freiburg, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Albert-Ludwigs-University of Freiburg, Freiburg, Germany., Dotan I; Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Ng SC; Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China.; Institute of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China., Freeman SA; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada., Snapper SB; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Klein C; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University Munich, Munich, Germany., Boztug K; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Huang Y; Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China. yhuang815@163.com., Li D; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. dlli@bio.ecnu.edu.cn., Uhlig HH; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Department of Pediatrics, John Radcliffe Hospital, Oxford, UK., Muise AM; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. aleixo.muise@utoronto.ca.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. aleixo.muise@utoronto.ca.; Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. aleixo.muise@utoronto.ca.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. aleixo.muise@utoronto.ca.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. aleixo.muise@utoronto.ca.
Publikováno v:
Nature genetics [Nat Genet] 2022 Feb; Vol. 54 (2), pp. 213.
Autor:
Ouahed J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA., Kelsen JR; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Spessott WA; Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Kooshesh K; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Sanmillan ML; Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Dawany N; Department of Biomedical Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Sullivan KE; Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Hamilton KE; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Slowik V; Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Nejentsev S; Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Neves JF; Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Primary Immunodeficiencies Unit; Hospital Dona Estefânia-CHLC, EPE, Lisbon, 1169, Portugal., Flores H; CEDOC, Chronic Diseases Research Center, NOVA Medical School, Lisbon, 1150, Portugal., Chung WK; Gastroenterology Unit, Hospital Dona Estefânia-CHLC, EPE, Lisbon, 1169, Portugal., Wilson A; Gastroenterology Unit, Hospital Dona Estefânia-CHLC, EPE, Lisbon, 1169, Portugal., Anyane-Yeboa K; Gastroenterology Unit, Hospital Dona Estefânia-CHLC, EPE, Lisbon, 1169, Portugal., Wou K; Gastroenterology Unit, Hospital Dona Estefânia-CHLC, EPE, Lisbon, 1169, Portugal., Jain P; Department of Pediatrics, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Field M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA., Tollefson S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA., Dent MH; Department of Genetics, Yale University, New Haven, CT, 06510, USA., Li D; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Naito T; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., McGovern DPB; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Kwong AC; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Taliaferro F; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Ordovas-Montanes J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Program in Immunology, Harvard Medical School, Boston, MA, 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA, 02138, USA., Horwitz BH; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Division of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA., Kotlarz D; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU Munich, Munich, 80337, Germany., Klein C; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU Munich, Munich, 80337, Germany., Evans J; Department of Pediatrics, Nemours Children's Specialty Care, Jacksonville, FL 32207, USA., Dorsey J; Department of Pediatrics, Nemours Children's Specialty Care, Jacksonville, FL 32207, USA., Warner N; SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Elkadri A; SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Muise AM; SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Goldsmith J; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Thompson B; Primary Immunodeficiency Group, III Theme, Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK., Engelhardt KR; Primary Immunodeficiency Group, III Theme, Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK., Cant AJ; Primary Immunodeficiency Group, III Theme, Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.; Children's Immunology Service, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, NE1 4LP, UK., Hambleton S; Primary Immunodeficiency Group, III Theme, Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.; Children's Immunology Service, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, NE1 4LP, UK., Barclay A; Department of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, G51 4TF, UK., Toth-Petroczy A; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Vuzman D; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Carmichael N; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Bodea C; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Cassa CA; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Devoto M; Division of Human Genetics, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Translational and Precision Medicine, University Sapienza, Rome 00185, Italy.; CNR-IRGB, Cagliari 09042, Italy., Maas RL; Brigham Genomic Medicine Program, Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Behrens EM; Division of Rheumatology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Giraudo CG; Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Snapper SB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.; Division of Gastroenterology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Publikováno v:
Journal of Crohn's & colitis [J Crohns Colitis] 2021 Nov 08; Vol. 15 (11), pp. 1908-1919.