HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation

Autor: Tsamadou, Chrysanthi, Engelhardt, Daphne, Platzbecker, Uwe, Sala, Elisa, Valerius, Thomas, Wagner-Drouet, Eva, Wulf, Gerald, Kröger, Nicolaus, Murawski, Niels, Einsele, Hermann, Schaefer-Eckart, Kerstin, Freitag, Sebastian, Caspar, Jochen, Kaufmann, Martin, Dürholt, Mareike, Hertenstein, Bernd, Klein, Stefan, Ringhoffer, Mark, Frank, Sandra, Neuchel, Christine, Schrezenmeier, Hubert, Mytilineos, Joannis, Fuerst, Daniel

The HLA-DRB3/4/5 loci are closely linked to the HLA-DRB1 gene. Mismatches in these loci occur with a frequency of about 8%–12% in otherwise 10/10 HLA-matched transplant pairs. There is preliminary evidence that these disparities may associate with

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The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination.

Autor: Mühlenbruch, Lena, Abou-Kors, Tsima, Dubbelaar, Marissa L., Bichmann, Leon, Kohlbacher, Oliver, Bens, Martin, Thomas, Jaya, Ezić, Jasmin, Kraus, Johann M., Kestler, Hans A., von Witzleben, Adrian, Mytilineos, Joannis, Fürst, Daniel, Engelhardt, Daphne, Doescher, Johannes, Greve, Jens, Schuler, Patrick J., Theodoraki, Marie-Nicole, Brunner, Cornelia, Hoffmann, Thomas K.

Publikováno v: British Journal of Cancer; May2023, Vol. 128 Issue 9, p1777-1787, 11p

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HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation.

Autor: Tsamadou C; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, and University Hospital Ulm, Ulm, Germany.; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany., Engelhardt D; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany.; Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, Ulm, Germany., Platzbecker U; Department of Hematology/Oncology, University of Leipzig, Leipzig, Germany., Sala E; Department of Internal Medicine III, University of Ulm, Ulm, Germany., Valerius T; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian Albrechts University, Kiel, Germany., Wagner-Drouet E; Department of Medicine III, Johannes Gutenberg-University, Mainz, Germany., Wulf G; Department of Hematology/Oncology, Georg-August-University, Göttingen, Germany., Kröger N; Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany., Murawski N; Department of Internal Medicine I, Universitätsklinikum des Saarlandes, Homburg, Germany., Einsele H; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany., Schaefer-Eckart K; Medical Clinic 5: Hematology, Oncology, Nuremberg Hospital, Nuremberg, Germany., Freitag S; Department of Medicine III, Hematology/Oncology/Palliative Care, Rostock University Medical Center, Rostock, Germany., Casper J; Department of Oncology and Hematology, Klinikum Oldenburg, University Clinic, Oldenburg, Germany., Kaufmann M; 2nd Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital, Stuttgart, Germany., Dürholt M; Hematology/Oncology, Evangelic Clinic Essen-Werden, Essen-Werden, Germany., Hertenstein B; Hematology/Oncology, Klinikum Bremen-Mitte, Bremen, Germany., Klein S; Universitätsmedizin Mannheim, Med. Klinik III, Mannheim, Germany., Ringhoffer M; Medizinische Klinik III, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany., Frank S; DRST -Deutsches Register für Stammzelltransplantationen, German Registry for Stem Cell Transplantation, Ulm, Germany., Neuchel C; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, and University Hospital Ulm, Ulm, Germany.; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany., Schrezenmeier H; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, and University Hospital Ulm, Ulm, Germany.; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany., Mytilineos J; DRST -Deutsches Register für Stammzelltransplantationen, German Registry for Stem Cell Transplantation, Ulm, Germany.; ZKRD-Zentrales Knochenmarkspender-Register für Deutschland, German National Bone Marrow Donor Registry, Ulm, Germany., Fuerst D; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, and University Hospital Ulm, Ulm, Germany.; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Dec 14; Vol. 12, pp. 771449. Date of Electronic Publication: 2021 Dec 14 (Print Publication: 2021).