Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Autor: Mendes de Almeida V; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Engel DF; Department of Clinical Analysis, School of Pharmacy, Universidade Federal de Ouro Preto - UFOP, Ouro Preto, Brazil., Ricci MF; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Cruz CS; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Lopes ÍS; Laboratory of Virus Bioinformatics - Department of Biological Science, Center of Biotechnology and Genetics, Universidade Estadual de Santa Cruz - UESC, Ilhéus, Brazil., Alves DA; Laboratory of RNA Interference and Antiviral Immunity - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., d' Auriol M; Laboratory of Toxicology - Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Magalhães J; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Machado EC; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Rocha VM; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Carvalho TG; Laboratory of Neurobiochemistry - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Lacerda LSB; Center for Research and Development of Drugs - Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Pimenta JC; Center for Research and Development of Drugs - Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Aganetti M; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Zuccoli GS; Laboratory of Neuroproteomics - Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade do Estado de Campinas - UNICAMP, Campinas, Brazil., Smith BJ; Laboratory of Neuroproteomics - Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade do Estado de Campinas - UNICAMP, Campinas, Brazil., Carregari VC; Laboratory of Neuroproteomics - Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade do Estado de Campinas - UNICAMP, Campinas, Brazil., da Silva Rosa E; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Galvão I; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Dantas Cassali G; Laboratory of Comparative Pathology - Department of Pathology, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Garcia CC; Laboratory of Respiratory Viruses and Measles, Instituto Oswaldo Cruz - Fiocruz, Rio de Janeiro, Brazil., Teixeira MM; Center for Research and Development of Drugs - Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., André LC; Laboratory of Toxicology - Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Ribeiro FM; Laboratory of Neurobiochemistry - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Martins FS; Laboratory of Biotherapeutic Agents - Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Saia RS; Laboratory of Intestinal Physiology - Department of Physiology, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil., Costa VV; Center for Research and Development of Drugs - Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil., Martins-de-Souza D; Laboratory of Neuroproteomics - Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade do Estado de Campinas - UNICAMP, Campinas, Brazil.; D'Or Institute for Research and Education, São Paulo, Brazil.; Experimental Medicine Research Cluster, Universidade do Estado de Campinas - UNICAMP, Campinas, Brazil.; National Institute of Biomarkers in Neuropsychiatry, National Council for Scientific and Technological Development, São Paulo, Brazil., Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, Australia., Marques JT; Laboratory of RNA Interference and Antiviral Immunity - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil.; CNRS UPR9022, University of Strasbourg, Strasbourg, France., Aguiar ERGR; Laboratory of Virus Bioinformatics - Department of Biological Science, Center of Biotechnology and Genetics, Universidade Estadual de Santa Cruz - UESC, Ilhéus, Brazil., Vieira AT; Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil.

Publikováno v: Gut microbes [Gut Microbes] 2023 Dec; Vol. 15 (2), pp. 2249146.

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2.

Autor: Zanesco AM; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., Mendes NF; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., Engel DF; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil., Gaspar RS; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., Sidarta-Oliveira D; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., Donato J Jr; Department of Physiology and Biophysics, University of São Paulo, São Paulo 05508-900, Brazil., Velloso LA; School of Medicical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil.

Publikováno v: Cells [Cells] 2022 Jun 22; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 22.

Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout (LDLr ^-/- ) mice.

Autor: De Paula GC; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., de Oliveira J; Laboratory of Experimental Neurology, Extremo Sul Catarinense University, Criciúma, Brazil., Engel DF; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., Lopes SC; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil., Moreira ELG; Department of Physiological Science, Federal University of Santa Catarina, Florianópolis, Brazil., Figueiredo CP; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Prediger RD; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil., Fabro de Bem A; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil.; Department of Physiological Science, University of Brasilia, Brasilia, Brazil.

Publikováno v: Nutritional neuroscience [Nutr Neurosci] 2021 Dec; Vol. 24 (12), pp. 978-988. Date of Electronic Publication: 2020 Jan 07.

Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood-Brain Barrier Permeability and Neuroinflammation as Triggering Events.

Autor: de Paula GC; Postgraduate Program in Biochemistry, Department of Biochemistry, Federal University of Santa Catarina, Florianopolis, Brazil.; Multicenter Graduate Program in Physiological Sciences, Federal University of Santa Catarina, Florianopolis, Brazil., Brunetta HS; Multicenter Graduate Program in Physiological Sciences, Federal University of Santa Catarina, Florianopolis, Brazil., Engel DF; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Gaspar JM; Postgraduate Program in Biochemistry, Department of Biochemistry, Federal University of Santa Catarina, Florianopolis, Brazil., Velloso LA; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Engblom D; Department of Clinical and Experimental Medicine, Faculty of Medicine and Health, Linköping University, Linköping, Sweden., de Oliveira J; Postgraduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., de Bem AF; Department of Clinical and Experimental Medicine, Faculty of Medicine and Health, Linköping University, Linköping, Sweden.; Department of Physiological Science, University of Brasília, Brasília, Brazil.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2021 Nov 04; Vol. 15, pp. 734158. Date of Electronic Publication: 2021 Nov 04 (Print Publication: 2021).

Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis.

Autor: Bobbo VC; Nursing School, University of Campinas, Campinas, Brazil.; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Engel DF; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Jara CP; Nursing School, University of Campinas, Campinas, Brazil.; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Mendes NF; Nursing School, University of Campinas, Campinas, Brazil.; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Haddad-Tovolli R; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Prado TP; Nursing School, University of Campinas, Campinas, Brazil.; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Sidarta-Oliveira D; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Morari J; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Velloso LA; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil., Araujo EP; Nursing School, University of Campinas, Campinas, Brazil. earaujo@unicamp.br.; Laboratory of Cell Signaling, University of Campinas, Rua Cinco de Junho, 350, Cidade Universitária, Campinas, SP, 13083-877, Brazil. earaujo@unicamp.br.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2021 Aug 31; Vol. 18 (1), pp. 192. Date of Electronic Publication: 2021 Aug 31.