Promoter Activation In Delta Hfq Mutants As An Efficient Tool For Specialized Metabolite Production Enabling Direct Bioactivity Testing

Autor: Bode, Edna, Heinrich, Antje K., Hirschmann, Merle, Abebew, Desalegne, Shi, Yan-Ni, Tien Duy Vo, Wesche, Frank, Shi, Yi-Ming, Gruen, Peter, Simonyi, Svenja, Keller, Nadine, Engel, Yvonne, Wenski, Sebastian, Bennet, Reuel, Beyer, Sophie, Bischoff, Iris, Buaya, Anthony, Brandt, Sophie, Cakmak, Ibrahim, Cimen, Harun

Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene-sequencesimilarity-based bioinf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r39c86a4b39b::248067e1b649971812dd01868f2889e8
https://aperta.ulakbim.gov.tr/record/67757

Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.

Autor: Bode, Edna, Heinrich, Antje K., Hirschmann, Merle, Abebew, Desalegne, Shi, Yan‐Ni, Vo, Tien Duy, Wesche, Frank, Shi, Yi‐Ming, Grün, Peter, Simonyi, Svenja, Keller, Nadine, Engel, Yvonne, Wenski, Sebastian, Bennet, Reuel, Beyer, Sophie, Bischoff, Iris, Buaya, Anthony, Brandt, Sophie, Cakmak, Ibrahim, Çimen, Harun

Publikováno v: Angewandte Chemie International Edition; 12/19/2019, Vol. 58 Issue 52, p18957-18963, 7p

Back Cover: Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. Int. Ed. 52/2019).

Autor: Bode, Edna, Heinrich, Antje K., Hirschmann, Merle, Abebew, Desalegne, Shi, Yan‐Ni, Vo, Tien Duy, Wesche, Frank, Shi, Yi‐Ming, Grün, Peter, Simonyi, Svenja, Keller, Nadine, Engel, Yvonne, Wenski, Sebastian, Bennet, Reuel, Beyer, Sophie, Bischoff, Iris, Buaya, Anthony, Brandt, Sophie, Cakmak, Ibrahim, Çimen, Harun

Publikováno v: Angewandte Chemie International Edition; 12/19/2019, Vol. 58 Issue 52, p19114-19114, 1p

Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.

Autor: Bode E; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Heinrich AK; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Hirschmann M; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Abebew D; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Shi YN; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Vo TD; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Wesche F; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Shi YM; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Grün P; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany.; LOEWE-TBG, 60325, Frankfurt, Germany., Simonyi S; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany.; LOEWE-TBG, 60325, Frankfurt, Germany., Keller N; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Engel Y; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Wenski S; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany., Bennet R; Senckenberg BiK-F, 60325, Frankfurt, Germany., Beyer S; Cell Biology and Neuroscience, Department of Developmental Biology of Vertebrates, 60438, Frankfurt, Germany., Bischoff I; Pharmaceutical Biology, Faculty of Biochemistry, Chemistry and Pharmacy, University of Frankfurt, 60438, Frankfurt, Germany., Buaya A; Senckenberg BiK-F, 60325, Frankfurt, Germany., Brandt S; Mol. Phytopathol., Univ. Hamburg, 22609, Hamburg, Germany., Cakmak I; Aydin Adnan Menderes University, Department of Plant Protection, 09100, Aydin, Turkey., Çimen H; Aydin Adnan Menderes University, Department of Biology, 09100, Aydin, Turkey., Eckstein S; Universität Mainz, Molekulare Physiologie, Mikrobiologie und Weinforschung, 55128, Mainz, Germany., Frank D; University Hospital Frankfurt, Medical Microbiology and Infection Control, 60596, Frankfurt, Germany., Fürst R; LOEWE-TBG, 60325, Frankfurt, Germany.; Pharmaceutical Biology, Faculty of Biochemistry, Chemistry and Pharmacy, University of Frankfurt, 60438, Frankfurt, Germany., Gand M; Mol. Phytopathol., Univ. Hamburg, 22609, Hamburg, Germany.; Current address: Food Chemistry and Food Biotechnology, University of Giessen, 35392, Giessen, Germany., Geisslinger G; LOEWE-TBG, 60325, Frankfurt, Germany.; Fraunhofer Inst. for Mol. Biol. and Appl. Ecology, Branch for Translat. Med. and Pharmacology, 60596, Frankfurt, Germany.; Univ. Hospital, Clin. Pharmacol., 60590, Frankfurt, Germany., Hazir S; Aydin Adnan Menderes University, Department of Biology, 09100, Aydin, Turkey., Henke M; LOEWE-TBG, 60325, Frankfurt, Germany.; Fraunhofer Inst. for Mol. Biol. and Appl. Ecology, Branch for Translat. Med. and Pharmacology, 60596, Frankfurt, Germany., Heermann R; Universität Mainz, Molekulare Physiologie, Mikrobiologie und Weinforschung, 55128, Mainz, Germany., Lecaudey V; Cell Biology and Neuroscience, Department of Developmental Biology of Vertebrates, 60438, Frankfurt, Germany., Schäfer W; Mol. Phytopathol., Univ. Hamburg, 22609, Hamburg, Germany., Schiffmann S; LOEWE-TBG, 60325, Frankfurt, Germany.; Fraunhofer Inst. for Mol. Biol. and Appl. Ecology, Branch for Translat. Med. and Pharmacology, 60596, Frankfurt, Germany., Schüffler A; IBWF gGmbH, Biotechnology and Drug Research, 67663, Kaiserslautern, Germany., Schwenk R; LOEWE-TBG, 60325, Frankfurt, Germany.; Pharmaceutical Biology, Faculty of Biochemistry, Chemistry and Pharmacy, University of Frankfurt, 60438, Frankfurt, Germany., Skaljac M; Fraunhofer Institute for Molecular Biology and Applied Ecology, Branch for Bioresources, 35394, Giessen, Germany., Thines E; IBWF gGmbH, Biotechnology and Drug Research, 67663, Kaiserslautern, Germany.; Microbiology and Wine Research at the Institute of Molecular Physiology (IMP), University of Mainz, 55128, Mainz, Germany., Thines M; LOEWE-TBG, 60325, Frankfurt, Germany.; Senckenberg BiK-F, 60325, Frankfurt, Germany.; Univ. Frankfurt, Ecology, Evolution and Diversity, 60438, Frankfurt, Germany., Ulshöfer T; Fraunhofer Inst. for Mol. Biol. and Appl. Ecology, Branch for Translat. Med. and Pharmacology, 60596, Frankfurt, Germany., Vilcinskas A; LOEWE-TBG, 60325, Frankfurt, Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology, Branch for Bioresources, 35394, Giessen, Germany.; Univ. Giessen, Insect Biotechnology, 35392, Giessen, Germany., Wichelhaus TA; University Hospital Frankfurt, Medical Microbiology and Infection Control, 60596, Frankfurt, Germany., Bode HB; Mol. Biotechnol., Univ. Frankfurt, 60438, Frankfurt, Germany.; LOEWE-TBG, 60325, Frankfurt, Germany.; BMLS, Univ. Frankfurt, 60438, Frankfurt, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Dec 19; Vol. 58 (52), pp. 18957-18963. Date of Electronic Publication: 2019 Dec 12.