Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Eng-Shang Huang"'
Autor:
David Y. Huang, Shu-Mei Huong, Haobin Cai, Chang-Yong Cha, Eung Soo Hwang, Eng-Shang Huang, Zhigang Zhang
Publikováno v:
Journal of Virology. 83:12388-12398
Infection of host cells with human cytomegalovirus (HCMV) induces cell cycle dysregulation. Two HCMV immediate-early (IE) proteins, IE1-72 and IE2-86, are promiscuous transactivators that have been implicated in the dysregulatory events. Cellular p53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519de4465237b4d911f7895ff45d1964
https://doi.org/10.1128/jvi.00304-09
https://doi.org/10.1128/jvi.00304-09
Publikováno v:
Antiviral Research
We report antiviral activity against human cytomegalovirus for certain dietary flavonoids and their likely biochemical mechanisms of action. Nine out of ten evaluated flavonoids blocked HCMV replication at concentrations that were significantly lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24d2233449b635a1f77b77e0d36d599
http://europepmc.org/articles/PMC7114262
http://europepmc.org/articles/PMC7114262
Publikováno v:
Nature Medicine. 11:515-521
HCMV is a widespread opportunistic pathogen that causes birth defects in newborns and severe disease in immunocompromised individuals. The broad tropism of HCMV infection suggests that it utilizes multiple receptors. We recently demonstrated that EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dd8e7cba0dfb7fe6911803e947da2b
https://doi.org/10.1038/nm1236
https://doi.org/10.1038/nm1236
Publikováno v:
Antiviral Research. 65:1-12
FK778 (Fujisawa Healthcare Inc.) is an immunosuppressant structurally similar to A771726, the active metabolite of leflunomide (Aventis Pharmaceuticals), but with a clinically relevant shorter serum half-life. Leflunomide, a tolerated and efficacious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00487287ebd5990f07dfe48718992166
https://doi.org/10.1016/j.antiviral.2004.03.007
https://doi.org/10.1016/j.antiviral.2004.03.007
Autor:
Lei Fu, Yashang Lee, Ju-Liang Zhu, Eng-Shang Huang, Ginger E. Dutschman, Hosup Yeo, Elizabeth A. Gullen, Ying Li, Yung-Chi Cheng, Raymond T. Chung, David J. Austin
Publikováno v:
Journal of Medicinal Chemistry. 48:534-546
A series of natural product analogues based on helioxanthin (2), with particular attention to modification of the lactone ring and methylenedioxy group, were synthesized and evaluated for their antiviral activities. Among them, lactam derivative 18 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0fe624b9bed6da5084ebf884ed5067
https://doi.org/10.1021/jm034265a
https://doi.org/10.1021/jm034265a
Publikováno v:
Microbes and Infection. 6:1084-1093
Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68cdce2c6c4e782565901c21818471
https://doi.org/10.1016/j.micinf.2004.05.026
https://doi.org/10.1016/j.micinf.2004.05.026
Publikováno v:
Antiviral Research. 63:85-95
Resveratrol is a polyphenolic natural product that is present in red wine and peanuts and has inhibitory activity against inflammation, heart disease, and cancer. Here we describe its inhibition of human cytomegalovirus replication (IC50 = 1-2 microM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6f48a94ba818db8525152da2b59d70
https://doi.org/10.1016/j.antiviral.2004.03.002
https://doi.org/10.1016/j.antiviral.2004.03.002
Autor:
Xin Wang, Eng-Shang Huang, Shu-Mei Huong, Manfred Marschall, Thomas Stamminger, Thomas Efferth, Armin Olbrich, Ilona Hauber, Martina Kronschnabl
Publikováno v:
Journal of Molecular Medicine. 80:233-242
Antiviral therapy of primary and recurrent infections with human cytomegalovirus is reserved for severe manifestations and faces several limitations. Presently candidates for novel drugs with lower adverse side effects and a minimized frequency of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66752bbb825cb47b38b9dab423f320cb
https://doi.org/10.1007/s00109-001-0300-8
https://doi.org/10.1007/s00109-001-0300-8
Publikováno v:
Journal of Virology. 75:6022-6032
Infection of quiescent fibroblasts with human cytomegalovirus (HCMV) was found to cause a rapid activation of cellular phosphatidylinositol 3-kinase (PI3-K). Maximum PI3-K activation occurred from 15 to 30 min postinfection. This activation was trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158e5caf7662bb5358de4096ed344d5e
https://doi.org/10.1128/jvi.75.13.6022-6032.2001
https://doi.org/10.1128/jvi.75.13.6022-6032.2001